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ProteomicsMulti-omics Dissection of MAPK-driven Senescence Unveils Therapeutic Vulnerabilities in KIAA1549::BRAF-fusion Pediatric Low-Grade Glioma Models
This study investigates molecular mechanisms regulating oncogene-induced senescence (OIS) and senescence-associated secretory phenotype (SASP) in pediatric low-grade gliomas (pLGGs). Using multi-omics analysis of a pilocytic astrocytoma cell line, we identified key OIS effectors and pathways affecte...
ORGANISM(S): Homo sapiens (Human) 
2025-06-30 | PXD060126 | Pride
Senescence-associated secretory phenotype Mapk pathway Multi-omics Oncogene-induced senescence Mapk inhibitor Pediatric low-grade glioma 
ProteomicsMapping the castor bean endosperm proteome revealed a metabolic interaction between plastid, mitochondria, and peroxisomes to optimize seedling growth
The aim of the project was to elucidate the inter-organellar interplay of plastids, mitochondria, and peroxisomes during storage reserve mobilization in the endosperm to supply the growing seedling with nutrients upon germination. Organelles from endosperm of etiolated castor bean seedlings were iso...
ORGANISM(S): Ricinus communis 
2024-01-09 | PXD040932 | Pride
Proteomic study Storage reserve mobilization Inter-organellar interplay Metabolic network Metabolism 
ProteomicsM.abscessus Proteome and Secretome
Members of the Mycobacterium (M.) abscessus complex (MABC) are rapidly growing mycobacteria showing smooth and/or rough colony morphotype. While not as virulent as M. tuberculosis, they can cause soft tissue infection and fatal pulmonary disease, especially in patients with cystic fibrosis. Diagnosi...
ORGANISM(S): Mycobacterium abscessus 
2022-01-19 | PXD010504 | Pride
Lc-ms Non tuberculous mycobacteria Secretome Mycobacterium abscessus Proteomics M.abscessus Cystic fibrosis 
ProteomicsMolecular and epigenetic characterization of the signal transducer CD24 in germ cell tumors
Type II germ cell tumors (GCTs) are with more than 90% the most common neoplasia in young men of age 14 - 45 years. It is generally accepted that GCTs arise from a common precursor lesion, called germ cell neoplasia in situ (GCNIS), eventually developing into seminomas or non-seminomas. The non-sem...
ORGANISM(S): Homo sapiens (Human) 
2022-01-19 | PXD025110 | Pride
Epigenetics Pluripotency Embryonal carcinoma Differentiation Cd24 Germ cell tumors 
ProteomicsIdentification of CD24 interaction partners in urologic tumor cell lines
Being involved in adhesion, migration, and invasion, the highly glycosylated signal transducer CD24 (cluster of differentiation 24) has been implicated to play an essential role during carcinogenesis. Previously, the molecular and (epi)genetic regulation of CD24 has been characterized in testicular ...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD039063 | Pride
Germ cell tumor Cd24 Urothelial carcinoma Renal cell carcinoma Co-immunoprecipitation Prostate cancer 
ProteomicsThe long non-coding RNA HOTAIRM1 promotes tumor aggressiveness and radiotherapy resistance in glioblastoma
Glioblastoma is the most common malignant primary brain tumor. Clinically relevant biomarkers are restricted to isocitrate dehydrogenase (IDH) gene 1 or 2 mutation and O6-methylguanine DNA methyltransferase (MGMT) promoter methylation. Long non-coding RNA (lncRNA) alterations may contribute to gliob...
ORGANISM(S): Homo sapiens (Human) 
2022-01-19 | PXD020141 | Pride
Glioblastoma  hotairm1  long non-coding rna  radiosensitivity 
ProteomicsProteome analysis of HepG2 WT and mitochondrial apolipoprotein MIC26 knockout cells under normo- and hyperglycemic conditions
Increased amounts of the mitochondrial apolipoprotein O /MIC26 were found in diabetic patients along with lipid accumulation in murine liver upon MIC26 expression. MIC26 is a MICOS complex constituent present in the mitochondrial inner membrane. Here, we employed a proteomics analysis approach in W...
ORGANISM(S): Homo sapiens (Human) 
2024-09-13 | PXD047246 | Pride
Apolipoproteins Mic26 Mitochondria Micos complex and fatty acid metabolism 
ProteomicsRole of 4EBP1/2 in the response to glucose deprivation
We investigated the function of the mTORC1 substrates and mRNA translation regulators 4EBP1/2 in the response to glucose deprivation. We uncovered that targeting 4EBP1/2 expression had a direct impact on the survival rates of cells challenged with glucose deprivation. To further define the mechanism...
ORGANISM(S): Homo sapiens (Human) 
2024-03-28 | PXD040931 | Pride
Glucose starvation Stress response 4ebp1/2 Mrna translation Mtorc1 
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