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TranscriptomicsGene Expression profiling of Myc-induced lymphomagenesis
The ability of oncogenes to provoke cancer is harnessed by regulators that control cell proliferation or induce apoptosis, and bypass of these checkpoints is a hallmark of malignancies. Myc oncoproteins are overexpressed in ~70% of all cancers and induce numerous transcription targets that regulate ...
ORGANISM(S): Mus musculus 
2011-10-31 | E-GEOD-32239 | biostudies-arrayexpress
ProteomicsProteoglycan profiling of human, rat and mouse insulin-secreting cells
Proteoglycans (PGs) are proteins with glycosaminoglycan (GAG) chains, such as chondroitin sulfate (CS) or heparan sulfate (HS), attached to serine residues. We have earlier shown that prohormones can carry CS, thus, constituting a novel class of PGs. The mapping of GAG modifications of proteins in e...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) Rattus norvegicus (Rat) 
2022-02-16 | PXD024230 | Pride
Glycosaminoglycan Insulinoma islet cells Chromogranin-a Insulin Proteoglycan 
TranscriptomicsSingle-cell RNA-seq of tumor-infiltrating lymphocytes in metastatic uveal melanoma
Metastatic uveal melanoma generally responds poorly to immunotherapy. The aim here was to sequence tumor-infiltrating lymphocytes from uveal melanoma metastases to study their phenotypes and T-cell receptor (TCR) clonotypes. We performed paired single-cell transcriptome and TCR sequencing using the ...
ORGANISM(S): Homo sapiens 
2020-03-16 | E-MTAB-8846 | biostudies-arrayexpress
ProteomicsGlycosaminoglycan Domain Mapping of cellular chondroitin/dermatan sulfates
Here we report a simple and versatile approach for domain mapping of complex mixtures of glycosaminoglycans (GAGs), GAGDoMa. The approach is based on orthogonal enzymatic depolymerization of the GAGs, generating internal oligosaccharide, non-reducing end, and linkage region GAG domains, nanoflow rev...
ORGANISM(S): Homo sapiens (Human) 
2020-02-18 | PXD014504 | Pride
Higher-energy collision dissociation Gags Glycosaminoglycans Hcd Orbitrap elite Glycomics Negative ionisation mode Ion-pairing reversed-phase chromatography Dermatan sulfate Chondroitin sulfate 
ProteomicsGlycoproteomic and phenotypic elucidation of B4GALNT2 expression variants in the SID histo-blood group system
The Sda histo-blood group antigen [GalNAcβ1-4(NeuAcα2-3)Galβ-R] is present in colon, kidney and body fluids among 96-98% of Europeans whilst 90% have Sda-positive erythrocytes. Sda is implicated in various infections and constitutes a potential biomarker for colon cancer. The 2-4% truly Sd(a‒) indiv...
ORGANISM(S): Homo sapiens (Human) 
2022-04-07 | PXD023943 | Pride
Glycosylation Flow cytometry Glycopeptide Glycobiology Glycoprotein Sid blood group system Carbohydrate biosynthesis Erythrocyte Gene expression Glycosyltransferase 
ProteomicsGlycoproteomics identify disease-associated N-glycans and reduced occupancy of glycosylation sites in PMM2-CDG
The routine diagnostic pathway for congenital disorders of glycosylation (CDG) relies on carbohydrate deficient transferrin, a test that incompletely captures defects in N linked glycosylation and may yield false negative results even in classical N glycosylation disorders such as PMM2 CDG. To explo...
ORGANISM(S): Homo sapiens (Human) 
2026-09-28 | PXD080194 | Pride
N‐linked glycosylation Carbohydrate metabolism Glycoproteomics Congenital disorders of glycosylation (cdg) Glycopeptide Glycomics Biomarker Inborn error of metabolism 
ProteomicsCharacterization of MdpS: An In-depth Analysis of a MUC5B-Degrading Protease from Streptococcus oralis
Oral biofilms, comprising hundreds of bacteria and other microorganisms on oral mucosal and dental surfaces, play a central role in oral health and disease dynamics. Streptococcus oralis, a key constituent of these biofilms, contribute significantly to their formation, serving as an early colonizer ...
ORGANISM(S): Homo sapiens (Human) 
2024-04-18 | PXD046810 | Pride
Serine protease O-glycosylation Mucin degradation Oral biofilm Muc5b Streptococcus oralis 
ProteomicsMapping the human chondroitin sulfate glycoproteome reveals an unexpected correlation between glycan sulfation and attachment site characteristics
Chondroitin sulfate proteoglycans (CSPGs), an important class of carbohydrate-modified proteins, are composed of chondroitin sulfate (CS) polysaccharide(s) attached to different core proteins. CS polysaccharides interact with a multitude of protein ligands to control key events in homeostasis and de...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD037990 | Pride
Glycosaminoglycans  proteoglycans  glycoproteomics  glycopeptides 
ProteomicsN-glycoproteomic analyses of human intestinal enteroids, varying in histo-blood group geno- and phenotypes, reveal a wide repertoire of fucosylated glycoproteins
Human noroviruses, globally the main cause of viral gastroenteritis, show strain specific affinity for histo-blood group antigens (HBGA) and can successfully be propagated ex vivo in human intestinal enteroids (HIEs). HIEs established from jejunal stem cells of individuals with different ABO, Lewis ...
ORGANISM(S): Homo sapiens (Human) 
2024-04-10 | PXD046494 | Pride
Higher-energy collision dissociation Intestinal epithelium : glycoproteomics Host-pathogen interaction Histo-blood group antigens Human intestinal enteroids Fucosyltransferase Human norovirus Lc-ms/ms 
ProteomicsGlycosylation of somatic extracts and secretome in the infective stage of the helminth Fasciola hepatica
Fasciola hepatica is a global helminth parasite of humans and their livestock. The invasive stage of the parasite, the newly excysted juvenile (NEJs), relies on glycosylated excretedsecreted (ES) products and surface/somatic molecules to interact with host cells and tissues and to evade the host's i...
ORGANISM(S): Fasciola hepatica (Liver fluke) 
2024-01-26 | PXD045488 | Pride
Glycoproteomics Orbitrap Parasites Glycosylation Lc-ms/ms 
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