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ProteomicsArginine Methylation Regulates SARS-CoV-2 Nucleocapsid Protein Function and Viral Replication
Viral proteins are known to be methylated by host protein arginine methyltransferases (PRMTs) playing critical roles during viral infections. Herein, we show that PRMT1 methylates SARS-CoV-2 nucleocapsid (N) protein at residues R95 and R177 within RGG/RG sequences. Arginine methylation of N protein ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025763 | Pride
Prmt1 Sars-cov-2 Rna binding Stress granules Nucleocapsid (n) protein Arginine methylation Type i prmt inhibitor Condensate Rgg/rg motif 
MetabolomicsStage-specific metabolic responses in blue mussels to marine shipping-related acoustic and chemical stressors revealed by nuclear magnetic resonance

Maritime traffic exposes coastal organisms to both acoustic disturbance and chemical pollution, yet how these stressors affect and interact across early developmental stages remains poorly understood. We investigated stage-specific metabolic responses of blue mussel (Mytilus edulis) larv...

2026-06-15 | MTBLS13945 | MetaboLights
ProteomicsSzewczyk_InhibitionOfPRMT7_P36_2020
This dataset consists of 16 raw MS files, acquired on Orbitrap Fusion Lumos Tribrid mass spectrometer operated in Data Dependent Acquisition (DDA) mode for the 8 input files and DDA with simultaneous parallel reaction monitoring (targeted masses; 599.33, 604.33, 608.23, 606.33, 407.89, 403.22, 651.3...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-01-08 | MSV000084773 | MassIVE
ProteomicsRNA polymerase II transcription with partially assembled TFIID complexes
RNA polymerase II (Pol II) transcription initiation starts with the assembly of the preinitiation complex (PIC) on core promoters. The PIC is composed of six general transcription factors (GTFs). The recognition of the core promoter sequences by the TFIID GTF complex is the first step of the PIC ass...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-21 | PXD046459 | Pride
Transcription Rna polymerase Tfiid 
ProteomicsCD9, a key mediator of pancreatic cancer cell aggressiveness driven by CAFs-derived extracellular vesicles
While of growing interest in pancreatic cancer (PC) field, the stromal-tumor cells crosstalk lags behind in terms of biomarkers and therapeutic options improving the clinical armamentarium. Knowledge on cellular communications was drastically enhanced following the discovery of extracellular vesicle...
ORGANISM(S): Homo sapiens (Human) 
2022-08-21 | PXD023165 | Pride
Lc-msms Cd9 Migration Cancer-associated fibroblasts (cafs) Extra-cellular vesicles (evs) P38/mapk pathway Stromal compartment Pancreatic cancer (pc) 
ProteomicsThe impact of tumor cell-derived extracellular vesicles on primary PDAC cancer-associated fibroblast matrisomes
To investigate the impact of tumor-cell derived extracellular vesicles (EVs) on cancer-associated fibroblasts (CAFs) secretory phenotypes, CAFs were treated with pancreatic cancer cell line-derived EVs and produced extracellular matrices (ECM). ECMs denuded of cells were analyzed by mass spectrometr...
ORGANISM(S): Homo sapiens (Human) 
2026-06-11 | PXD039279 | Pride
Lc-msms Extracellular vesicles Matrisome Extracellular matrix Pdac 
ProteomicsProteomic profile of healthy human monocytes differentiated to macrophages with non-tumor or tumor cell-derived extracellular vesicles
To investigate the impact of tumor cell-derived extracellular vesicles on monocyte-macrophage differentiation, healthy monocytes were treated with EVs derived from two different pancreatic cancer cell lines and a non-tumoral pancreatic ductal epithelial cell line. Following differentiation to macrop...
ORGANISM(S): Homo sapiens (Human) 
2026-06-11 | PXD039439 | Pride
Lc-msms Monocytes Tumor-associated macrophages Extracellular vesicles Immunosuppression 
TranscriptomicsThe role of carbon starvation in the induction of enzymes that degrade plant-derived carbohydrates in Aspergillus niger
Fungi are an important source of enzymes for saccharification of plant polysaccharides and production of biofuels. Understanding of the regulation and induction of expression of genes encoding these enzymes is still incomplete. To explore the induction mechanism, we analysed the response of the indu...
ORGANISM(S): Aspergillus niger 
2014-08-22 | E-GEOD-57315 | biostudies-arrayexpress
UnknownIntegrating artificial intelligence into lung cancer screening: a randomised controlled trial protocol.
Not available
S-EPMC10868245 | biostudies-literature
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