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ProteomicsCab45-dependent facilitation of insulin secretory granule biogenesis and its dysregulation in type 2 diabetes
Germanos M1*. Yau B1*. Taper M1. An Y1. Yeoman C1. Wilson A1. Cattin-Ortolá J2. Maslar D3. Tong J1. Naghiloo S1. Needham E4. Diaz-Vegas A4. Larance M1. Thomas H5. Seidah NG6. von Blume J7. James DE4. Thorn P1. Ailion M2. Asensio C3. Kebede MA1. 1 School of Medical Sciences, Charles Perkins Centre, ...
ORGANISM(S): Rattus rattus (Black rat) 
2024-12-02 | PXD052042 | Pride
Islet Cab45 Insulin 
ProteomicsSystematic mapping of the adipocyte plasma membrane proteome reveals KCC1 and PIT2 as novel insulin-responsive transporters
The plasma membrane (PM) is a dynamic interface that integrates environmental cues with cellular responses. Insulin is known to remodel the PM primarily by stimulating the translocation of glucose transporter type 4 (GLUT4), but the full scope of this regulation remains poorly defined. Here, we perf...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-23 | PXD068305 | Pride
ProteomicsMulti tissue proteomic analysis of cold exposure
This study explored the proteomic basis of cold adaptation, quantifying 11,394 proteins across 6 metabolic tissues and plasma. Systems level analysis revealed an enrichment for proteins involved in metabolism. In brown adipose tissue (BAT), cold adaptation was associated with enhanced glucose utilis...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-22 | PXD055965 | Pride
White adipose Mouse Brown adipose Liver Muscle 
ProteomicsLeveraging genetic diversity to identify small molecules that reverse mouse skeletal muscle insulin resistance
Systems genetics has begun to tackle the complexity of insulin resistance by capitalising on computational advances to study high-diversity populations. “Diversity Outbred in Australia (DOz)” is a population of genetically unique mice with profound metabolic heterogeneity. We leveraged this variance...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-31 | PXD042277 | Pride
Insulin resistance Skeletal muscle Diversty outbred Mouse 
ProteomicsDeletion of the mitochondrial peptidase miPEP in adipose tissue protects against obesity and insulin resistance by increasing adaptive thermogenesis
Mitochondria are pivotal for cellular metabolism, serving as sources and targets of nutrient intermediates from converging metabolic pathways. Here, we demonstrate that insulin resistance leads to a marked alteration in the mitochondrial proteome of adipocytes. Analysis across multiple insulin resis...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-10 | PXD051606 | Pride
Insulin resistance Mipep Thermogenesis Adipose Mitochondria 
UnknownTankyrase modulates insulin sensitivity in skeletal muscle cells by regulating the stability of GLUT4 vesicle proteins.
Not available
S-EPMC5986224 | biostudies-literature
UnknownAcademic publisher guidelines on AI usage: A ChatGPT supported thematic analysis.
Not available
S-EPMC10844801 | biostudies-literature
UnknownGenetic variance in the murine defensin locus modulates glucose homeostasis.
Not available
S-EPMC12528722 | biostudies-literature
ProteomicsDeep proteome profiling of white adipose tissue reveals marked conservation and distinct features between different anatomical depots
The two major mammalian adipose tissue depots are subcutaneous adipose tissue (SAT), which is associated with metabolic protection, and abdominal/visceral (VAT), which contributes to metabolic disease. To investigate the molecular underpinnings of these differences, we conducted a comprehensive anal...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-13 | PXD039523 | Pride
Mouse Adipocytes Adipose tissue Visceral fat Subcutaneous fat 
UnknownPhosphOrtholog: a web-based tool for cross-species mapping of orthologous protein post-translational modifications.
Not available
S-EPMC4539857 | biostudies-literature
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