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MetabolomicsGlobal Analyses of Selective Insulin Resistance in Hepatocytes due to Palmitate Lipotoxicity
Obesity is tightly linked to hepatic steatosis and insulin resistance. One feature of this association is the paradox of selective insulin resistance: insulin fails to suppress hepatic gluconeogenesis but activates lipid synthesis in the liver. How lipid accumulation interferes selectively with some...
2018-04-26 | MTBLS582 | MetaboLights
ProteomicsThe proteome and transcriptome of the infectious metacyclic form of Trypanosoma brucei define quiescent cells primed for mammalian invasion
The infectious metacyclic forms of Trypanosoma brucei result from a complex development in the tsetse fly vThe infectious metacyclic forms of Trypanosoma brucei result from a complex development in the tsetse fly vector. When they infect mammals, they cause African sleeping sickness in humans. Due t...
ORGANISM(S): Trypanosoma brucei 
2017-07-31 | PXD006197 | Pride
Trypanosoma brucei Transcriptome Proteome Metacyclics 
ProteomicsProteomic and Phosphoproteomic Analyses of Yeast Reveal the Global Cellular Response to Sphingolipid Depletion
Sphingolipids are essential components of eukaryotic cells with important functions in membrane biology and cellular signaling. Their levels are tightly controlled and coordinated with the abundance of other membrane lipids. How sphingolipid homeostasis is achieved is not yet well understood. Studie...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2016-12-23 | PXD003854 | Pride
Sphingolipid depletion Qexactive hf Phosphoproteomics Yeast 
ProteomicsSystematic genome perturbation reveals coordination of lipid droplets and metabolic gene regulation
Lipid droplets (LDs) store lipids for metabolic eneergy and are central to cellular lipid homeostasis. The mechanisms coordinating lipid storage in LDs with cellular metabolism are unclear but relevant to obesity-related diseases. Here we utilized genome-wide screening to identify genes that modulat...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD012640 | Pride
Metabolism Chrebp Mlx Mondoa Mondob Transcription facot Mlxipl Lipid droplets Glucose Mlxip 
ProteomicsGlobal Analyses of Selective Insulin Resitance in Hepatocytes due to Palmitate Lipotoxicity
Obesity is tightly linked to hepatic steatosis and insulin resistance. One feature of this association is the paradox of selective insulin resistance: insulin fails to suppress hepatic gluconeogenesis but activates lipid synthesis in the liver. How lipid accumulation interferes selectively with some...
ORGANISM(S): Homo sapiens (Human) 
2018-02-14 | PXD006395 | Pride
Insulin resistance Lipotoxicity Phosphoproteomics Hepatic steatosis 
ProteomicseNOS interactors in human cells
Endothelial nitric oxide synthase (eNOS) catalyzes the conversion of L-arginine and molecular oxygen into L-citrulline and nitric oxide (NO), a gaseous second messenger that influences cardiovascular physiology and disease. Several mechanisms regulate eNOS activity and function, including phosphoryl...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD002598 | Pride
Enos Stromal cell-derived factor 2 
ProteomicsPLD3 and PLD4 synthesize lysosomal S,S-BMP
LD3 knock out cells were generated in HEK293T and HMC3 cells. Proteomics was done to test if they have any significant changes in the abundance of proteins that metabolize sugar lipids like gangliosides.
ORGANISM(S): Homo sapiens (Human) 
2024-10-22 | PXD046505 | Pride
Pld3 lysosomes Microglia 
ProteomicsHepatocyte Deletion of Triglyceride-Synthesis Enzyme DGAT2 Reduces Steatosis without Increasing Inflammation or Fibrosis
Non-alcoholic fatty liver disease (NAFLD) is characterized by excess lipid accumulation in hepatocytes and reprepresents a huge public health problem owing to its propensity to progress to non-alcoholic steatohepatitis (NASH), fibrosis, and liver failure. The lipids stored in hepatic steatosis are p...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD013423 | Pride
Triacylglycerol Liver Diacylglycerol Nonalcoholic fatty liver disease Steatohepatitis Dietary lipids 
ProteomicsRab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells
Rab GTPases recruit peripheral membrane proteins and can define organelle identity. Rab18 localizes to the ER but also to the surfaces of lipid droplets (LDs), where it has been implicated in effector protein recruitment and in defining LD identity. Here, we studied Rab18 localization and function i...
ORGANISM(S): Homo sapiens (Human) 
2018-06-06 | PXD009683 | Pride
Triacylglycerol Lipid droplet Endoplasmic reticulum Rab18 Neutral lipid storage Rabgtpase 
ProteomicsIdentification of molecular machinery mediating ER to lipid droplet protein targeting
Lipid droplets (LDs) are organelles that store lipids and contain important metabolic proteins at their surfaces. The pathway for membrane-embedded hydrophobic proteins to reach the LD surface from the ER is largely unknown. Here, we find that many proteins, including key lipid synthesis and degrada...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-06-27 | PXD027283 | Pride
Endoplasmic reticulum Protein trafficking Membrane fusion Protein targeting Lipid droplet 
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