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ProteomicsEGF-dependent ubiquitinome, phosphorylation and interactome analysis in control and CYLD-deficient cells
Cylindromatosis tumor suppressor protein (CYLD) is deubiquitinase, best known as an essential negative regulator of the NFkB pathway. Previous studies have suggested an involvement of CYLD in epidermal growth factor (EGF)-dependent signal transduction as well, as it was found enriched within the tyr...
ORGANISM(S): Homo sapiens (Human) 
2017-06-05 | PXD006390 | Pride
Cyld Prm Hela Phosphorylation Egfr Ubiquitin 
ProteomicsDDI2 is a ubiquitin-directed endoprotease, responsible for cleavage of transcription factor NRF1
The Ddi1/DDI2 proteins are ubiquitin shuttling factors, implicated in a variety of cellular functions. In addition to ubiquitin-binding and ubiquitin-like domains, they contain a conserved region with similarity to retroviral proteases, but whether and how DDI2 functions as a protease has remained u...
ORGANISM(S): Homo sapiens (Human) 
2020-06-24 | PXD019152 | Pride
Ubisite Prm Ddi2 Ubiquitin Hph Lc-ms/ms 
ProteomicsFibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication in metabolic associated liver fibrosis
Liver fibrosis is a strong predictor of long-term mortality in patients with non-alcoholic fatty liver disease; yet the mechanisms underlying the progression from the comparatively benign fatty liver state to advanced non-alcoholic steatohepatitis (NASH) and liver fibrosis are incompletely under-sto...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-13 | PXD025691 | Pride
Prm Glis2 Liver fibrosis Elf3 Mouse Exploris 480 Nash 
UnknownWidespread Distribution of chs-1 Mutations Associated with Resistance to Diflubenzuron Larvicide in Culex pipiens Across Italy, Reaching Virtual Fixation in the Venetian Lagoon.
Not available
S-EPMC11856509 | biostudies-literature
ProteomicsTHE PROTEOME SPECIATION OF AN IMMORTALIZED CYSTIC FIBROSIS CELL LINE: NEW PERSPECTIVES ON THE PATHOPHYSIOLOGY OF THE DISEASE.
Cystic Fibrosis (CF) is a recessively inherited disease caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. CFTR has a pivotal role in the onset of CF, and several proteins are directly or indirectly involved in its homeostasis. To study these CFTR interactors...
ORGANISM(S): Homo sapiens (Human) 
2022-03-01 | PXD006933 | Pride
Cftr Cystic fibrosis Laminopathies 2d-dige Lc-ms/ms 
ProteomicsAdipose MDM2 regulates systemic insulin sensitivity through nuclear import of MORC2 and the PPARγ cofactor LIPIN1
The intimate association between obesity and type II diabetes urges for a deeper understanding of adipocyte function. We and others have previously delineated a role for the tumor suppressor p53 in adipocyte biology. Here, we show that mice haploinsufficient for MDM2, a key regulator of p53, in thei...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-15 | PXD020812 | Pride
Morc2 Obesity Pparγ C/ebp Mdm2 Lipin1 
UnknownSeismicity of the Gargano promontory (Southern Italy) after 7 years of local seismic network operation: Data release of waveforms from 2013 to 2018.
Not available
S-EPMC7841310 | biostudies-literature
UnknownNovel Amplicon-Based Sequencing Approach to West Nile Virus.
Not available
S-EPMC10305458 | biostudies-literature
UnknownAn amplicon-based sequencing approach for Usutu virus characterization.
Not available
S-EPMC11267690 | biostudies-literature
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