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ProteomicsIdentification of proximal SUMO-dependent interactors using SUMO-ID
To study the function of SUMOylation and SUMO-SIM interactions for particular substrates poses several challenges. SUMOylation occurs transiently and often in a small percentage of the total copy numbers of a given substrate. Modified proteins can be readily deSUMOylated and SUMO can be recycled and...
ORGANISM(S): Homo sapiens (Human) 
2021-09-21 | PXD021923 | Pride
Human Turbo-id Proximity labeling Sall1 Sumo-id Sumo 
ProteomicsThe ER-embedded UBE2J1/RNF26 ubiquitylation complex in spatio-temporal control of the endolysosomal pathwayThe ER-embedded UBE2J1/RNF26 ubiquitylation complex in spatio-temporal control of the endolysosomal pathway
The endolysosomal system fulfills a wide variety of cellular functions, many of which are modulated through interactions with other organelles. In particular, the ER exerts spatiotemporal constraints on the organization and motility of endosomes and lysosomes. We have recently described the ER trans...
ORGANISM(S): Homo sapiens (Human) 
2021-01-22 | PXD022104 | Pride
Endoplasmic reticulum Endosomes Ubiquitin Rnf26 Egfr Ube2j1 
ProteomicsDeubiquitinating enzymes and the proteasome regulate unique sets of ubiquitin substrates.
The ubiquitin-proteasome axis has been extensively explored at a system-wide level, but the impact of deubiquitinating enzymes (DUBs) on the ubiquitinome remains largely unknown. Using UbiSite technology and inhibitors, we have compared the contributions of the proteasome and DUBs on the ubiquitinom...
ORGANISM(S): Homo sapiens (Human) 
2022-05-23 | PXD027328 | Pride
Human Ubisite Pr619 Tak243 U2os Ubiquitin Mg132 
ProteomicsDeubiquitinating enzymes and the proteasome regulate unique sets of ubiquitin substrates.
The ubiquitin-proteasome axis has been extensively explored at a system-wide level, but the impact of deubiquitinating enzymes (DUBs) on the ubiquitinome remains largely unknown. Using UbiSite technology and inhibitors, we have compared the contributions of the proteasome and DUBs on the ubiquitinom...
ORGANISM(S): Homo sapiens (Human) 
2022-05-23 | PXD027330 | Pride
Human Pr619 Tak243 U2os His10-ub Ubiquitin Mg132 
MetabolomicsA metabolic dependency of EBV can be targeted to hinder B cell transformation

Following infection of B cells, Epstein Barr virus (EBV) engages host pathways that mediate cell proliferation and transformation, contributing to the propensity of the virus to drive immune dysregulation and lymphomagenesis. We found that the EBV protein EBNA2 initiates NAD de novo bios...

2024-04-29 | MTBLS2243 | MetaboLights
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