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ProteomicsDiscovery and development of a potent LIMK2 isoform-specific degrader
The LIM kinases (LIMK1/2) are key mediators in the multi-step signaling cascades that regulate actin cytoskeleton dynamics via cofilin phosphorylation. Dysregulation of these pathways and overexpression of LIMKs are implicated in disease development, including cancer, Fragile X syndrome, and glaucom...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD067130 | Pride
Limk Protac 
ProteomicsBAG3 regulates cilia homeostasis of glioblastoma via its WW domain
The multidomain protein BAG3 exerts pleiotropic oncogenic functions in many tumor entities including glioblastoma (GBM). Here we compared BAG3 protein-protein interactions in either adherently cultured or stem-like cultured U251 GBM cells. In line with BAG3´s putative role in stemness, identified in...
ORGANISM(S): Homo sapiens (Human) 
2024-04-09 | PXD050279 | Pride
Cilia homeostasis Stemness Yap1 Ww domain Glioblastoma Bag3 Yap1 signaling Primary cilia 
ProteomicsA general workflow for E3 ligase ligand validation for PROTAC development
PROteolysis TArgeting Chimeras (PROTACs) have gained considerable attention as a new modality in drug discovery. However, the development of PROTACs has been mainly focused on CRBN (Cereblon) and VHL (van Hippel-Lindau Ligase) ligands. The considerable size of the human E3 ligase family, newly devel...
ORGANISM(S): Homo sapiens (Human) 
2025-04-04 | PXD057431 | Pride
Protac Vhl Promiscious kinase inhibitor 
ProteomicsREEP1 Accumulation Disrupts ER Integrity and Drives Spinal Motoneuron Degeneration in Distal Hereditary Motor Neuropathy
REEP1 contributes to the shaping of the endoplasmic reticulum (ER) through conserved transmembrane hairpins (THs) and a long C-terminal amphipathic helix. Its loss-of-function causes spastic paraplegia due to degeneration of axons of cortical motoneurons projecting to spinal motoneurons. Patients wi...
ORGANISM(S): Homo sapiens (Human) 
2026-01-19 | PXD067700 | Pride
Reep1 Dhmn Membrane shaping Endoplasmic reticulum Ubiquitination Hsp 
ProteomicsMulti-scale classification decodes the complexity of the human E3 ligome
E3 ubiquitin ligases are key regulators of protein homeostasis, targeting specific proteins for degradation via the ubiquitin-proteasome system (UPS). They provide crucial substrate specificity, making them promising candidates for the design of novel therapeutics. This work presents a comprehensive...
ORGANISM(S): Homo sapiens (Human) 
2025-11-18 | PXD067015 | Pride
E3 ligase 
ProteomicsDiscovery and development of a potent LIMK2 isoform-specific degrader
The LIM kinases (LIMK1/2) are key mediators in the multi-step signaling cascades that regulate actin cytoskeleton dynamics via cofilin phosphorylation. Dysregulation of these pathways and overexpression of LIMKs are implicated in disease development, including cancer, Fragile X syndrome, and glaucom...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD067224 | Pride
Limk Protac 
ProteomicsDiscovery and development of a potent LIMK2 isoform-specific degrader
The LIM kinases (LIMK1/2) are key mediators in the multi-step signaling cascades that regulate actin cytoskeleton dynamics via cofilin phosphorylation. Dysregulation of these pathways and overexpression of LIMKs are implicated in disease development, including cancer, Fragile X syndrome, and glaucom...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD067272 | Pride
Limk Protac 
ProteomicsDNA-Protein Crosslinks Promote cGAS-STING-driven Premature Aging and Embryonic Lethality
DNA-protein crosslinks (DPCs) are severe DNA lesions that disrupt replication, transcription, and genome stability. However, their role in development and aging remains poorly understood. Here, we show that impaired SPRTN function, a metalloprotease essential for DPC repair during replication and mi...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-30 | PXD067624 | Pride
Emrbyo Sprtn Dpc 
ProteomicsDNA-Protein Crosslinks Promote cGAS-STING-driven Premature Aging and Embryonic Lethality
DNA-protein crosslinks (DPCs) are severe DNA lesions that disrupt replication, transcription, and genome stability. However, their role in development and aging remains poorly understood. Here, we show that impaired SPRTN function, a metalloprotease essential for DPC repair during replication and mi...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-09-30 | PXD051378 | Pride
Innate immunity Pyroptosis. Cgas-sting Mitosis Interferon Dpcs Sprtn Embryonic lethality 
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