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TranscriptomicsTHOC5 controls 3M-BM-4end-processing of immediate early genes via interaction with CPSF100
Transcription of immediate early genes (IEGs) in response to extrinsic and intrinsic signals is tightly regulated at multiple stages. THOC5, a member of the TREX (transcription/export) complex plays a role in expression of only a subset of constitutively active genes. In this report, we show that TH...
ORGANISM(S): Mus musculus 
2014-11-03 | E-GEOD-59561 | biostudies-arrayexpress
UnknownPhysician Assistant Students' Perception of Online Didactic Education: A Cross-Sectional Study.
Not available
S-EPMC9931029 | biostudies-literature
MetabolomicsUntargeted metabolomics to understand the basis of phenotypic differences in amphotericin B-resistant Leishmania parasites

BACKGROUND: Protozoan Leishmania parasites are responsible for a range of clinical infections that represent a substantial challenge for global health. Amphotericin B (AmB) is increasingly used to treat Leishmania infection, so understanding the potential for resistance to this d...

2019-09-26 | MTBLS1167 | MetaboLights
ProteomicsA proteomics-based method for identifying antigens within immune complexes
A novel approach to recover and identify immune complexes (ICs) was developed using size exclusion chromatography (SEC) and affinity chromatography on immunoglobulin binding columns (HiTrap Protein G). The purification process was monitored by 1D SDS-PAGE, protein staining, Western blotting and, fin...
ORGANISM(S): Betainfluenzavirus Homo sapiens (Human) Alphainfluenzavirus 
2021-01-04 | PXD021575 | Pride
Influenza Immune complexes Human Metaproteomics Orbitrap 
MetabolomicsChronic inorganic nitrate supplementation does not improve metabolic health and worsens disease progression in mice with diet-induced obesity.
Inorganic nitrate (NO3-) has been proposed to be of therapeutic use as a dietary supplement in obesity and related conditions including the Metabolic Syndrome (MetS), type-II diabetes and metabolic dysfunction associated steatotic liver disease (MASLD). Administration of NO3- to endothelial nitric o...
2025-07-14 | MTBLS9526 | MetaboLights
ProteomicsSCOPE 4 proteomics - Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells
BaF3 were transfected with Jak2 V617F, Jak2 K539L or Mpl W515L, shotgun proteomic analysis with iTRAQ was performed
ORGANISM(S): Mus musculus (Mouse) 
2016-05-26 | PXD002782 | Pride
Baf3 cell line transfected with a variety oncogenic linked mutations 
TranscriptomicsSinus Microbiome Plays a Primary Role in Rhinosinusitis
Persistent mucosal inflammation and microbial infection are characteristic of Chronic Rhinosinusitis (CRS). Though mucosal microbiota dysbiosis is a characteristic feature of other chronic inflammatory diseases, the relationship between sinus microbiota composition and CRS is unknown. Here we demons...
ORGANISM(S): human nasopharyngeal metagenome 
2012-07-31 | E-GEOD-37850 | biostudies-arrayexpress
ProteomicsHuman cell lines pulldown interactions CL-MSMS
Using a combination of GFP-trap affinity purification, native gel band identification and APEX2-mediated BioID pulse-chase analysis, we investigate an import pathway and folding mechanism for histones H3 and H4. We investigated proteins associating with H3 and H4 bearing mutations along alpha-helix ...
ORGANISM(S): Homo sapiens (Human) 
2022-09-15 | PXD029354 | Pride
Human Hek293-f Lc-msms Hela frt Warwick_rtp Histone chaperone Bioid 
ProteomicsMatrix stiffness drives alterations in aldehyde metabolism, inducing DNA damage and transformation
Microenvironmental stiffness regulates fundamental aspects of cell behaviour, including proliferation, differentiation and metabolism, many of which are implicated in cancer initiation and progression. In the mammary gland, extracellular matrix (ECM) stiffness, associated with high mammographic dens...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-04 | PXD063452 | Pride
Ecm Mechanosignalling Mammary epithelia 
ProteomicsEffect of Juvenile Environmental Tobacco Smoke Exposure on the Rat Frontal Cortex Neuroproteome
Exposure to secondhand tobacco smoke during early childhood has been linked with an increased risk for behavioral disorders, yet little is known regarding how brain development is impacted. Using an environmental tobacco smoke (ETS) passive inhalation model, this study assesses the neurodevelopmenta...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-12-17 | PXD011744 | Pride
Tobacco Juvenile Hdmse Neuroproteome Rat Brain Frontal Secondhand smoke Cortex Development 
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