Sort   by:  
 Page size 
ProteomicsUSP28 enables oncogenic transformation of respiratory cells and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3K.
Oncogenic transformation of lung epithelial cells is a multi-step process, frequently starting with the inactivation of tumor suppressors and subsequent activating mutations in proto-oncogenes, such as members of the PI3K or MAPK family. Cells undergoing transformation have to adjust to changes, suc...
ORGANISM(S): Homo sapiens (Human) 
2022-04-08 | PXD032810 | Pride
Braf Buparlisib C-jun Vemurafenib Usp28 Lung cancer Egfr Pik3ca C-myc Hras gefitinib 
ProteomicsEndogenous anti-tumorigenic nitro-fatty acids are a novel type of direct and potent inhibitor of the 26S proteasome
Nitro-fatty acids (NFAs) are endogenous lipid mediators causing a broad spectrum of anti-inflammatory effects by covalent modification of key proteins within inflammatory signaling pathways. Their potential as anti-tumorigenic therapeutics has recently been demonstrated in animal models of solid tum...
ORGANISM(S): Homo sapiens (Human) 
2024-03-26 | PXD035951 | Pride
Cancer 26s proteasome Nitro-fatty acids 
ProteomicsEndogenous anti-tumorigenic nitro-fatty acids are a novel type of direct and potent inhibitor of the 26S proteasome
Nitro-fatty acids (NFAs) are endogenous lipid mediators causing a broad spectrum of anti-inflammatory effects by covalent modification of key proteins within inflammatory signaling pathways. Their potential as anti-tumorigenic therapeutics has recently been demonstrated in animal models of solid tum...
ORGANISM(S): Homo sapiens (Human) 
2024-03-26 | PXD041458 | Pride
Nitroalkylation Caco2 26s proteasome Lc-ms/ms 
UnknownMild hypothermia alone or in combination with anesthetic post-conditioning reduces expression of inflammatory cytokines in the cerebral cortex of pigs after cardiopulmonary resuscitation.
Not available
S-EPMC2875536 | biostudies-literature
ProteomicsHistone Modification Analysis of Oligodendroglioma and Astrocytoma Brain Cancer Samples
WHO classification for tumors of the central nervous system strongly endorses molecular tests for the precise diagnosis of diffuse gliomas. While alterations in the DNA methylation status of gliomas are already well documented and used in specialised clinical centers to distinguish between brain tum...
ORGANISM(S): Homo sapiens (Human) 
2020-01-17 | PXD015151 | Pride
Oligodendroglioma Histone modifications Brain cancer Astrocytoma Histone epi-proteome 
UnknownAssociation of a common TLR-6 polymorphism with coronary artery disease - implications for healthy ageing?
Not available
S-EPMC4028875 | biostudies-literature
ProteomicsCargo and lipid profiling of isolated autophagosomes upon basal autophagy, starvation, and proteasome inhibition
Autophagy is responsible for degradation of an extensive portfolio of cytosolic cargoes that are engulfed in autophagosomes to facilitate their transport to lysosomes. Besides basal autophagy, which constantly degrades cellular material, the pathway is dynamically altered by different conditions, re...
ORGANISM(S): Homo sapiens (Human) 
2022-10-06 | PXD024419 | Pride
Hela Autophagy Autophagosome Label free quantification 
ProteomicsCalcitriol promotes differentiation of glioma stem-like cells and increases their susceptibility to temozolomide
Cancer cells with a stem-like phenotype are commonly described in glioblastoma, the most common primary adult brain cancer, that are thought to be highly tumorigenic. This phenotype comprimes high self renewal capacity and resistance against chemotherapy and radiation therapy, thereby promoting tumo...
ORGANISM(S): Homo sapiens (Human) 
2021-07-19 | PXD026789 | Pride
Calcitriol  vitamin d3  glioblastoma  glioblastoma stem-like cells 
ProteomicsA microprotein encoded by FERMT3 modulates endothelial cell protein catabolism and induces cell cycle arrest and senescence
Background: Endothelial cells express numerous microproteins (miPs) encoded by small open reading frames (smORFs), yet the biological functions of most remain unknown. This study set out to characterize a novel 69 amino acid miP encoded within the FERM domain containing kindlin-3 transcript (miP-FER...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD077152 | Pride
Protein ubiquitination Microprotein Endothelial cell Proteasome Smorf Senescence 
ProteomicsHuman mitochondrial protein import proteomics LFQ
Most mitochondrial proteins are encoded in the nucleus and require mitochondrial import after translation in the cytosol. A number of mutations in the mitochondrial protein import machinery have been shown to lead to human pathologies. However, a lack suitable tools to measure mitochondrial protein ...
ORGANISM(S): Homo sapiens (Human) 
2021-12-18 | PXD024054 | Pride
Meprod Mitochondrial import Lfq Human 
Sort   by:  
 Page size