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ProteomicsTMT6-switch - Identification and quantification of S-nitrosylation by cysteine reactive tandem mass tag switch assay
HPAEC lysate treated with GSNO followed by TMT6-switch
ORGANISM(S): Homo sapiens (Human) 
2012-01-16 | PRD000411 | Pride
ProteomicsTMT6plex quantitative proteomics of 293T NME4 KO cell
To identify the role NME4,we knockout NME4 in 293T cells. Followed by protein extraction, trypsin digestion, TMT6 labeled, HPLC fractionation and LC-MS/MS.
ORGANISM(S): Homo sapiens (Human) 
2023-10-13 | PXD036628 | Pride
Human nme4 tmt6 
ProteomicsHuman substantia nigra proteome dataset
Quantitative proteomic analysis of human post-mortem substantia nigra from patients with Parkinson’s disease (n=3) versus controls (n=3) based on sixplex TMT (TMT6) isobaric labeling which allowed protein simultaneous identification and quantification. Samples were digested and pooled after TMT6 lab...
ORGANISM(S): Homo sapiens (Human) 
2014-01-28 | PXD000427 | Pride
Human Post-mortem tissue Parkinson's disease Offgel lc/ms/ms orbitrap Hpp brain Substantia nigra 
ProteomicsTMT-6plex quantitative proteomics reveal an association between the TRX-related pathway and hyperhomocysteinemia-hypertension in children and adolescents
Raw data of TMT6 quantification for children hyperhomocysteinemia-hypertension
ORGANISM(S): Homo Sapiens 
PXD033318 |
ProteomicsQuantitative proteomics analysis of cumulus cells from the young and old mice
Cumulus cells from the young and old mice were subjected to the TMT6 labeling, HP-RP fractionation, and LC-MS/MS analysis. Cumulus cells surrounding 375 oocytes were collected in each of the three biological replicates. Raw files were analyzed using MaxQuant software.
ORGANISM(S): Mus musculus (Mouse) 
2025-08-25 | PXD050687 | Pride
Mouse Lc-ms/ms Tmt Cumulus cells 
ProteomicsA systematic screening pipeline identifies a new regulator of tyrosinated microtubule dynamics
Tubulin detyrosination is a reversible post-translational modification thought to be important for processes including the generation of cell polarity and cell division. The Y/ΔY cycle does not affect the intrinsic properties of microtubules per se, but rather influences the cohort of microtubule-as...
ORGANISM(S): Homo sapiens (Human) 
2022-08-16 | PXD030448 | Pride
Microtubule Detyrosination Tmt6 Human Tyrosination Lc-ms/ms 
ProteomicsProteomic screen reveals Fbw7 as a modulator of the NF-kB pathway
Proteomics on HCT116 cells. 3 samples wild-type, 3 samples Fbw7 KO. Subcellular fractionation to cytoplasmic and nuclear fractions. Proteins were reduced with DTT, alkylated with iodoacetamide, digested with trypsin, and labelled with TMT6-plex: 126,127,128 - wildtype; 129,130,131 - Fbw7 KO. Sample...
ORGANISM(S): Homo sapiens (Human) 
2012-06-29 | PXD000005 | Pride
Lc-msms orbitrap human colon epithelium fbw7 hirief 
ProteomicsAlzheimer stage proteomics study
This project aims to study the pathological role of Extracellular vesicles (EVs) in human brain and the correlation between EVs secretion with whole brain proteome. EVs are extracted from human brain tissue of Alzheimer dementia (AD) patients, VaD patients and age matched healthy controls using PROS...
ORGANISM(S): Homo sapiens (Human) 
2020-05-04 | PXD015578 | Pride
Human Brain 
ProteomicsCharacterisation of the protein cargo of murine plasma microparticles released during experimental cerebral malaria
Cerebral malaria (CM) is a severe complication of a Plasmodium falciparum infection and is still responsible for a high number of deaths and long term disabilities in children in sub-Saharan Africa. The pathogenesis of this syndrome remains incompletely understood but a number of mechanisms and effe...
ORGANISM(S): Mus musculus (Mouse) 
2016-12-13 | PXD003772 | Pride
Qexactive orbitrap Protein cargo Tandem mass tag (tmt) Microparticles Experimental cerebral malaria 
ProteomicsTarget identification for 11q13 amplicon
Proteomic strategy to define therapeutically relevant targets in cell lines that contain the 11q13 amplicon compared to those that do not and to ascertain which genes are amplified at the protein level and, concomitantly, are key drivers for tumor growth and/or maintenance. Furthermore, so called p...
ORGANISM(S): Homo sapiens (Human) 
2015-08-04 | PXD002486 | Pride
Human Lc-msms Head and neck Cell surface protein enrichment Breast 11q13 Liver Oscc Tmt6 quantitation 
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