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ProteomicsSystem-level analysis of cancer and stomal cell specific proteomes reveals extensive reprogramming of phosphorylation networks by tumor microenvironment
DLD-1 cells and mouse were treated with DMSO, GDC0941 and CAL101 for 2 hours. Proteins were digested with trypsin and phospho peptides were enriched using TiO2. Enriched phosphopeptides and peptides were analysed by LTQ Orbitrap Velos mass spectrometer. (MS/MS data were converted to mgf files usin...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2014-04-02 | PXD000218 | Pride
Dld-1 cells Proteomics Phosphoproteomics 
ProteomicsFAK activity in cancer-associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer
Cancer-associated fibroblasts (CAFs), although considered as the most abundant pancreatic ductal adenocarcinoma (PDAC) stromal cells playing a critical role in tumor progression and chemoresistance, are not yet directly druggable. Here we report that focal adhesion kinase (FAK) activity (evaluated b...
ORGANISM(S): Homo sapiens (Human) 
2020-08-19 | PXD018899 | Pride
Fak Cancer-associated fibroblasts Pancreatic cancer Extracellular matrix 
ProteomicsIntegrative proteo-genomic profiling uncovers key biomarkers of lapatinib resistance in HER2-positive breast cancer
To understand the transcriptomic, genomic and proteomics changes between HER2 overexpressingcells and those that have become resistant to lapatinib
ORGANISM(S): Homo sapiens (Human) 
2025-11-17 | PXD056848 | Pride
3d Chromatin Proteomics Epigenetics Resistance Her2 Lc-ms/ms 
ProteomicsHuman omentum from patients with High-grade serous ovarian cancer
High-resolution multi-layered profiling of human ovarian cancer metastases.
ORGANISM(S): Homo sapiens (Human) 
2018-02-20 | PXD004060 | Pride
Lc-ms/ms Human Ovarian cancer Matrisome Extracellular matrix 
ProteomicsElucidation of BMI1, RYBP and H2AK119ub interactomes in Glioblastoma
Identification of BMI1, RYBP and H2AK119UB interactome in Glioblastoma (GBM) to elucidate BMI1 roles independent of the PRC1-complex in GBM.
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022057 | Pride
H2ak119ub Bmi1 Proteomics Glioblastoma Ipms Chipms Rybp Gbm Lc-ms/ms 
ProteomicsALOX12-expressing macrophages produce MCTRs to promote local efferocytosis and tissue repair
Poor wound healing due to dysregulated tissue repair responses can exacerbate and prolong disease. Successful tissue repair is critically dependent on the timely clearance of apoptotic cells by macrophages in a process termed efferocytosis. Mechanisms and factors that link these two fundamental proc...
ORGANISM(S): Homo sapiens (Human) 
2023-12-12 | PXD038390 | Pride
Alox12 Macrophages Phosphoproteomics Lc-ms/ms 
ProteomicsComputational analysis of cholangiocarcinoma phosphoproteomes identifies patient-specific drug targets
We used mass-spectrometry based phosphoproteomics and computational methods to identify patient-specific drug targets in primary CCA and CCA-derived cell lines. We analyzed 13 primary CCA with matched background tissue and 8 different cell lines leading to the identification and quantification of >1...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD027329 | Pride
Cholangiocarcinoma 
ProteomicsSFX-01 is therapeutic against myeloproliferative disorders caused by activating mutations in Shp2
• Activating mutations of Shp2 cause conditions such as Noonan syndrome and juvenile myelomonocytic leukemia (JMML), with unmet therapeutic needs. • SFX-01, a sulforaphane complex, modifies cysteine residues and targets proteins including Shp2, where it induces an inhibitory modification at the acti...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-12 | PXD061655 | Pride
Shp2 Sfx-01 Myeloid cell proliferation Noonan syndrome Phosphoproteomics Lc-ms/ms 
ProteomicsECM-enriched proteomics of human fallopian tube, fimbria and ovarian tissue
We analysed the extracellular matrix (ECM) landscape of fresh, healthy tissues from human fallopian tube (FT), fimbria (FB, the tissue of origin of serous tubal intraepithelial lesions) and ovarian tissue (OV). The aim was to identify differentially expressed matrix proteins between FB and FT or OV ...
ORGANISM(S): Homo sapiens (Human) 
2022-06-20 | PXD023912 | Pride
Ecm Ovarian cancer Tgfbi Fallopian tube Fimbria Ovary 
ProteomicsEffects of FTY720 on phospho-proteome of leukemic cells
: FTY720 (Fingolimod) is an immunosuppressive drug approved by FDA for Multiple Sclerosis (MS), that has gained attention as anti-cancer drug, thanks to its ability to disrupt the binding between the onco-protein SET and the tumor- suppressor phosphatase PP2A. We investigated FTY720 induced phospho...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD038288 | Pride
Fty720 Pp2a Phosphoproteomics Set Fingolimod Aml Lc-ms/ms 
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