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UnknownHow parents leverage guilt and pride: A comparison of parental guilt and pride induction in Hong Kong and the United States.
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S-EPMC12696220 | biostudies-literature
ProteomicsTranscriptional determinants of lipid mobilization in human adipocytes
Defects in white adipose tissue lipolysis drive multiple aspects of cardiometabolic disease but the transcriptional framework controlling this process has not been established. To address this, we performed a targeted perturbation screen in primary human adipocytes. Our analyses identified 37 transc...
ORGANISM(S): Homo sapiens (Human) 
2024-01-17 | PXD046964 | Pride
Coronary artery disease Lipolysis Type 2 diabetes Phosphodiesterase Znf189 Cad Pde1b2 T2dm Chip 
ProteomicsThe copper-induced viable-but-non-culturable state in Cupriavidus metallidurans CH34 is characterized by distinct proteomic response patterns- Part III
Copper-based materials are actively explored for their potential as antimicrobial agents. However, recent studies show that sublethal concentrations of Cu ions can induce the viable-but-non-culturable (VBNC) cell state in certain bacteria, hampering with contamination control and monitoring. Despite...
ORGANISM(S): Cupriavidus metallidurans CH34 
2025-05-07 | PXD056326 | Pride
Resuscitation Metabolism Metal resistance Dormancy Copper Lc-ms/ms 
ProteomicsPptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis
Mitochondrial proteins are replete with phosphorylation; however, the origin, abundance, and functional relevance of these modifications are largely unclear. Nonetheless, mitochondria possess multiple resident phosphatases, suggesting that protein dephosphorylation may be broadly important for mitoc...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-29 | PXD012743 | Pride
Mitochondia Pptc7 Phosphoproteome 
ProteomicsFunctional annotation of insulin-responsive genes in human adipocytes reveals PLCXD1 as a lipid storage regulator
Insulin regulates adipocyte biology partly by modulating gene expression, still many insulin-responsive targets remain uncharacterized. Here, we integrate three transcriptomic datasets to define insulin-regulated genes and assess their functions in human adipocytes using a multiparametric lipid turn...
ORGANISM(S): Homo sapiens (Human) 
2026-06-02 | PXD072248 | Pride
Phosphoinositide lipase Lipolysis White adipose tissue Adipocyte Insulin action Lipogenesis Plcxd1 Lipid turnover 
ProteomicsC-COMPASS: A user-friendly neural network tool profiles cell compartments at protein and lipid levels
Systematic proteomic organelle profiling methods including Protein Correlation Profiling and LOPIT have advanced our understanding of cellular compartmentalization. To manage the complexity of organelle profiling data, we introduce C-COMPASS, a user-friendly open-source software that employs a neura...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-07-18 | PXD056457 | Pride
Organelle proteomics 
ProteomicsA network-based approach reveals a novel mechanism of resistance to TKI-therapy in AML
Internal tandem duplications (ITDs) in the FLT3 gene are frequently identified and confer a poor prognosis in patient affected by acute myeloid leukemia (AML). The insertion site of the ITDs in FLT3 significantly impacts the sensitivity to tyrosine kinase inhibitors (TKIs) therapy, affecting patient...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD033953 | Pride
Tyrosine kinase inhibitors Ba/f3 cells Acute myeloid leukemia Midostaurin Flt3 Mouse Phosphoproteomics Tki Quizartinib Aml 
ProteomicsGlobal, neuronal, and beta-cell specific deletion of the insulin inhibitory receptor (inceptor) improves glucose homeostasis in diet-induced obese male mice
The insulin inhibitory receptor (inceptor) was recently identified as a key terminator of insulin and insulin-like growth factor 1 receptor (INSR/IGF1R) signaling in pancreatic 𝛽-cells12. Yet, the relevance of 𝛽-cell inceptor for glucose regulation through the INS1R/IGF1R axis has only been demons...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-17 | PXD046256 | Pride
Insulin inhibitory receptor Inceptor Insulin inceptor Diet-induced obesity Glucose homeostasis 
ProteomicsCarbo-loading in fungal lung pathogens: a quantitative analysis of CAZyme abundance and resulting glycan populations
Herein we i) identify Coccidioides spp.-specific CAZymes by bioinformatically comparing the CAZyme repertoire (CAZome) of Coccidioides spp. to other common fungal lung pathogens and a non-pathogenic close fungal relative, ii) experimentally evaluate Coccidioides spp. CAZyme abundance in vivo and in...
ORGANISM(S): Homo sapiens (Human) 
2019-11-11 | PXD012459 | Pride
Cazymes Proteomics Glycomics Coccidioides Glycans Valley fever 
ProteomicsA Spatiotemporal Proteomic Map of Human Adipogenesis
White adipocytes function as the major energy reservoir in humans by storing large amounts of triglycerides. Their dysfunction is associated with metabolic disorders. However, the mechanisms underlying cellular specialization during adipogenesis remain unknown. Here, we generated a spatiotemporal pr...
ORGANISM(S): Homo sapiens (Human) 
2024-01-17 | PXD047412 | Pride
Bcaa Slc25a10 Adipocyte Wat Sgbs Adipogenesis Pcp Proteomic ruler Ocm Mpan Organelle proteomics C19orf12 Human 
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