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ProteomicsUSP14 inhibition enhances Parkin-independent mitophagy in iNeurons
Loss of proteostasis is well documented during physiological aging and depends on the progressive decline in the activity of two major degradative mechanisms: the ubiquitin-proteasome system (UPS) and the autophagy-lysosomal pathway. This decline in proteostasis is exacerbated in age-associated neur...
ORGANISM(S): Homo sapiens (Human) 
2024-12-18 | PXD056511 | Pride
Usp14 Mitophagy Autophagy Ups Parkin March5/mitol Pink1 
ProteomicsTargetable leukemia dependency on noncanonical PI3Kγ signaling
Phosphoinositide 3-kinase gamma (PI3Kγ) is implicated as a target to repolarize tumor-associated macrophages and promote anti-tumor immune responses in solid cancers. However, cancer cell-intrinsic roles of PI3Kγ are unclear. Here, by integrating unbiased genome-wide CRISPR interference screening wi...
ORGANISM(S): Homo sapiens (Human) 
2024-03-19 | PXD045702 | Pride
Leukemia Cancer Tmt Pi3kγ Pik3r5 Phosphoproteomics 
ProteomicsProteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer's disease
Aging is the most prominent risk factor for Alzheimer's disease (AD). However, the cellular mechanisms linking neuronal proteostasis decline to the characteristic aberrant protein deposits in AD brains remain elusive. Here, we develop transdifferentiated neurons (tNeurons) from 5 human dermal fibrob...
ORGANISM(S): Homo sapiens (Human) 
2024-12-20 | PXD059089 | Pride
Proteostasis Lysosome Alzheimer Neurons 
ProteomicsLiver RBFOX2 regulates cholesterol homeostasis via Scarb1 alternative splicing in mice
RNA alternative splicing (AS) expands the regulatory potential of eukaryotic genomes. The mechanisms regulating liver-specific AS profiles and their contribution to liver function are poorly understood. Here, we identify a key role for the splicing factor RNA-binding Fox protein-2 (RBFOX2) in mainta...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-28 | PXD036976 | Pride
Mouse Cholesterol Liver Splicing 
ProteomicsMulti-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals
Mitonuclear communication is essential to maintain cellular and organismal homeostasis in equilibrium and stress. Mitochondrial stress activates a concerted mitonuclear response geared to safeguard and repair mitochondrial function and to adapt cellular metabolism to the stress. However, the common ...
ORGANISM(S): Homo sapiens (Human) 
2017-06-01 | PXD006293 | Pride
Atf4 Omics Mitochondria Human Orbitral fusion 
ProteomicsThiol-Based Direct Threat Sensing by the Stress-Activated Protein Kinase Hog1
The stress-activated protein kinase Hog1 is best known for its role in osmotic stress but is also activated by a variety of mechanistically distinct environmental stressors including heat shock, ER stress, and arsenic. In the osmotic stress response, the signal is sensed upstream and relayed to Hog1...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-12-04 | PXD015325 | Pride
Arsenic stress Yeast Tmt 
ProteomicsMaternal iron deficiency modulates placental transcriptome and proteome in mid-gestation of mouse pregnancy
Background: Maternal iron deficiency (ID) is associated with poor pregnancy and fetal outcomes. The effect is thought to be mediated by the placenta but there is no comprehensive assessment of placental response to maternal ID. Additionally, whether the influence of maternal ID on the placenta diffe...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-12 | PXD023454 | Pride
Iron deficiency Gene expression Placenta 
ProteomicsGlobal proteomics of Ubqln2-based murine models of ALS
Familial neurodegenerative diseases commonly involve mutations that result in either aberrant proteins or dysfunctional components of the proteolytic machinery that acts on aberrant proteins. UBQLN2 is a ubiquitin receptor of the UBL/UBA family that binds the proteasome through its ubiquitin-like (...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-01-20 | PXD021991 | Pride
Proteomics Als Ubqln2 Proteasome Ubiquitin ligase Neurodegeneration Ubiquitin 
ProteomicsUbiquilin1 promotes antigen-receptor mediated proliferation by eliminating mislocalized mitochondrial proteins
Ubiquilins (Ubqlns) are a family of ubiquitin receptors that promote the delivery of hydrophobic and aggregated ubiquitinated proteins to the proteasome for degradation. We carried out a proteomic analysis of a B cell lymphoma-derived cell line, BJAB, that requires UBQLN1 for survival to identify UB...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-09-25 | PXD007610 | Pride
Mitochondrial Tmt Cytosol B cells 
ProteomicsAltered patterns of global protein synthesis and translational fidelity in RPS15-mutated chronic lymphocytic leukemia
Genomic studies have recently identified RPS15 as a new driver gene in aggressive and chemorefractory cases of chronic lymphocytic leukemia (CLL). RPS15 encodes a ribosomal protein whose conserved C-terminal domain extends into the decoding center of the ribosome. We demonstrate that mutations in hi...
ORGANISM(S): Homo sapiens (Human) 
2019-09-09 | PXD010924 | Pride
Chronic lymphocytic leukemia Translational fidelity Ribosomal decoding center Cll Rps15 Proteostasis 
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