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ProteomicsA sensitive and cost-effective approach for tyrosine phosphoproteome analysis based on SH2 superbinder
Albeit much less abundant than Ser/Thr phosphorylation (pSer/pThr), Tyr phosphorylation (pTyr) is considered a hallmark in cellular signal transduction. However, its analysis remains a challenge. The conventional immunopurification (IP) approach using antibodies pan-specific to pTyr sites is known t...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-08-29 | PXD005838 | Pride
Lc ms/ms Sh2 superbinder Ptyr phosphoproteome 
ProteomicsPhosphoproteomics informed tailored low-dose drug combination strategies in Pancreatic ductal adenocarcinoma cell lines
Pancreatic ductal adenocarcinoma is a devastating disease with poor prognosis, commonly characterized by aberrant signaling. Phosphoproteomics provides a functional scaffold to unravel these complex signaling networks and to identify new targets. By a two-step sequential phospho-peptide enrichment, ...
ORGANISM(S): Homo sapiens (Human) 
2023-05-09 | PXD036951 | Pride
Pdac Imac Single shot Kinase Phosphoproteomics Ptyr ip Inka 
ProteomicsPhosphoproteomic analysis of the Folliculin (FLCN) tumor suppressor reveals FLCN-dependent kinase signaling and TFEB regulation
In Birt-Hogg-Dubé (BHD) syndrome, germline mutations in the Folliculin (FLCN) gene lead to an increased risk of renal cancer. To address if FLCN is involved regulating cellular signaling pathways via protein and receptor phosphorylation we determined comprehensive complete phosphoproteomic profiles ...
ORGANISM(S): Homo sapiens (Human) 
2022-07-11 | PXD025798 | Pride
Folliculin Flcn Renal cell carcinoma Phosphoproteomics Signaling Ptyr ip Inka 
ProteomicsHigh and low risk of adverse acute myeloid leukemia (AML)
LC-MS/MS raw files of proteomics, phosphoproteomics and pTyr-proteomics from patients with high and low risk of adverse AML
ORGANISM(S): Homo sapiens (Human) 
2021-01-04 | PXD019785 | Pride
Acute myeloid leukemia risk 
ProteomicsAlteration in Tyrosine Phosphorylation of Cardiac Proteome and EGFR Pathway Contribute to Hypertrophic Cardiomyopathy
Alterations of serine/threonine phosphorylation of the cardiac proteome are a hallmark of heart failure. However, the contribution of tyrosine phosphorylation (pTyr) to the pathogenesis of cardiac hypertrophy remains unclear. We use global mapping to discover and quantify site-specific pTyr in two c...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD036506 | Pride
Heart Tyrosine phosphorylation Proteomics Serine phosphorylation Threonine phosphorylation 
ProteomicsPhosphoproteomic Profiling of T-Cell Acute Lymphoblastic Leukemia Identifies Targetable Kinases and Combination Treatments
Protein kinase inhibitors are amongst the most successful cancer treatments, but targetable kinases activated by gene fusions are rare in T-ALL (e.g., NUP214-ABL1). Nevertheless, leukemic blasts rely on enhanced kinase signaling to sustain dysregulated proliferation. Protein kinases can be hyper-act...
ORGANISM(S): Homo sapiens (Human) 
2022-02-21 | PXD024807 | Pride
Human Single-shot T-all Ptyr Label-free Phosphoproteomics T-cell acute lymphoblastic leukemia 
ProteomicsBTN2A1 Targeting Reprograms M2-like Macrophages and TAMs via SYK and MAPK Signaling
Tumor-associated macrophages (TAMs), often adopting an immunosuppressive M2-like phenotype, correlate with unfavorable cancer outcomes. Our investigation unveiled elevated expression of the butyrophilin (BTN)2A1 in M2-like TAMs across diverse cancer types. We developed anti-BTN2A1 monoclonal antibod...
ORGANISM(S): Homo sapiens (Human) 
2024-09-02 | PXD055262 | Pride
Lc-msms Ap-ms Butyrophilin (btn)2a1 Reprogramming Mapk Immunosuppressive m2-like Syk Cancer 
ProteomicsPhosphoproteomics of truncated FGFR2, a clinically actionable oncogene in multiple cancers
Somatic hotspot mutations and structural amplifications and fusions affecting fibroblast growth factor receptor 2 (FGFR2) occur in multiple cancer types. However, clinical responses to FGFR inhibitors (FGFRi) have remained variable, emphasizing a need to better understand which FGFR2 alterations are...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-06 | PXD031711 | Pride
Cancer Fgfr2 Imac Mouse model Ptyrip Label-free Phosphoproteomics 
ProteomicsOptimized high-order drug mixtures improve colorectal carcinoma treatment via inactivationof MAP kinase signaling pathway and cell cycle alteration
Colorectal carcinoma is currently treated with a combination of chemotherapeutic drugs supplemented with targeted drugs. Since there is an eminent need to improved therapeutic success we employed the phenotypically-driven therapeutically guided multidrug optimization (TGMO) technology to identify pe...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD016604 | Pride
Human Combination therapy Ptyr ip Single-shot Phosphoproteomics Drug selection Colorectal carcinoma Phosphokinase ranking Label-free 
Proteomics[HPP-2.0] A tyrosine phosphoproteome analysis approach enabled by selective dephosphorylation with protein tyrosine phosphatase
Protein tyrosine phosphorylation (pTyr) plays a prominent role in signal transduction and regulation in all eukaryotic cells. In conventional immunoaffinity purification (IP) methods, phosphotyrosine peptides are isolated from the digest of cellular protein extracts with a phosphotyrosine-specific a...
ORGANISM(S): Homo Sapiens 
2023-09-26 | PXD045682 |
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