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ProteomicsInactivation of Influenza A virus under expiratory aerosol conditions is mediated by structural protein changes, as determined by whole virus mass-spectrometry.
Multiple respiratory viruses including Influenza A virus (IAV) can be transmitted via expiratory aerosol particles, and many studies have established that environmental conditions can affect viral infectivity during airborne transmission. Low aerosol pH was recently identified as a major factor infl...
ORGANISM(S): Influenza A virus (A/WSN/1933(H1N1)) 
2023-08-10 | PXD037176 | Pride
Influenza Heamaggluttinin Ph Hdx-ms Hatrix protein 1 
ProteomicsConoid extrusion serves as gatekeeper for entry of glideosome components into the pellicular space to control motility and invasion in Apicomplexa
Members of the apicomplexans are defined by apical cytoskeletal structures and secretory or-ganelles, tailored for motility and invasion. Gliding is powered by the actomyosin-dependent rearward translocation of apically secreted transmembrane adhesins. In Toxoplasma gondii, the conoid, composed of a...
ORGANISM(S): Toxoplasma gondii GT1 
2023-08-31 | PXD031816 | Pride
Apicomplexa Conoid extrusion Egress Motility Alphafold F-actin Invasion Toxoplasma gondii Hdx-ms Plasmodium berghei Preconoidal rings Micronemes 
ProteomicsNative State Stabilization is an Effective Strategy to Inhibit TDP-43 Oligomerization and Fibrillogenesis
Transactive response DNA-binding protein 43 kDa (TDP-43) is a partially disordered nuclear protein that plays essential roles in RNA metabolism to maintain cellular homeostasis. In individuals with neurodegenerative diseases (NDDs), including Amyotrophic lateral Sclerosis (ALS), Alzheimer’s disease,...
ORGANISM(S): Homo sapiens (Human) Bacteria 
2026-06-24 | PXD041160 | Pride
Hdx-ms Aggregation Neuronal toxicity Oligonucleotides Tar dna binding protein (tdp-43) 
ProteomicsArchitecture of the MKK6-p38α complex defines the basis of MAPK specificity and activation
The MAP kinase p38α is a central component of signalling in inflammation and the immune response, and is therefore an important drug target. Little is known about the molecular mechanism of its activation by double-phosphorylation from MAP2Ks, due to the challenge of trapping a transient and dynamic...
ORGANISM(S): Homo sapiens (Human) 
2023-08-31 | PXD040499 | Pride
Kinases Hdx-ms Molecular dynamics Mapk Cryo-em Mkk6 
ProteomicsAn inhibitory segment within G-patch activators tunes Prp43-ATPase activity during ribosome assembly
Mechanisms by which G-patch activators tune the processive multi-tasking ATP-dependent RNA helicase Prp43 to remodel diverse RNA:protein complexes remain elusive. Here, a comparative study between a new activator, Tma23, and a characterized activator, Pxr1, uncovered segments that organize Prp43 fun...
ORGANISM(S): Saccharomyces cerevisiae Saccharomyces cerevisiae (Baker's yeast) 
2024-10-09 | PXD046892 | Pride
Ribosome assembly Prp43 Cryo-em Hdx-ms Rna helicase 
ProteomicsAutoregulation of tubulin mRNA via reversible TTC5 sequestration by soluble ab-tubulins
Microtubule cytoskeleton, built from heterodimers of α and β-tubulins, is critically important to physically organize cells, mediate intracellular transport and power cell division. The availability of soluble αβ-tubulins influences the biomechanical properties and functions of microtubules. When pr...
ORGANISM(S): Homo sapiens (Human) 
2024-10-18 | PXD050483 | Pride
Microtubules Ttc5 Hdx-ms Mrna Tubulin 
ProteomicsA GAF domain mediates inositol pyrophosphate substrate channeling in PPIP5K phosphatases
Inositol pyrophosphates are highly phosphorylated nutrient messengers. The final step of their biosynthesis is catalyzed by diphosphoinositol pentakisphosphate kinase (PPIP5K) enzymes, which are conserved among fungi, plants, and animals. PPIP5Ks contain an N-terminal kinase domain that generates th...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-10-07 | PXD056020 | Pride
Inositol pyrophosphate Schizosaccharomyces pombe Histidine acid phosphatase Arabidopsis thaliana. hdx-ms Phytase Saccharomyces cerevisiae Enzyme mechanism Phosphate homeostasis Gaf domain Inositol pyrophosphate phosphatase 
ProteomicsMolecular basis of mitogen-activated protein kinase ERK2 activation by its upstream kinase MEK1
The RAS-RAF-MEK-ERK mitogen-activated protein kinase (MAPK) pathway relays extracellular signals into a cellular response by activation of transcription factors and other protein kinases. The pathway regulates functions such as cell proliferation and growth, with mutations in various nodes found in ...
ORGANISM(S): Homo sapiens (Human) 
2026-10-20 | PXD073252 | Pride
Mapks Cell signaling Kinases Hdx-ms Regulation 
ProteomicsPI3Kdelta is selectively inhibited by roginolisib through stabilizing of the C-terminal helix ka12
Phosphoinositide 3-kinases (PI3Ks) are major regulators of cell growth, proliferation and signalling, constituting key therapeutic targets in cancer, inflammation, and other diseases. Individual class I PI3K isoforms control non-redundant cellular functions, imposing the need to generate isoform-spe...
ORGANISM(S): Homo sapiens (Human) 
2026-06-24 | PXD071872 | Pride
Phosphoinositide 3-kinase Structure Pi3k Roginolisib Hdx-ms Lipid signalling Inhibition 
ProteomicsIdentification of RON13 binding with with RON4 substrate
Active host cell invasion by the obligate intracellular apicomplexan parasites relies on the formation of a moving junction (MJ), which joins parasite and host cell plasma membranes during entry. Invading Toxoplasma gondii tachyzoites secrete a complex of RON proteins from the rhoptry organelles tha...
ORGANISM(S): Toxoplasma gondii GT1 
2021-05-10 | PXD023791 | Pride
Ron13 Toxoplasma gondii Secretory pathway Hdx-ms Kinase 
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