Sort   by:  
 Page size 
ProteomicsTRPS1 shapes YAP/TEAD-dependent transcription in breast cancer cells
Yes-associated protein (YAP), the downstream transducer of the Hippo pathway is a key regulator of organ size, differentiation and tumourigenesis. Yet, the activity of YAP can also be modulated by Hippo-independent functions. To disclose these Hippo-independent regulators, we performed a genome-wide...
ORGANISM(S): Homo sapiens (Human) 
2018-08-09 | PXD009819 | Pride
Trps1 Taz Breast cancer Yap Hippo Tead 
ProteomicsThe GID Ubiquitin Ligase Complex is a Regulator of AMPK Activity and Organismal Lifespan
The AMP-activated protein kinase (AMPK) regulates cellular energy homeostasis by sensing the metabolic status of the cell. AMPK is regulated by phosphorylation and dephosphorylation as a result of changing AMP/ATP levels and by removal of inhibitory ubiquitin residues by USP10. In this context, we i...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD015170 | Pride
Ampk  autophagy  gid  longevity  mtor  primary cilium  ubiquitination 
ProteomicsCharacterization and quantification of proteins secreted by single human embryos prior to implantation
The use of in vitro fertilization (IVF) has revolutionized the treatment of infertility and is now responsible for 1-5% of all births in industrialized countries. During IVF, it is typical for patients to generate multiple embryos. However, only a small proportion of them possess the genetic and met...
ORGANISM(S): Homo sapiens (Human) 
2015-10-20 | PXD002566 | Pride
Secretion Blastocoel Ivf Human blastocyst 
ProteomicsMapping sites of carboxymethyllysine modification on proteins reveals consequences for proteostasis and cell proliferation
Posttranslational mechanisms play a key role in modifying the abundance and function of cellular proteins. Among these, modification by advanced glycation end products (AGEs) has been shown to accumulate during aging and age-associated diseases but specific protein targets and functional consequence...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-11-25 | PXD027526 | Pride
Heart Acetylation Mass spectrometry Tubulin Kidney Mice Endothelial cell Cell cycle Microtubules Advanced glycation end products Carboxymethyllysine Mitosis Liver Glyoxal Proteasome Aging Posttranslational modification 
ProteomicsMapping sites of carboxymethyllysine modification on proteins reveals consequences for proteostasis and cell proliferation
Posttranslational mechanisms play a key role in modifying the abundance and function of cellular proteins. Among these, modification by advanced glycation end products (AGEs) has been shown to accumulate during aging and age-associated diseases but specific protein targets and functional consequence...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-11-25 | PXD021985 | Pride
Heart Acetylation Mass spectrometry Tubulin Kidney Mice Endothelial cell Cell cycle Microtubules Advanced glycation end products Carboxymethyllysine Mitosis Liver Glyoxal Proteasome Aging Posttranslational modification 
ProteomicsMapping sites of carboxymethyllysine modification on proteins reveals consequences for proteostasis and cell proliferation
Posttranslational mechanisms play a key role in modifying the abundance and function of cellular proteins. Among these, modification by advanced glycation end products (AGEs) has been shown to accumulate during aging and age-associated diseases but specific protein targets and functional consequence...
ORGANISM(S): Homo sapiens (Human) 
2021-11-25 | PXD027468 | Pride
Heart Acetylation Mass spectrometry Tubulin Kidney Mice Endothelial cell Cell cycle Microtubules Advanced glycation end products Carboxymethyllysine Mitosis Liver Glyoxal Proteasome Aging Posttranslational modification 
ProteomicsNuclear pore component Nup155 is part of the p53 network in liver cancer
Cancer-relevant signalling pathways rely on bidirectional nucleocytoplasmic transport events through the nuclear pore complex (NPC). However, mechanisms by which individual NPC components (Nups) participate in the regulation of these pathways remain poorly understood. We discovered by integrating la...
ORGANISM(S): Homo sapiens (Human) 
2019-04-09 | PXD012373 | Pride
Cancer Liver Nuclear pore P53 
ProteomicsMapping sites of carboxymethyllysine modification on proteins reveals consequences for proteostasis and cell proliferation
Posttranslational mechanisms play a key role in modifying the abundance and function of cellular proteins. Among these, modification by advanced glycation end products (AGEs) has been shown to accumulate during aging and age-associated diseases but specific protein targets and functional consequence...
ORGANISM(S): Homo sapiens (Human) 
2021-11-25 | PXD021891 | Pride
Heart Acetylation Mass spectrometry Tubulin Kidney Mice Endothelial cell Cell cycle Microtubules Advanced glycation end products Carboxymethyllysine Mitosis Liver Glyoxal Proteasome Aging Posttranslational modification 
ProteomicsMapping sites of carboxymethyllysine modification on proteins reveals consequences for proteostasis and cell proliferation
Posttranslational mechanisms play a key role in modifying the abundance and function of cellular proteins. Among these, modification by advanced glycation end products (AGEs) has been shown to accumulate during aging and age-associated diseases but specific protein targets and functional consequence...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-25 | PXD021883 | Pride
Heart Acetylation Mass spectrometry Tubulin Kidney Mice Endothelial cell Cell cycle Microtubules Advanced glycation end products Carboxymethyllysine Mitosis Liver Glyoxal Proteasome Aging Posttranslational modification 
ProteomicsRegion-specific proteome changes of the intestinal epithelium during aging and dietary restriction
The small intestine is responsible for nutrient absorption and it is one of the most important interfaces between the environment and our body. During aging, changes in the structure of the epithelium lead to food malabsorption and reduced barrier function thus increasing disease risk in aging. The ...
ORGANISM(S): Mus musculus (Mouse) 
2020-04-29 | PXD014311 | Pride
Stem cell Crypts Diet Small intestine Aging 
Sort   by:  
 Page size