Sort   by:  
 Page size 
ProteomicsIdentification of neoantigens in oesophageal adenocarcinoma
We present data from tissues of seven oesophageal adenocarcinomas of CD4 and CD8 T cell epitopes eluted from the cell surface using mass spectrometry (immunopeptidomics) of presented HLA bound peptides.This dataset forms part of the publication:Nicholas, B., Bailey, A., McCann, K.J., Wood, O., Walke...
ORGANISM(S): Homo sapiens (Human) 
2022-09-27 | PXD031108 | Pride
Human Oesophageal adenocarcinoma Immunopeptidome Hla 
ProteomicsMetabolic changes in adaptation to biofilm growth by streptococcus pneumoniae
Comparative analyses of protein expression between log-phase planktonic and 1-day and 7-day biofilm cultures from Streptococcus pneumoniae representing nascent and late phase biofilm growth were performed using the proteomic approach iTRAQ
ORGANISM(S): Streptococcus pneumoniae SP14-BS69 
2014-09-10 | PXD001182 | Pride
Biofilm Streptococcus pneumoniae 
ProteomicsBi-directional epithelial-mesenchymal crosstalk provides self-sustaining pro-fibrotic signals in pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is the prototypic progressive fibrotic lung disease with a median survival of 2-4 years. Injury to and/or dysfunction of alveolar epithelium are strongly implicated in IPF disease initiation, but what factors determine why fibrosis progresses rather than normal ti...
ORGANISM(S): Homo sapiens (Human) 
2021-08-19 | PXD025821 | Pride
Tgf-β Ras Secretome Proteomics 
ProteomicsLarge-scale HDMSE mapping of the normal sputum proteome
Severe asthma is a collection of disease entities with varying pathophysiological characteristics that result in symptoms of cough, wheeze and breathlessness, with frequent exacerbations. To address the problem of phenotypic difference and heterogeneity, the Unbiased Biomarkers for the Prediction of...
ORGANISM(S): Homo sapiens (Human) 
2018-05-14 | PXD005949 | Pride
Label free Data independent Human Sputum 
ProteomicsAn integrated model system to study biofilm-associated adaptation to antimicrobials and resistance evolution in Pseudomonas aeruginosa MPAO1
Using an integrated model system for reproducible growth of biofilms, a JPIAMR-funded consortium of researchers* studied the expressed proteome of P. aeruginosa strain MPAO1 under i) planktonic growth, and ii) biofilm formation conditions. The model system included, as a first step, the sequencing a...
ORGANISM(S): Pseudomonas aeruginosa 
2021-09-09 | PXD017122 | Pride
Comparative genomics Strain mpao1 Planktonic Biofilm Flow chamber Colistin Proteogenomics Shotgun proteomics Transposon sequencing Antibiotic resistance related proteins Genome sequencing Antimicrobials P. aeruginosa 
ProteomicsAnnexin A1 is a polarity cue that directs planar mitotic spindle orientation during mammalian epithelial morphogenesis
Oriented cell divisions are critical for the formation and maintenance of structured epithelia. Proper mitotic spindle orientation relies on polarised anchoring of force generators to the cell cortex by the evolutionarily conserved Gαi-LGN-NuMA complex. However, the polarity cues that control cortic...
ORGANISM(S): Homo sapiens (Human) 
2022-12-02 | PXD027452 | Pride
Mammary Proteomics Annexin a1 
ProteomicsImmunopeptidomics guided identification of neoantigens in non-small cell lung cancer
Discovery of tumour specific peptides (neoantigens) generating target specific personalised T cell therapies is difficult because of the complex relationship between genetic mutations and neoantigen presentation. Studies predicting neoantigens have a 5% success rate, and direct observations of neoan...
ORGANISM(S): Homo sapiens (Human) 
2026-07-03 | PXD028990 | Pride
Cancer Hla Lung Neoantigen Peptidome 
ProteomicsNon-small cell lung cancer global proteomics
We present data of global proteomes for non-small cell lung cancer for squamous cell and adenocarcinoma, and for normal adjacent tissue.
ORGANISM(S): Homo sapiens (Human) 
2024-12-17 | PXD054390 | Pride
Human lung cancer global proteome 
ProteomicsImmunopeptidomics of ex-vivo tissues to identify T cell vaccine candidates for influenza
We present data comparing an immortal macrophage-like cell lines with ex-vivo infected lung tissues as the presentation models of direct observation of CD4 and CD8 T cell epitopes eluted from the cell surface using mass spectrometry (immunopeptidomics) of presented HLA bound peptides.
ORGANISM(S): Homo sapiens (Human) 
2022-01-13 | PXD022884 | Pride
Hla Influenza Lung Dendritic cell Peptidome 
ProteomicsIdentification of sensitiser modified HLA-peptides presented by keratinocytes
Skin sensitisation following the covalent modification of proteins by low molecular weight chemicals (haptenation) is mediated by cytotoxic T lymphocyte (CTL) recognition of human leukocyte antigen molecules (HLA) presented on the surface of almost all nucleated cells. There are three nonmutually ex...
ORGANISM(S): Homo sapiens (Human) 
2021-01-04 | PXD021373 | Pride
Human Keratinocytes Hla Dncb Peptidome 
Sort   by:  
 Page size