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ProteomicsProteomic responses of Candida albicans to Galleria mellonella larvae hemolymph
This study assessed the development of disseminated candidiasis within Galleria mellonella larvae and characterised the proteomic responses of Candida albicans to larval hemolymph. Infection of larvae with an inoculum of 1 × 106 yeast cell reduced larval viability 24 (53.33 ± 3.33%), 48 (33.33 ± 3....
ORGANISM(S): Candida albicans (Yeast) 
2019-01-17 | PXD011997 | Pride
Candida  galleria Infection Immunity In vivo screening Mini-model 
ProteomicsThe acute host – pathogen interactions between Aspergillus fumigatus and Galleria mellonella
Larvae of the greater wax moth Galleria mellonella are an ideal in vivo model to quickly and easily assess the virulence of a range of human pathogens, to comprehensively analyse the host – pathogen interactome and to reproducibly evaluate the in vivo toxicity and efficacy of anti-microbial agents. ...
ORGANISM(S): Galleria mellonella 
2018-06-21 | PXD008196 | Pride
Galleria aspergillus virulence infection mini-model 
ProteomicsProteomic analysis of the processes leading to Madurella mycetomatis grain formation in Galleria mellonella larvae
Mycetoma is a neglected chronic and granulomatous infection primarily associated with the fungal pathogen Madurella mycetomatis. Infection is characterised by the formation of fungal grains inside the infected tissue which commonly result in severe deformity and disability. Currently the biochemical...
ORGANISM(S): Galleria mellonella Madurella mycetomatis 
2020-03-19 | PXD013532 | Pride
Infection Immunity Grain Madurella  galleria In vivo screening Proteomics Mini-model 
ProteomicsAnalysis of the early cellular and humoral responses of Galleria mellonella larvae to infection by Candida albicans
Galleria mellonella larvae were administered an inoculum of Candida albicans and the cellular and proteomic response to infection over the first 24 hours was monitored. The yeast cell density in infected larvae declined initially but replication commenced six hours post-infection. The hemocyte densi...
ORGANISM(S): Galleria mellonella 
2017-09-06 | PXD006879 | Pride
Candida  galleria Ms/ms Infection Immunity In vivo screening Quantatitive Q-exactive Mini-model 
ProteomicsThe human cathelicidin antimicrobial peptide LL-37 promotes the growth of the pulmonary pathogen Aspergillus fumigatus.
Aspergillus fumigatus contributes to invasive and allergic pulmonary disease in immunocompromised individuals. The pulmonary mucus of cystic fibrosis (CF) patients displays elevated levels of the pleiotropic cathelicidin antimicrobial peptide LL-37 and the aim of this work was to assess the effect o...
ORGANISM(S): Aspergillus fumigatus var. fumigatus 
2018-05-22 | PXD008143 | Pride
Growth Ll-37 Aspergillus Antimicrobial 
ProteomicsResponse of Galleria to co-infection by Candida and Staphylococcus.
Polymicrobial infections are intrinsically less susceptible to antimicrobial therapy, are more invasive and can induce enhanced inflammatory responses leading to negative clinical outcomes. The importance of studying the interaction between microbes themselves and their interactions with their host ...
ORGANISM(S): Galleria mellonella 
2020-02-24 | PXD014273 | Pride
Infection Galleria Immunity Staphylococcus Co-infection. anti-microbial Candida Mini-model 
ProteomicsUtilisation of Galleria mellonella larvae to characterise development of Staphylococcus aureus infection
Staphylococcus aureus is a common human opportunistic pathogen which causes a wide range of infections from superficial skin infections to invasive infections including pneumonia and bloodstream infections. Here we describe how an inoculum of S. aureus activates the cellular and humoral response of ...
ORGANISM(S): Galleria mellonella 
2019-05-21 | PXD012766 | Pride
Infection Immunity Staphylococcus : galleria Mini-model 
ProteomicsHumoral Immune response of Galleria mellonella to BCG and APP
The humoral immune response of Galleria mellonella exposed to Mycobacterium bovis BCG (vaccine strain), 1x107 CFU (10 ul inoculum) were injected into the larvae. For low dose BCG challenge, 1x105 CFU (10 ul) were injected. For larval challenge with Actinobacillus pleuropneumoniae (APP), ~1.5x106 CFU...
ORGANISM(S): Galleria mellonella 
2021-09-08 | PXD015250 | Pride
Lc-ms/ms Galleria mellonella Proteomics Innate immune response Humoral Mycobacterium 
ProteomicsAnalysis of the effect of atorvastatin on the growth of Aspergillus fumigatus
The filamentous fungus Aspergillus fumigatus is the cause of a variety of pulmonary infections (chronic pulmonary aspergillosis) and life-threatening systemic infection that can infect a variety of different organs (invasive aspergillosis). A. fumigatus is widely distributed in the environment and ...
ORGANISM(S): Neosartorya fumigata (Aspergillus fumigatus) 
2021-09-08 | PXD015254 | Pride
Aspergillus fumigatus Gliotoxin Ergosterol Atorvastatin 
UnknownPrevalence of Celiac Disease in 52,721 Youth With Type 1 Diabetes: International Comparison Across Three Continents.
Not available
S-EPMC6463736 | biostudies-literature
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