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ProteomicsSequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formation
The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds the cell surface protein ACE2 to mediate fusion of the viral membrane with target cells1-4. S comprises a large external domain, a transmembrane domain (TMD) and a short cytoplasmic tail5,6. To elucidate the ...
ORGANISM(S): Homo sapiens (Human) 
2021-07-30 | PXD022215 | Pride
Golgi Sars-cov-2 Copi S protein 
ProteomicsA cryo-EM structure of metazoan TRAPPIII, the multisubunit complex that activates the GTPase Rab1
The TRAPP complexes are nucleotide exchange factors that have essential roles in membrane traffic and autophagy. TRAPPII activates Rab11, and TRAPPIII activates Rab1, with the two complexes sharing a core of small subunits that affect nucleotide exchange, but being distinguished by specific large su...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-06-03 | PXD025064 | Pride
Exchange factor / rab1 / autophagy / membrane traffic / golgi 
ProteomicsIn vivo identification of GTPase interactors by mitochondrial relocalizationand proximity biotinylation
The ~160 small GTPases that comprise the Ras superfamily include many major regulators of growth, membrane traffic and the cytoskeleton, and a wide range of diseases are caused by mutations in particular members. They function as switchable landmarks with the active GTP-bound form recruiting to the ...
ORGANISM(S): Homo sapiens (Human) 
2019-07-17 | PXD013668 | Pride
Human Mitochondria gtpase Bira* Ras Lc-ms/ms Membranes Gefs 
ProteomicsIdentification of p115 interacting proteins from HEK293T cells
The protein p115 is a key player in the delivery of vesicles from the endoplasmic reticulum to the early Golgi. The protein is a homodimer with a folded head domain and a coiled-coil tail that is anchored to Golgi membranes. p115 has been shown to capture vesicles and to bind to SNARE proteins to p...
ORGANISM(S): Homo sapiens (Human) 
2026-06-02 | PXD075617 | Pride
Human Lc-msms P115 Uso1 Hek293t Sec16a 
ProteomicsSpatial proteomics defines the content of trafficking vesicles captured by golgin tethers
Intracellular traffic between compartments of the secretory and endocytic pathways is mediated by vesicle-based carriers. The proteomes of carriers destined for many organelles are ill-defined because the vesicular intermediates are transient, low-abundance and difficult to purify. Here, we combine ...
ORGANISM(S): Homo sapiens (Human) 
2020-12-01 | PXD018110 | Pride
Lopit-dc Organell protein relocalization Golgin Hela 
UnknownSequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formation.
Not available
S-EPMC8429659 | biostudies-literature
UnknownMembrane trafficking. The specificity of vesicle traffic to the Golgi is encoded in the golgin coiled-coil proteins.
Not available
S-EPMC4254398 | biostudies-literature
ProteomicsA Rab1 interactome illuminates its dual role in autophagy and membrane trafficking
The small GTPase Rab1 is found in all eukaryotes and acts in both ER-to-Golgi transport and autophagy. Several Rab1 effectors and regulators have been identified, but the mechanism by which Rab1 orchestrates these distinct processes remains incompletely understood. We apply MitoID, a proximity bioti...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-05 | PXD070863 | Pride
Crosslinking Sda 
UnknownThe golgin coiled-coil proteins capture different types of transport carriers via distinct N-terminal motifs.
Not available
S-EPMC5267433 | biostudies-literature
UnknownThe two TRAPP complexes of metazoans have distinct roles and act on different Rab GTPases.
Not available
S-EPMC5800803 | biostudies-literature
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