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ProteomicsChromokinesin KIF4A teams up with STMN1 to regulate abscission in a SUMO-dependent manner
Cell division ends when two daughter cells physically separate via abscission, the cleavage of the intercellular bridge. It is currently less clear how the anti-parallel microtubule bundles bridging daughter cells are severed. Here, we provide evidence for a novel abscission mechanism. We found that...
ORGANISM(S): Homo sapiens (Human) 
2020-07-14 | PXD007055 | Pride
Cytokinesis Abscission Kif4a Mitosis Human Stmn1 Sumo Lc-ms/ms 
ProteomicsIdentification of proximal SUMO-dependent interactors using SUMO-ID
To study the function of SUMOylation and SUMO-SIM interactions for particular substrates poses several challenges. SUMOylation occurs transiently and often in a small percentage of the total copy numbers of a given substrate. Modified proteins can be readily deSUMOylated and SUMO can be recycled and...
ORGANISM(S): Homo sapiens (Human) 
2021-09-21 | PXD021923 | Pride
Human Turbo-id Proximity labeling Sall1 Sumo-id Sumo 
ProteomicsZinc finger protein ZNF384 is an adaptor of KU to DNA during classical non-homologous end-joining
DNA double-strand breaks (DSBs) are among the most deleterious types of DNA damages as they can lead to mutations and chromosomal rearrangements, which underlie cancer development and progression. Non-homologous end-joining (NHEJ) is the dominant pathway for the repair of DSBs in human cells, which ...
ORGANISM(S): Homo sapiens (Human) 
2021-11-15 | PXD020417 | Pride
Non homologous end joining  double strand break repair 
ProteomicsDeubiquitinating enzymes and the proteasome regulate unique sets of ubiquitin substrates.
The ubiquitin-proteasome axis has been extensively explored at a system-wide level, but the impact of deubiquitinating enzymes (DUBs) on the ubiquitinome remains largely unknown. Using UbiSite technology and inhibitors, we have compared the contributions of the proteasome and DUBs on the ubiquitinom...
ORGANISM(S): Homo sapiens (Human) 
2022-05-23 | PXD027330 | Pride
Human Pr619 Tak243 U2os His10-ub Ubiquitin Mg132 
ProteomicsDeubiquitinating enzymes and the proteasome regulate unique sets of ubiquitin substrates.
The ubiquitin-proteasome axis has been extensively explored at a system-wide level, but the impact of deubiquitinating enzymes (DUBs) on the ubiquitinome remains largely unknown. Using UbiSite technology and inhibitors, we have compared the contributions of the proteasome and DUBs on the ubiquitinom...
ORGANISM(S): Homo sapiens (Human) 
2022-05-23 | PXD027328 | Pride
Human Ubisite Pr619 Tak243 U2os Ubiquitin Mg132 
ProteomicsSplicing factors control triple-negative breast cancer cell mitosis through SUN2 interaction and sororin intron retention
Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited therapeutic opportunities. Recently, splicing factors have gained attention as potential targets for cancer treatment. We performed an RNAi screen targeting 244 individual splicing factors to systematically ...
ORGANISM(S): Homo sapiens (Human) 
2021-03-07 | PXD013968 | Pride
Splicing Triple-negative breast cancer 
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