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ProteomicsMacrophage Responses to Helicobacter pylori
The purpose of this study was to examine macrophage proteomic changes induced by Helicobacter pylori. Macrophages utilized were the RAW 264.7 murine cell line. Macrophages were treated with H. pylori for 24 hours. The experimental design was a 4-plex isobaric tags for relative and absolute quantific...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD010082 | Pride
Proteomics Macrophages Immune response Helicobacter pylori 
ProteomicsHyperactive Mouse Serotonin Transporter Interacting Proteins LC-MSMS
The serotonin (5-HT) transporter (SERT) is a key determinant of the concentration of 5-HT available for synaptic signaling and is the target of the antidepressant-selective 5-HT reuptake inhibitors (SSRIs). In addition to the role of SERT in mediating the actions of antidepressant medications, multi...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-29 | PXD018695 | Pride
Lc-msms Mouse Serotonin transporter interacting proteins Midbrain 
ProteomicsEffect of Dhps deletion on macrophage activation by Helicobacter pylori
Bone marrow-derived macrophages from Dhps fl/fl mice and mice with specific deletion of Dhps in myeloid cells were infected with Helicobacter pylori PMSS1 for 24 hours. Cells were washed and lysed. Proteins were analyzed by isobaric tags for relative and absolute quantitation (iTRAQ).
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD018187 | Pride
Macrophage Bacterial infection Helicobacter pylori 
ProteomicsDevelopmental proteomics of wild-type and K6W-Ub mouse congenital cataractous lenses
Whole lenses were dissected from E15.5, P1, or P30 wild-type C57BL/6J mice or from K6W-Ub transgenic mice, which develop congenital cataracts. Lens homogenates were subjected to quantitative proteomic analysis using tandem mass tag (TMT) isobaric labeling.
ORGANISM(S): Mus musculus (Mouse) 
2023-09-14 | PXD045040 | Pride
Lens proteomics Cataract Ubiquitin 
ProteomicsQuantitative Proteomic Analysis of Extracellular Vesicles Derived from γ-Irradiated Normal Human Breast Fibroblasts
Small extracellular vesicles (EVs) were isolated from a model of normal breast fibroblasts— immortalized cells derived from healthy reduction mammoplasty tissue—treated with γ-radiation to study the effects of radiation therapy on intercellular communication within the breast stroma. EVs were isolat...
ORGANISM(S): Homo sapiens (Human) 
2026-03-02 | PXD063788 | Pride
Extracellular vesicles Comparative proteomics Tmt labeling Ionizing radiation Label-free quantification 
ProteomicsReplisome composition of stalled, terminating replication forks
Topological stress can cause replication forks to stall as they converge upon one another during termination of vertebrate DNA synthesis. However, replication forks ultimately overcome topological stress and complete DNA synthesis, suggesting that alternative mechanisms can overcome topological stre...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2023-02-21 | PXD031170 | Pride
Xenopus Lc-msms Topoisomerase Egg extracts Termination Dna replication 
ProteomicsTandem Mass Tag-Based Quantitative Proteomics of Extracellular Vesicles Isolated from Mammary Fibroblasts Treated with γ-radiation
Small extracellular vesicles (EVs) were isolated from a model of normal breast fibroblasts— immortalized cells derived from healthy reduction mammoplasty tissue—treated with γ-radiation to study the effects of radiation therapy on intercellular communication within the breast stroma. EVs were isolat...
ORGANISM(S): Homo sapiens (Human) 
2026-06-01 | PXD066811 | Pride
Proteomics Extracellular vesicles Tmt-based quantification Ionizing radiation 
ProteomicsAnalysis of the proteome of epithelial cells from mice with specific deletion of DHPS
Colonic epithelial cells from 3 Dhpsfl/fl;Vil1cre/+ mice and 3 Dhpsfl/fl mice were isolated, cells were lysed, and proteins were extracted and processed for quantitative proteomics analysis using tandem mass tags (TMT).
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD033228 | Pride
Hypusine  polyamines  colitis  colorectal cancer  colonic epithelial cells 
ProteomicsEffect of Dhps deletion and Citrobacter rodentium on the proteome of colonic epithelial cells
Dhps mice and Dhps;Vil1 mice were infected or not with Citrobacter rodentium (10^9 bacteria/mouse) for 14 days, and cell lysates were prepared for analysis. A total of 4 mice per group were used for the following groups: (1) Vil1<+> no C. Rod; (2) Vil1 no C. Rod; (3) Vil1<+...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD051536 | Pride
Polyamines  hypusine  translation  infection  attaching and effacing pathogen  colitis  mucosal immune response  host-pathogen interactions  proteomics 
ProteomicsRegulation by hypusination of the proteome of GECs during H. pylori infection
Mice with or without specific deletion of the gene Dhps in intestinal epithelial cells were infected (n = 2 per genotype) or not (n = 2 per genotype) with Helicobacter pylori PMSS1 for 8 weeks. Proteins from isolated gastric epithelial cells (GECs) were extracted and analyzed using a TMT-based prote...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-01 | PXD069622 | Pride
Infection  gastritis  polyamine  quantitative proteomics 
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