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Transcription of immediate early genes (IEGs) in response to extrinsic and intrinsic signals is tightly regulated at multiple stages. THOC5, a member of the TREX (transcription/export) complex plays a role in expression of only a subset of constitutively active genes. In this report, we show that TH...
ORGANISM(S): Mus musculus 

BACKGROUND: Protozoan Leishmania parasites are responsible for a range of clinical infections that represent a substantial challenge for global health. Amphotericin B (AmB) is increasingly used to treat Leishmania infection, so understanding the potential for resistance to this d...

2019-09-26 | MTBLS1167 | MetaboLights
A novel approach to recover and identify immune complexes (ICs) was developed using size exclusion chromatography (SEC) and affinity chromatography on immunoglobulin binding columns (HiTrap Protein G). The purification process was monitored by 1D SDS-PAGE, protein staining, Western blotting and, fin...
ORGANISM(S): Betainfluenzavirus Homo sapiens (Human) Alphainfluenzavirus 
2021-01-04 | PXD021575 | Pride
Inorganic nitrate (NO3-) has been proposed to be of therapeutic use as a dietary supplement in obesity and related conditions including the Metabolic Syndrome (MetS), type-II diabetes and metabolic dysfunction associated steatotic liver disease (MASLD). Administration of NO3- to endothelial nitric o...
2025-07-14 | MTBLS9526 | MetaboLights
BaF3 were transfected with Jak2 V617F, Jak2 K539L or Mpl W515L, shotgun proteomic analysis with iTRAQ was performed
ORGANISM(S): Mus musculus (Mouse) 
2016-05-26 | PXD002782 | Pride
Persistent mucosal inflammation and microbial infection are characteristic of Chronic Rhinosinusitis (CRS). Though mucosal microbiota dysbiosis is a characteristic feature of other chronic inflammatory diseases, the relationship between sinus microbiota composition and CRS is unknown. Here we demons...
ORGANISM(S): human nasopharyngeal metagenome 
Using a combination of GFP-trap affinity purification, native gel band identification and APEX2-mediated BioID pulse-chase analysis, we investigate an import pathway and folding mechanism for histones H3 and H4. We investigated proteins associating with H3 and H4 bearing mutations along alpha-helix ...
ORGANISM(S): Homo sapiens (Human) 
2022-09-15 | PXD029354 | Pride
Exposure to secondhand tobacco smoke during early childhood has been linked with an increased risk for behavioral disorders, yet little is known regarding how brain development is impacted. Using an environmental tobacco smoke (ETS) passive inhalation model, this study assesses the neurodevelopmenta...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-12-17 | PXD011744 | Pride
Exposure to secondhand tobacco smoke during early childhood has been linked with an increased risk for behavioral disorders, yet little is known regarding how brain development is impacted. Using an environmental tobacco smoke (ETS) passive inhalation model, this study assesses the neurodevelopmenta...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-05-26 | PXD007690 | Pride
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