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TranscriptomicsThe differentiation/retrodifferentiation program of human U937 leukemia cells is accompanied by changes of VCP/p97
A possible functional role of VCP/p97 during differentiation of U937 cells was addressed by siRNA-targeting of VCP/p97. Functional changes in VCP-siRNA-transfected cells following phorbol ester-induced monocytic differentiation have been examind by DNA microarray analysis. Cells transfected with the...
ORGANISM(S): Homo sapiens 
2010-06-29 | E-GEOD-9821 | biostudies-arrayexpress
TranscriptomicsRNAi knock down of VCP in human HeLa cells
Study of the effects of the VCP knockdown. VCP (p97, yeast cdc48) is a hexameric AAA ATPase involved in various cellular functions including degradation of proteins by the ubiquitin-proteasome system. We examine the consequences of the reduction of VCP levels after RNAi of VCP in HeLa cells. We find...
ORGANISM(S): Homo sapiens 
2006-08-23 | E-MEXP-817 | biostudies-arrayexpress
ProteomicsBTG3-dependent VCP/p97 nuclear translocation is required for efficient repair of UV-induced DNA lesions
Skin exposure to ultraviolet (UV) rays from sunlight results in the formation of mutagenic DNA photolesions that are repaired by the nucleotide excision repair (NER) machinery. The inefficient repair of photolesions can lead to stalled DNA replication and mispairing, thereby causing strand breaks an...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD056446 | Pride
Phosphorylation Lc-ms/ms 
ProteomicsAP-SWATH analysis reveals a direct involvement of VCP/p97 in integrated stress response signalling through CReP/PPP1R15B degradation
The ubiquitin-directed AAA-ATPase VCP/p97 facilitates degradation of misfolded proteins in diverse cellular stress response pathways. Resolving the complexity of dynamic interactions with hosts of accessory proteins and substrates has therefore been a major challenge. Here, we used affinity-purifica...
ORGANISM(S): Homo sapiens (Human) 
2018-04-04 | PXD007876 | Pride
Integrated stress response Ap-swath P97 
ProteomicsVCF1 is a p97/VCP cofactor promoting recognition of ubiquitylated p97-UFD1-NPL4 substrates
The hexameric AAA+ ATPase p97/VCP functions as an essential mediator of ubiquitin-dependent cellular processes, extracting ubiquitylated proteins from macromolecular complexes or membranes by catalyzing their unfolding. p97 is directed to ubiquitylated client proteins via multiple cofactors, most of...
ORGANISM(S): Homo sapiens (Human) 
2024-03-14 | PXD043563 | Pride
Fam104a Vcf Vcp Ubiquitin P97 
TranscriptomicsHCT116 cells treated with the p97 inhibitior CB-5083
The goal of this study was to analyze differential gene expression 8 hr after treatment of CB-5083, a small molecule inhibitor of p97 (VCP), in HCT116 cells grown in culture. DMSO treated cells were compared to cells treated with 1uM CB-5083 after 8 hr.
ORGANISM(S): Homo sapiens 
2015-11-09 | E-GEOD-73588 | biostudies-arrayexpress
Proteomicsp97/VCP is required for piecemeal autophagy of aggresomes
Metazoan cells adapt to the exhaustion of protein quality control (PQC) systems by sequestering aggregation-prone proteins in large, pericentriolar structures termed aggresomes. Defects in both, aggresome formation and clearance affect proteostasis and have been linked to neurodegenerative diseases,...
ORGANISM(S): Homo sapiens (Human) 
2025-04-14 | PXD053581 | Pride
Aggrephagy Proximity proteomics Turboid Protein quality control Tax1bp1 P97/vcp Piecemeal autophagy 
Proteomicsp97/VCP promotes the recycling of endocytic cargo
The endocytic pathway is of central importance for eukaryotic cells, as it enables uptake of extracellular materials, membrane protein quality control and recycling, as well as modulation of receptor signaling. While the ATPase p97 (VCP, Cdc48) has been found to be involved in the fusion of early en...
ORGANISM(S): Homo sapiens (Human) 
2023-09-28 | PXD041169 | Pride
Myof Myoferlin Vcp Cdc48 P97 Rab11 
ProteomicsProteins co-localized with RNA Pol2 in ALS patient-derived neural precursors
Deficiency of proteostasis and RNA metabolism are increasingly recognized as critical drivers of neurodegenerative diseases. In this study, we focused on RNA polymerase II (Pol2) as the converging point of these two elements to understand how transcriptional machinery is affected by ALS-associated V...
ORGANISM(S): Homo Sapiens (human) 
2023-03-02 | PXD034483 | JPOST Repository
ProteomicsFunctional characterization of the p97/valosin-containing protein (VCP) interacting network in Leishmania Functional characterization of the p97/valosin-containing protein (VCP) interacting network in Leishmania
Valosin‐containing protein (VCP)/p97/Cdc48 is an essential AAA+ ATPase associated with many ubiquitin-dependent cellular pathways that plays a central role in protein quality control in all eukaryotes. Its functional diversity relies on its ability to cooperate with a large number of protein cofacto...
ORGANISM(S): Leishmania infantum JPCM5 
2020-08-06 | PXD013731 | Pride
Leishmania  vcp/p97  vcp cofactors  co-immunoprecipitation  lc-ms/ms  network proteomics 
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