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ProteomicsVariation in mouse chemical signals is genetically controlled and environmentally modulated
Urine proteomes of the house mouse (Mus musculus musculus, M. m. domesticus, M. m. castaneus).
ORGANISM(S): Mus musculus musculus Mus musculus domesticus Mus musculus castaneus 
2023-07-20 | PXD037086 | Pride
Volatiles House mouse Urine Metabolome Olfactory Lipocalin Chemical communication Wild animals Captivity Proteome 
ProteomicsMlf Mediates Proteotoxic Response via Formation of Cellular Foci for Protein Folding and Degradation
Myeloid leukemia factor 1 (Mlf1) was identified as a proto-oncoprotein that affects hematopoietic differentiation in humans. However, its cellular function remains elusive, spanning roles from cell cycle regulation to modulation of protein aggregate formation and participation in ciliogenesis. Given...
ORGANISM(S): Giardia intestinalis (Giardia lamblia) 
2025-05-13 | PXD050586 | Pride
: myeloid leukemia factor Giardia Protein quality control Ubiquitin-rich bodies Stress response Proteasome 
ProteomicsProteomic insight into the interaction of Paenibacillus larvae with honey bee larvae before capping collected from an American foulbrood outbreak
The samples used in this study originated from colonies of managed European honey bees (A. mellifera) that were at the epicenter of an AFB outbreak in 2020. The colonies were officially examined by the State Veterinary Administration of the Czech Republic. For our analyses, we targeted brood samples...
ORGANISM(S): Paenibacillus Larvae Apis Mellifera 
2022-04-11 | MSV000089235 | MassIVE
ProteomicsPaenibacillus larvae exoproteins of ERIC I-IV genotypes
The following strains of Paenibacillus larvae classified as ERIC I-IV genotypes (pl1-pl4) were used in the study: ERIC I - DSM-7030; ERIC II - DSM-25430; ERIC III - LMG-16252; and ERIC IV - DSM-3615. The 7 biological replicates (a-g) of the exoprotein fractions prepared from each ERIC genotype were ...
ORGANISM(S): Paenibacillus Larvae (ncbitaxon:1464) 
2019-03-27 | MSV000083636 | MassIVE
ProteomicsDDX17 helicase promotes resolution of R-loop-mediated transcription-replication conflicts in human cells
R-loops are three-stranded nucleic acid structures composed of an RNA:DNA hybrid and displaced DNA strand. These structures can halt DNA replication when formed co- transcriptionally in the opposite orientation to replication fork progression. Recent studies have shown that replication forks stalled...
ORGANISM(S): Homo sapiens (Human) 
2022-11-02 | PXD034331 | Pride
Dna replication stress  r-loop  helicase  genomic instability  transcription 
ProteomicsProteome analysis of HEK293 cells stably expressing wild-type and mutated AGAL enzyme
Fabry disease is an X-linked condition caused by variants of the GLA gene that result in the absence or enzymatic deficiency of alpha-galactosidase A (AGAL). This enzyme defect leads to lysosomal storage of globotriaosylceramide (Gb3Cer) in a variety of cell types throughout the body and manifests a...
ORGANISM(S): Homo sapiens (Human) 
2025-11-06 | PXD033936 | Pride
Alpha-galactosidase a Fabry disease 
ProteomicsProteomic analysis of Fam83h deficient and wild type ileum
We generated Fam83h-deficient mice (Fam83hem2(IMPC)Ccpcz, Fam83h-/-) and mice lacking a part of N-terminal CK1-binding domain (Fam83h∆87/∆87). Co-IP with anti-FAM83H antibody has confirmed the FAM83H–CK1 interaction in Fam83hwt/wt samples, which was absent in Fam83h-/- lysates. Additionally, samples...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-08 | PXD064193 | Pride
Fam83h-deficient mice Fam83h 
ProteomicsProteogenomics_of_Dermatophagoides_farinae
Pools of 1,000 individually collected, verified and sex-sorted individuals of Dermatophagoides farinae per biological replicate were used. We ensured that each of the mites included in the analysis was alive, free of contaminants and of a specific size at the time of collection. The separate analyse...
ORGANISM(S): Dermatophagoides Farinae (ncbitaxon:6954) 
2019-05-03 | MSV000083744 | MassIVE
ProteomicsPhosphorylation of TRF2 promotes its interaction with TIN2 and regulates DNA repair at damaged telomeres
Protein phosphatase magnesium-dependent 1 delta (PPM1D) is involved in termination of the cell cycle checkpoint by counteracting activity of the tumour suppressor protein p53. By dephosphorylating various proteins at chromatin, PPM1D contributes to the control of DNA damage response and DNA repair. ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035268 | Pride
Trf2 Dna repair Ppm1d Dna damage response 
ProteomicsMitochondrially targeted tamoxifen alleviates markers of obesity and type 2 diabetes mellitus in mice
Type 2 diabetes mellitus represents a major health problem with increasing prevalence worldwide. Limited efficacy of current therapies have prompted a search for novel therapeutic options. Here we show that treatment of pre-diabetic mice with mitochondrially targeted tamoxifen, a potential anti-canc...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-20 | PXD031710 | Pride
Obesity Mice Mitochodnria Tamoxifen 
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