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ProteomicsProteomics of MSC-derived exosomes upon Plekhm1-KO
Leukemia cells instruct their surrounding bone marrow microenvironment (BMM) rendering it hospitable to leukemia cell survival. Conversely, how cells of the BMM influence leukemia progression is less well understood. Pleckstrin homology domain family M member 1 (PLEKHM1) serves as a hub between fusi...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-16 | PXD027041 | Pride
Exosome Mesenchymal stromal cells Lfq Qexactive hf 
Proteomicsproteomic analysis of leukocytes upon Plekhm1-KO
Leukemia cells instruct their surrounding bone marrow microenvironment (BMM) rendering it hospitable to leukemia cell survival. Conversely, how cells of the BMM influence leukemia progression is less well understood. Pleckstrin homology domain family M member 1 (PLEKHM1) serves as a hub between fusi...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-16 | PXD027044 | Pride
Sps-ms3 Tmt Mesenchymal stromal cells Mouse Orbitrap lumos 
ProteomicsA PROTAC Targets Splicing Factor 3B1
The proteolysis-targeting chimera (PROTAC) is a new technology to degrade a target protein. However, its clinical application is limited currently by lack of chemical binders to target protein. For instance, it is still unknown, whether splicing factor 3B subunit 1 (SF3B1) is targetable by PROTACs. ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-08 | PXD024661 | Pride
Hela Tmtpro Protac Orbitrap lumos 
ProteomicsProteome and SUMOylome of mouse heart tissue after ischemia and reperfusion
Here we provide proteome and SUMOylation patterns of proteins in the heart throughout ischemia and reperfusion. Moreover, we identify SUMO1 and SUMO2 target proteins in vivo
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD021640 | Pride
Mouse Ischemia Proteome Sumo 
ProteomicsProteomics analysis of a new Cas9-targeting PROTAC molecule
Scientists have developed several methods to control the activity of Cas protein in a timely way and hence reduce off-target effects, including anti-CRISPR proteins and small molecule inhibitors. The PROTAC is a new conception of using the natural ubiquitin-proteasome system to degrade the protein o...
ORGANISM(S): Homo sapiens (Human) 
2022-10-18 | PXD022199 | Pride
Crispr-cas9 Qexactive hf Protac Lc-ms/ms 
Proteomicshuman glioma cell-line proteomics upon treatment with different drugs
Increasing evidence suggests that induction of lethal autophagy carries potential significance for the treatment of glioblastoma (GBM). In continuation of our previous work, we investigated if autophagy-inducing compunds can trigger ATG-dependent cell death in human MZ-54 GBM cells and which pathway...
ORGANISM(S): Homo sapiens (Human) 
2021-02-26 | PXD015074 | Pride
Glioma Tmt10 Qexactive hf Human 
ProteomicsLAMTOR1 interactome upon knock out of USP32
Ubiquitination is among the most prevalent post-translational modifications regulating a great number of cellular functions, and defects in such processes contribute to many diseases. Deubiquitinating enzymes (DUBs) are essential to control the precise outcome of ubiquitin signals. The ubiquitin-spe...
ORGANISM(S): Homo sapiens (Human) 
2023-01-16 | PXD024940 | Pride
Q exactive hf Lfq Lamtor1 Ubiquitin Usp32 Lc-ms/ms 
ProteomicsLAMTOR1 interactome upon mutation of USP32
Ubiquitination is among the most prevalent post-translational modifications regulating a great number of cellular functions, and defects in such processes contribute to many diseases. Deubiquitinating enzymes (DUBs) are essential to control the precise outcome of ubiquitin signals. The ubiquitin-spe...
ORGANISM(S): Homo sapiens (Human) 
2023-01-16 | PXD035974 | Pride
Rpe1 Interactome Lamtor1 Usp32 
ProteomicsIP-MS of human YKT6 upon mutation of possible ULK1-phosphorylation sites
Autophagy is a catabolic process during which cytosolic material is enwrapped in a newly formed double membrane structure called the autophagosome, and subsequently targeted for degradation in the lytic compartment of the cell. The fusion of autophagosomes with the lytic compartment is a tightly reg...
ORGANISM(S): Homo sapiens (Human) 
2023-03-02 | PXD038148 | Pride
Human Q exactive hf Hela Ip-ms Ykt6 Lfq 
ProteomicsCoronavirus PLPro interactome AP-MS data
Main proteases and papain-like proteases (PLpro) are essential coronaviral enzymes required for polypeptide processing during viral maturation. PLpro additionally cleave host cellular proteins to evade anti-viral immune responses. Here, we provide biochemical, structural and functional characterizat...
ORGANISM(S): Homo sapiens (Human) 
2020-08-05 | PXD018983 | Pride
Isgylation Ap-ms Sars-cov-2 Plpro 
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