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ProteomicsProteomic analysis upon miR195/497 replacement reveals potential chemo sensitizing candidates for colorectal cancer
Patients with advanced colorectal cancer (CRC) are commonly treated with systemic combination therapy but suffer eventually from drug resistance. MicroRNAs (miRNAs) are suggested to play a role in treatment resistance of CRC. We studied whether restoring downregulated miR-195-5p and 497-5p sensitize...
ORGANISM(S): Homo sapiens (Human) 
2019-09-27 | PXD015369 | Pride
Label-free Mirna Microrna Colorectal cancer 
ProteomicsHuman AML secretome and exosomes and correlation with Anti-Apoptotic Index, part 2
Expression of proteins regulating apoptosis (BCL-2, MCL-1, BCL-X and BAX) in acute myeloid leukemia (AML) blasts at diagnosis have been shown to be associated with disease-free survival. We previously found that the initially high apoptosis-resistance of AML cells decreased after therapy, while rega...
ORGANISM(S): Homo sapiens (Human) 
2016-02-03 | PXD003471 | Pride
Human Cell lysate Acute myloid leukemia Aml 
ProteomicsIdentification of differentially expressed splice variants by the proteogenomic pipeline SPLICIFY
Proteogenomics, i.e. comprehensive integration of genomics and proteomics data, is a powerful approach identifying novel protein biomarkers. This is especially the case for proteins that differ structurally between disease and control conditions. As tumor development is associated with aberrant spli...
ORGANISM(S): Homo sapiens (Human) 
2017-07-28 | PXD006486 | Pride
Human Proteogenomics Splicing Crc Label-free Colorectal cancer 
ProteomicsHuman AML secretome and exosomes and correlation with Anti-Apoptotic Index, part 3
Expression of proteins regulating apoptosis (BCL-2, MCL-1, BCL-X and BAX) in acute myeloid leukemia (AML) blasts at diagnosis have been shown to be associated with disease-free survival. We previously found that the initially high apoptosis-resistance of AML cells decreased after therapy, while rega...
ORGANISM(S): Homo sapiens (Human) 
2016-02-03 | PXD001487 | Pride
Human Exosome Extracellular vesicles Acute myloid leukemia Secretome Aml 
ProteomicsReproducibility of label-free single-shot phosphoproteomics applied to CRC cell lines
There is a need for robust phosphopeptide enrichment methods to allow signaling network analysis in cancer cell lines and tissues with minimal fractionation. With recent instrument developments thousands of unique phosphopeptides can be detected by single-shot LC-MS/MS. However, successful phosphopr...
ORGANISM(S): Homo sapiens (Human) 
2015-04-15 | PXD001546 | Pride
Human Single-shot Crc Label-free Phosphoproteomics Colorectal cancer 
OtherFeasibility of label-free phosphoproteomics and application to base-line signaling of colorectal cancer cell lines.
Data from ProteomeXchange, PXD ID: PXD001550. File: QE2_130117_OPL1013_TiOx_CRC_DLD1_3_130125023714.mzml. Published as part of J Proteomics. 2015 Apr 1. pii: S1874-3919(15)00103-7 . From the Abstract: {{i}} Robust phosphopeptide enrichment methods with minimal fractionation are required to profile ...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32320014765 | GPMDB
Resource Reanalysis 
ProteomicsSignaling networks transported by EVs drive phenocopying of migratory behavior between tumor cells
Tumors are heterogeneous with respect to mutational pattern, gene expression and microenvironment. This heterogeneity leads to large functional intratumoral differences in tumor cell behavior so that a tumor may contain or develop small fractions of cells that possess properties to migrate, metastas...
ORGANISM(S): Mus musculus (Mouse) 
2018-06-22 | PXD006439 | Pride
Ev Extracellular vesicle Label-free Tumor 
ProteomicsHS_CSF_microvesicles
Proteomics of cerebrospinal fluid microvesicles
ORGANISM(S): Homo Sapiens (human) 
2014-12-31 | PAe005110 | PeptideAtlas
ProteomicsTumor heterogeneity underlies differential cisplatin sensitivity in mouse models of small cell lung cancer
SCLC is the most aggressive subtype of lung cancer characterized by a remarkable response to chemotherapy followed by development of resistance. Mechanisms of initial sensitivity and of subsequent resistance are not understood. Here we highlight a broad tumor heterogeneity in mouse models of SCLC, w...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-12 | PXD010680 | Pride
Small-cell lung cancer Sclc Cisplatin Label-free Tumor 
ProteomicsProteolytic-independent role of mycosins in stabilization of the ESX-1 and ESX-5 type VII secretion membrane complexes.
Pathogenic mycobacteria contain up to five type VII secretion (T7S) systems, ESX-1 to ESX-5, which have central roles in virulence and viability. One of the conserved components of these systems, the serine protease mycosin (MycP), has been shown to be essential for secretion by ESX-1 and ESX-5. How...
ORGANISM(S): Mycobacterium marinum ATCC BAA-535 
2016-10-11 | PXD003766 | Pride
Mycobacterium marinum Tuberculosis Esx1 Single-shot Esx5 Label-free T7s 
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