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ProteomicsVinculin-network mediated cytoskeletal remodeling regulates contractile function in the aging heart - Rat Data
The human heart is capable of functioning for decades despite minimal cell turnover or regeneration, suggesting that molecular alterations help sustain heart function with age. However, identification of compensatory remodeling events in the aging heart remains elusive. Here we present the proteomes...
ORGANISM(S): Rattus norvegicus (Rat) 
2016-04-15 | PXD001839 | Pride
Proteomics Rattus norvegicus Mass spectrometry Cytoskeleton Macacca mulatta Biomarkers Stiffness Drosophila melanogaster 
ProteomicsVinculin-network mediated cytoskeletal remodeling regulates contractile function in the aging heart - Monkey data
The human heart is capable of functioning for decades despite minimal cell turnover or regeneration, suggesting that molecular alterations help sustain heart function with age. However, identification of compensatory remodeling events in the aging heart remains elusive. Here we present the proteomes...
ORGANISM(S): Macaca mulatta (Rhesus macaque) 
2018-10-19 | PXD001842 | Pride
Proteomics Rattus norvegicus Mass spectrometry Cytoskeleton Macacca mulatta Biomarkers Stiffness Drosophila melanogaster 
ProteomicsPASS00724 - Raw DIA files and libraries used in the manuscript "Identification of a Set of Conserved Eukaryotic Internal Retention Time Standards for Data-Independent Acquisition Mass Spectrometry"
Data independent acquisition files and corresponding library files used to demonstrate the value of a set of conserved, commonly occurring peptide sequences to align chromatographic retention time between spectral libraries and DIA files.
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2018-08-23 | MSV000082842 | MassIVE
ProteomicsA novel phosphorylation site at Ser130 adjacent to the pseudosubstrate domain regulates protein kinase C-δ activity
Protein kinase C over-expressed into rat neonatal myocytes were lysed in 8M Urea, 0.1% SDS and trypsin digested. Peptides were fractionated by SPE-SCX and enriched by TiO2. Phosphopeptides were analyzed by LC/MS on a Thermo LTQ Elite Orbitrap. Raw files were searched using Sorcerer-Sequest and pos...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-10-24 | PXD002536 | Pride
Phosphorylation Pkc Protein kinase c 
ProteomicsHigh Field Asymmetric Waveform Ion Mobility Spectrometry- Mass Spectrometry to Enhance Cardiac Muscle Proteome Coverage
Heart tissue sample preparation for mass spectrometry (MS) analysis that includes pre-fractionation reduces the cellular protein dynamic range and increases the relative abundance of non-sarcomeric proteins. We previously described “IN-Sequence” (IN-Seq) where heart tissue lysate is sequentially par...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD039174 | Pride
Faims Dia-ms Cardiac In-seq 
ProteomicsHuman HFpEF Myocardial Proteomics
Background: Heart failure with preserved ejection fraction (HFpEF) constitutes more than half of all heart failure but has few effective therapies. Recent human myocardial transcriptomics and metabolomics have revealed major differences between HFpEF, HF with reduced EF (HFrEF), and controls. How th...
ORGANISM(S): Homo sapiens (Human) 
2024-03-05 | PXD045677 | Pride
Proteomics Myocardium Obesity Molecular medicine Heart disease Human 
ProteomicsMyocardial Proteome in Human Heart Failure with Preserved Ejection Fraction
Background: Heart failure with preserved ejection fraction (HFpEF) constitutes more than half of all heart failure but has few effective therapies. Recent human myocardial transcriptomics and metabolomics have revealed major differences between HFpEF, HF with reduced EF (HFrEF), and controls. How th...
ORGANISM(S): Homo sapiens (Human) 
2025-04-11 | PXD060431 | Pride
Oxidative phosphorylation Metabolism Fatty acids Proteomics Obesity Myocardium Molecular medicine : heart failure 
ProteomicsChanges in S-nitroslyaion in a mouse model of preeclampsia
SNO modifications were quantified in placentas (n=5, each group) from control, -/-GSNOR, +ascorbate and -/-GSNOR+ascorbate.
ORGANISM(S): Mus musculus (Mouse) 
2022-05-19 | PXD012706 | Pride
S-nitrosylation Preeclampsia Biotin switch Placenta 
ProteomicsHs_Albuminome_Serum
Albuminome from human serum
ORGANISM(S): Homo Sapiens (human) 
2013-12-31 | PAe005187 | PeptideAtlas
ProteomicsHs_Albuminome_CSF
Albuminome from human CSF
ORGANISM(S): Homo Sapiens (human) 
2013-12-31 | PAe005108 | PeptideAtlas
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