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ProteomicsProteome of an early evolutionary stage photosynthetic organelle in the amoeba Paulinella chromatophora
The endosymbiotic acquisition of mitochondria and plastids >1 Ga ago profoundly impacted eukaryote evolution. Early stages of organelle integration however remain poorly understood. The amoeba Paulinella chromatophora contains more recently established cyanobacterium-derived photosynthetic organelle...
ORGANISM(S): Paulinella chromatophora 
2017-07-13 | PXD006531 | Pride
Organell evolution Evolution Model organism Endosymbiosis 
ProteomicsPsbS interacting proteins - PsbS interactions involved in the activation of energy dissipation in Arabidopsis
PsbS Protein Interactions during Non-photochemical quenching The non-photochemical quenching of excitation energy (NPQ) describes a photoprotective mechanism in the antenna of PSII which dissipates excess excitation energy as heat at the level of 1Chl* and by that prevents the formation of singlet o...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2016-01-12 | PXD002160 | Pride
Ap-ms Arabidopsis Psbs Lc-ms Thylakoid 
ProteomicsMining the secretome of C2C12 muscle cells
Secretome analysis faces several challenges, including detection of low abundant proteins and the discrimination of bona fide secreted proteins from false-positive identifications stemming from cell leakage or serum. Here, we developed a two-step secretomics approach and applied it for the analysis ...
ORGANISM(S): Mus musculus (Mouse) 
2018-01-24 | PXD007527 | Pride
Skeletal muscle cells Esi-lc-ms/ms Lspfp Proteolytic processing Secretome Plexin-b2 
ProteomicsProtein complexes between PGRMC1 and actin-associated proteins are disrupted by AG-205
PGRMC1 is a protein from the MAPR family with a range of cellular functions. PGRMC1 has been described to play a role in regulating membrane trafficking and in cancer progression and response to therapies. To further understand the functions of PGRMC1 and the mechanism of the small molecule inhibito...
ORGANISM(S): Homo sapiens (Human) 
2020-01-24 | PXD016455 | Pride
Ap-ms Cancer Pgrmc1 Trafficking 
ProteomicsThe proteome of APP/PS1 mouse amyloid beta oligomers
Amyloid β (Aβ) oligomers are thought to play an important role in the onset and progression of Alzheimer’s disease (AD). Several oligomer-binding proteins have been implicated in mechanisms leading to AD pathology. Such proteins could provide insights into the pathways involved in the disease proces...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-07 | PXD053785 | Pride
Alzheimer’s disease Co-immunoprecipitation Mass spectrometry Brain homogenates Amyloid beta oligomer binding App/ps1 mouse 
ProteomicsThe proteome of human amyloid beta oligomers
Amyloid β (Aβ) oligomers are thought to play an important role in the onset and progression of Alzheimer’s disease (AD). Several oligomer-binding proteins have been implicated in mechanisms leading to AD pathology. Such proteins could provide insights into the pathways involved in the disease proces...
ORGANISM(S): Homo sapiens (Human) 
2026-04-07 | PXD053759 | Pride
Alzheimer’s disease Co-immunoprecipitation Mass spectrometry Brain homogenates Amyloid beta oligomer binding 
ProteomicsSynechocystis sp. proteome on differnt light conditions
Cyanobacteria are an integral part of the Earth’s biogeochemical cycles and a promising resource for the synthesis of renewable bioproducts from atmospheric CO2. Sustainable industrial applications, however, are still scarce and the true limits of phototrophic production remain unknown. One of the l...
ORGANISM(S): Synechocystis sp. 
2019-01-07 | PXD009626 | Pride
Cyanobacteria Photorophic production Label-free quantification Synechocystis sp. pcc 6803 Lc-ms/ms Photobioreactor 
ProteomicsRedox proteome analysis identifies reversible oxidized proteins in retinoic acid differentiated SH-SY5Y cells
Retinoic acid stimulated SH-SY5Y cells are a common model system to study the initial phases of neuronal differentiation. Although these processes are associated with redox-sensitive processes, no comprehensive analysis of oxidative modified cysteines, as one of the main targets for reactive oxygen ...
ORGANISM(S): Homo sapiens (Human) 
2020-03-30 | PXD014381 | Pride
Dynamics Neuronal differentiation Redox Redox proteomics 
ProteomicsInhibitory effect of miR-183 on MCM family members
MYCN and HDAC2 jointly repress the transcription of tumor suppressive micro RNA miR-183 in neuroblastoma. Enforced miR-183 expression induces neuroblastoma cell death and inhibits anchorage-independent colony formation and subcutaneous xenograft growth in mice. We here aimed to unravel the miR-183 s...
ORGANISM(S): Homo sapiens (Human) 
2016-06-01 | PXD003596 | Pride
Label-free proteomics Cell cycle progression Eukaryotic genome replication Oncogene Genomic integrity 
ProteomicsBenchmarking of different methods for obtaining high quality secretomics data
The main drawback of secretome analyses are contaminating proteins derived from culture medium or proteins released from dying cells which are hard to distinguish from proteins actively secreted by cells. Therefore, several approaches have been applied allowing to remove contamination from secretome...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD018895 | Pride
Supernatant Secretomics Secreteome Benchmarking Conditioned medium 
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