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ProteomicsLysine Ubiquitination - Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling
Identification of ubiquitin remnant peptides using a diglycyl-lysyl monoclonal antibody for immunoprecipitation
ORGANISM(S): Homo sapiens (Human) 
2010-08-11 | PRD000220 | Pride
ProteomicsUbiquitin remnant profiling for identification of the ubiquitylation sites in mysterin
Ubiquitin remnants obtained from the cells expressing variants of ubiquitin ligase mysterin were analyzed by mass spectrometry to identify the ubiquitylation sites in mysterin. HN indicates the RING finger mutant (H4014N). RZ indicates the RZ finger mutant (H4509A). A1A2 indicates the ATPase mutant ...
ORGANISM(S): Homo sapiens (Human) 
2026-10-02 | PXD055333 | Pride
Lc-msms Ubiquitinome Human cells 
ProteomicsMus musculus primary CD4+ T cell di-glycine remnant and whole cell proteomics
It is known that ubiquitination is important for T cell receptor (TCR) signaling during T cell activation but the breadth of ubiquitination events triggered during TCR signaling is not completely understood. This dataset utilizes di-glycine remnant profiling combined with mass spectrometry to identi...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-09 | PXD012831 | Pride
Mus musculus primary cd4+ t cell di-glycine remnant and whole cell proteomics 
ProteomicsGlobal ubiquitinome profiling identify Nedd4 as aregulator of Profilin 1 and actin remodeling in neural crest cells
We utilized quantitative analyses of the proteome, transcriptome, and ubiquitinome to study how ubiquitination and NEDD4 control neural crest cell survival and stem-cell-like properties. We report 276 novel NEDD4 targets in neural crest cells and show that loss of NEDD4 leads to a striking global r...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-08 | PXD024103 | Pride
Nedd4 Ubiquitin remnant enrichment Mouse Neural crest 
ProteomicsProteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function
VCP is an evolutionary conserved ubiquitin-dependent ATPase that mediates the degradation of proteins through the ubiquitin-proteasome pathway. Despite the central role of VCP in the regulation of protein homeostasis, identity and nature of its cellular substrates remain poorly defined. Here, we com...
ORGANISM(S): Homo sapiens (Human) 
2018-02-09 | PXD003936 | Pride
Ubiquitin-proteasome system Ubiquitin remnant profiling Quantitative mass spectrometry Protein homeostasis Vcp 
UnknownGlobal analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling.
Not available
S-EPMC2946519 | biostudies-literature
ProteomicsMaxQuant.Live enables enhanced selectivity and identification of peptides modified by endogenous SUMO and ubiquitin
Small ubiquitin-like modifiers (SUMOs) and ubiquitin are frequent post-translational modifications of proteins that play pivotal roles in all cellular processes. We previously reported mass spectrometry-based proteomics methods that enable profiling of lysines modified by endogenous SUMO or ubiquiti...
ORGANISM(S): Homo sapiens (Human) 
2021-02-05 | PXD022367 | Pride
Peptide mass filtering Sumo Mql Ubiquitin Maxquant.live Precursor untargeting 
ProteomicsThe RNA-binding ubiquitin ligase MKRN1 acts as a sensor for ribosome-associated quality control of poly(A)-translation
Human cells have evolved multiple quality control mechanisms to ensure protein homeostasis by detecting aberrant mRNAs and protein products which are condemned for rapid decay. Translating ribosomes that run into poly(A) tails are terminally stalled, followed by ribosome recycling and rapid decay of...
ORGANISM(S): Homo sapiens (Human) 
2019-08-19 | PXD011772 | Pride
Ubiquitylation Rna binding Ubiquitin remnant profiling Poly(a) Mkrn1 Iclip Ribosome-associated quality control 
ProteomicsUbiquitin remnant motif profiling (Ubiquitomics) in VACV infected HeLa cells
HeLa cells were pretreated with MG132, inoculated with VACV-Cop at an MOI of 3 for 1 h, and posttreated with MG132 again. Cells were lysed and extracted proteins were digested to peptides using trypsin, and desalted peptides were subjected to automated diGly enrichment using the PTMScan ubiquitin re...
ORGANISM(S): Vaccinia Virus Copenhagen (ncbitaxon:10249) Homo Sapiens (ncbitaxon:9606) 
2024-02-05 | MSV000094020 | MassIVE
ProteomicsdiGly ubiquitin remnant profiling upon TFEB overexpression
We performed proteomic analysis of di-Gly peptides to identify which proteins are ubiquitinated in cells overexpressing TFEB compared to non-expressing cells.
ORGANISM(S): Homo sapiens (Human) 
2025-11-18 | PXD065497 | Pride
Ubiquitin Digly Tfeb Hela 
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