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UnknownNeolignans isolated from industrial hemp (Cannabis sativa L.) roots have cytotoxic effects on cancer cells.
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S-EPMC12357354 | biostudies-literature
ProteomicsEBV proteomics data - Identification of Epstein-Barr Virus Replication Proteins in Burkitt's Lymphoma Cells
A SILAC based experiment of cells infected or uninfected with EBV
ORGANISM(S): Homo sapiens (Human) 
2015-11-06 | PXD002461 | Pride
Human ebv 
ProteomicsMapping protein interactions in the active TOM-TIM23 supercomplex
Nuclear-encoded mitochondrial proteins destined for the matrix have to be transported across two membranes. The TOM and TIM23 complexes facilitate the transport of precursor proteins with N-terminal targeting signals into the matrix. During transport, precursors are recognized by the TIM23 complex i...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-12-13 | PXD028002 | Pride
Lc-msms Tim Mitochondria Translocation Structural modelling Tom23 Saccharomyces cerevisiae Crosslinking 
ProteomicsAdaptive resistance to Afatinib in non-small cell lung cancer cells in attenuated by Ca2+ depletion
Targeted therapies against oncogenic receptor tyrosine kinases are showing promising results in the clinic. However, despite the initial response, most patients become resistant. The majority of research regarding resistance has been focused on acquired resistance occurring after an extensive time o...
ORGANISM(S): Homo sapiens (Human) 
2018-10-02 | PXD008454 | Pride
Egfr  adaptive resistance  non-small lung cancer  tyrosine kinase inhibitors  calcium signaling 
ProteomicsHrp3-TAP_Purification from Schizosaccharomyces pombe
Hrp3_Purification from Schizosaccharomyces pombe 972h- Eukaryotic genome is composed of repeating units of nucleosomes to form chromatin arrays. A canonical gene is marked by nucleosome free region (NFR) at its 5’ end followed by uniformly spaced arrays of nucleosomes. In fission yeast we show both ...
ORGANISM(S): Schizosaccharomyces pombe 972h- 
2014-05-16 | PXD000041 | Pride
Schizosaccharomyces pombe 972h- _hrp3 
Proteomicsp65-HaloTag copurifying proteins in human 293T cells
In effort to develop methodology for targeted top down mass spectrometry of NF kappa B p65 from human cells, we evaluated the utility of HaloTag for purification and analysis of recombinant protein. During our study, two datasets of bottom up LC-MS/MS were generated: one from in-gel digestion of the...
ORGANISM(S): Homo sapiens (Human) 
2018-10-19 | PXD001932 | Pride
Rela 293t Human Nf kappa b P65 
ProteomicsLongitudinal serum proteomics of mother-infant dyads with HLA-conferred type 1 diabetes risk
LC-MS/MS analysis formula was performed for sera from 22 mother-infant dyads with HLA-conferred susceptibility to type 1 diabetes that were weaned to either an extensively hydrolyzed or regular infant milk. The samples included three samples from each mother (at the beginning of third trimester, at ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-27 | PXD046387 | Pride
Human Serum Lc-ms/ms 
ProteomicsSympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis
Various physiological stimuli, such as cold environment, diet, and hormones, trigger brown adipose tissue (BAT) to produce heat through sympathetic nervous system (SNS)- and -adrenergic receptors (ARs). The AR stimulation increases intracellular cAMP levels through heterotrimeric G proteins and aden...
ORGANISM(S): Mus musculus (Mouse) 
2018-07-12 | PXD009262 | Pride
Mouse Liver Mitochondria Label-free 
ProteomicsDissecting the functional selectivity of TGFβ signaling pathway components using genome engineered human organotypic skin models
Transforming growth factor β (TGFβ) signaling is essential in cell growth and differentiation. Yet, the role of the individual TGFβ signaling components in human tissue homeostasis and transformation is still incompletely understood. Here we dissected the importance of the core components in the TGF...
ORGANISM(S): Homo sapiens (Human) 
2023-02-09 | PXD024935 | Pride
Keratinocyte Proteomics Smad transcription factor Transforming growth factor beta (tgfβ) Organotypic skin culture Crispr/cas9 Phosphoproteomics 
ProteomicsProteome alteration in Myeloma, MGUS to MM transition
We have measured the proteomic changes on ANBL6, IH1, INA6, U266, KJON, OH2, VOLIN, LR5, KARPAS, RAMOS cell lines and used it to build a super SILAC library in order to quantify proteomic changes from MGUG to MM stages of Myeloma with Elite orbitrap mass spetrometer.
ORGANISM(S): Homo sapiens (Human) 
2024-06-07 | PXD006458 | Pride
Lr5 Oribitrap Volin Anbl6 Myeloma Oh2 U266 Silac Kjon Karpas Ih1 Super Ina6 Ramos 
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