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TranscriptomicsImmunoproteasome dysfunction augments alternative polarization of alveolar macrophages
The proteasome is a central regulatory hub for intracellular signaling by degrading numerous signaling mediators. Immunoproteasomes are specialized types of proteasomes known to be involved in shaping adaptive immune responses, but their role for innate immune signaling is elusive. Here, we analyzed...
ORGANISM(S): Mus musculus 
2016-06-29 | E-GEOD-72000 | biostudies-arrayexpress
UnknownIntertwined Precursor Supply during Biosynthesis of the Catecholate-Hydroxamate Siderophores Qinichelins in Streptomyces sp. MBT76.
Not available
S-EPMC5696649 | biostudies-literature
ProteomicsInvestigation of xylan degradation in Thermococcus sp. 2319x1E
Thermococcus sp. 2319x1E is able to grow on different mono- or polysaccharides as carbon source, including xylan. To investigate xylan degradation in Thermococcus sp. 2319x1E, cells were grown on 4 different carbon sources for 12 h (mid-exponential phase) and harvested by centrifugation. Using a lab...
ORGANISM(S): unclassified Thermococcus 
2022-02-17 | PXD026056 | Pride
Abpp Thermococcus sp 2319x1e Fp Fluorophosphonate 
ProteomicsNelfinavir overcomes proteasome inhibitor resistance in multiple myeloma by modulating lipid bilayer composition and fluidity
Nelfinavir has broad anti-cancer activity precilincally as a single agent and in combination. Clinically, it is particularly effective in the therapy of proteasome inhibitor-refractory multiple myeloma. The broad anti-cancer mechanism of action of nelfinavir implies that it may interfere with very f...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD023260 | Pride
Proteasome inhibitors Affinity-purification Upr Crispr/cas9 Adipor2 Ezetimibe Nelfinavir Hiv-protease inhibitor Multiple myeloma 
UnknownSkin barrier lipid enzyme activity in Netherton patients is associated with protease activity and ceramide abnormalities.
Not available
S-EPMC7269766 | biostudies-literature
UnknownChemical genetics strategy to profile kinase target engagement reveals role of FES in neutrophil phagocytosis.
Not available
S-EPMC7316778 | biostudies-literature
UnknownIn situ visualization of glucocerebrosidase in human skin tissue: zymography versus activity-based probe labeling.
Not available
S-EPMC5711493 | biostudies-literature
UnknownProgranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease.
Not available
S-EPMC5264254 | biostudies-literature
ProteomicsProteomics analysis of streptomyces sp. MBT76 demonstrates the production of qinichelins, new mixed catecholate-hydroxamate siderophores
Actinomycete genomes contain a plethora of orphan gene clusters encoding unknown secondary metabolites, and representing a huge unexploited pool of chemical diversity. The explosive increase in genome sequencing and the massive advance of bioinformatic tools have revolutionized the rationale for nat...
ORGANISM(S): Streptomyces sp. MBT76 
2018-10-24 | PXD006577 | Pride
Streptomyces Dimethyl labeling Siderophore Natural products Lc-msms 
UnknownRapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition.
Not available
S-EPMC4711871 | biostudies-literature
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