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ProteomicsBistability in the Rac1, PAK and RhoA signalling network is a feature of cell motility.
Dynamic interactions between RhoA and Rac1, members of the Rho small GTPase family, play a vital role in the control of cell migration. Using predictive mathematical modelling and experimental validation in MDA-MB-231 mesenchymal breast cancer cells, we show that Rac1 and RhoA interactions via the P...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080751 | MassIVE
TranscriptomicsENCODE Cold Spring Harbor Labs Long RNA-seq (hg19)
This data was generated by ENCODE. If you have questions about the data, contact the submitting laboratory directly (Carrie Davis mailto:davisc@cshl.edu (experimental), Alex Dobin mailto:dobin@cshl.edu (computational), Felix Schlesinger mailto:schlesin@cshl.edu (computational), Tom Gingeras mailto:g...
ORGANISM(S): Homo sapiens 
2011-07-13 | E-GEOD-30567 | biostudies-arrayexpress
ProteomicsAsparagine hydroxylation is likely to be a reversible post-translational modification
Amino acid hydroxylation is a common post-translational modification, which generally regulates protein interactions or adds a functional group that can be further modified. Such hydroxylation is currently considered irreversible, necessitating the degradation and re-synthesis of the entire protein ...
ORGANISM(S): Hordeum vulgare (Barley) 
2020-03-23 | PXD013116 | Pride
Lc-ms/ms Hydroxylation Hypoxia Ptm 
ProteomicsPHD3 and FIH substrates cluster in distinct signalling pathways
Amino acid hydroxylation is a common post-translational modification which regulates intra and inter-molecular protein-protein interactions. The modifications are regulated by a family of 2-oxoglutarate (2OG) dependent enzymes and although the biochemistry is well understood, until now only a few su...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080766 | MassIVE
ProteomicsBistability in the Rac1, PAK and RhoA signalling network is a feature of cell motility.
Dynamic interactions between RhoA and Rac1, members of the Rho small GTPase family, play a vital role in the control of cell migration. Using predictive mathematical modelling and experimental validation in MDA-MB-231 mesenchymal breast cancer cells, we show that Rac1 and RhoA interactions via the P...
ORGANISM(S): Homo sapiens (Human) 
2016-12-23 | PXD003213 | Pride
Mathematical modelling Rhoa Cell motility Rac1 Bistable switches Pak inhibition 
TranscriptomicsSingle cell RNA sequencing of stem cell-derived retinal ganglion cells
We used human embryonic stem cell-derived retinal ganglion cells (RGCs) to characterize the transcriptome of 1,174 cells at the single cell level. The human embryonic stem cell line BRN3B-mCherry A81-H7 was differentiated to RGCs using a guided differentiation approach. Cells were harvested at day 3...
ORGANISM(S): Homo sapiens 
2017-10-07 | E-MTAB-6108 | biostudies-arrayexpress
ProteomicsPHD3 and FIH substrates cluster in distinct signalling pathways
Amino acid hydroxylation is a common post-translational modification which regulates intra and inter-molecular protein-protein interactions. The modifications are regulated by a family of 2-oxoglutarate (2OG) dependent enzymes and although the biochemistry is well understood, until now only a few su...
ORGANISM(S): Homo sapiens (Human) 
2016-03-30 | PXD001085 | Pride
Mapk6 Dmog Ripk4 Erk3 Hypoxia Hydroxylases 
ProteomicsProteomic analysis of SYNCRIP deficient HSPCs
Alterations in SYNCRIP activity were found to alter gene transcription in leukemia cells. The effects of transcription alterations on expression of the corresponding proteins were investigated by LC/MSMS
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD019779 | Pride
Lc-msms aml murine syncrip transcription regulation 
ProteomicsHuman cytomegalovirus induces neuronal gene expression through IE1 for viral maturation
Viral invasion of the host cell causes some of the most dramatic changes in biology. Human cytomegalovirus (HCMV) extensively remodels host cells, altering nuclear shape and generating a cytoplasmic viral-induced assembly compartment (vIAC). How these striking morphology changes occur in the context...
ORGANISM(S): Homo sapiens (Human) Cytomegalovirus 
2026-02-09 | PXD061284 | Pride
Human cytomegalovirus (hcmv) Macroh2a1 Histone ptms Chromatin 
ModelsNguyen2013 - Dynamic model of HIF regulation in hypoxia (reduced model)
Its a mathematcial model explaining regulation of HIF via FIH and oxygen. Model is further validated by Experimental data and various hypothesis has been tested on the same.
2019-12-10 | MODEL1912100005 | BioModels
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