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ProteomicsHuman Serum Immunoglobulin N-Glycosylation using nLC-MS/MS
Here we employ a nLC-MS/MS method to separate small amounts of purified immunoglobulins to characterize the N-glycan reportoire and site occupancy of bulk serum antibodies. Using this method, we have established, for the first time within individual donors, the N-linked glycan repotoire for bulk IgG...
ORGANISM(S): Homo sapiens (Human) 
2019-01-24 | PXD010911 | Pride
Human Igm Serum N-glycosylation Iga2 Iga1 Glycopeptides Igg1 Igg4 Immunoglobulins 
ProteomicsO-fucosylated glycoproteins of Toxoplasma gondii
The fucose-binding Aleuria aurantia lectin (AAL) labels punctiform structures in proximity to the nuclei of Toxoplasma gondii tachyzoites. We have utilized AAL-lectin affinity purification in conjunction with LC MS/MS to identify a set of proteins modified with fucose on serines and threonines
ORGANISM(S): Toxoplasma gondii 
2016-10-11 | PXD004426 | Pride
Lc ms/ms Aal Affinity purification Fucose Nucleus Toxoplasma gondii Lectin 
ProteomicsIdentification of In Vivo HLA-DR-Presented Self-Peptides (T Cell Epitopes) in Synovial Tissue, Synovial Fluid and Peripheral Blood in Patients with Rheumatoid Arthritis or Lyme Arthritis
HLA-DR molecules are highly expressed in synovial tissue (ST), the target of the immune response in chronic inflammatory arthritides, including in rheumatoid arthritis (RA) and Lyme arthritis (LA). In the current study, we identified HLA-DR-presented self-peptides (T cell epitopes) in ST, synovial f...
ORGANISM(S): Homo sapiens (Human) 
2016-10-13 | PXD003051 | Pride
Synovial tissue Synovial fluid Human Peripheral blood Lc-ms/ms 
ProteomicsCD209L/L-SIGN N-Glycosylation and N-Glycosylation Site Occupancy
CD209L is a membrane glycoprotein with known glycan-binding properties and it also contains 2 N-glycosylation sequons at sites N92 and N361. Treatment with PNGase F in the presence of H218O, which removes N-linked glycans and isotopically labels the formerly-glycosylated site, confirmed that both un...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021309 | Pride
Human cd209l Dc-sign N-glycosylation 
ProteomicsN-Glycosylation of the Epidermal Growth Factor Receptor (EGFR) Derived from Human Oral Squamous Carcinoma Cells with beta-Catenin/CREB-Binding Protein (CBP) Inhibition
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy in the world; oral squamous cell carcinomas (OSCC) account for the majority of HNSCC cases. A major driver of OSCC is the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase (RTK) with 12 N-glycosylatio...
ORGANISM(S): Homo sapiens (Human) 
2020-03-26 | PXD017060 | Pride
Human Beta-catenin/cbp inhibition Head and neck cancer Glycoproteomics Hsc-3 Glycopeptide Oral squamous cell carcinoma Oscc Egfr Lc-ms/ms Epidermal growth factor receptor Creb-binding protein Cal27 
MetabolomicsFeatures of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study
Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficit...
2024-01-12 | MTBLS850 | MetaboLights
MetabolomicsThe enduring effects of early-life HFHS exposure and microbiota-targeted interventions on blood metabolome in adult female and male mice

Blood metabolomics of 12-week-old female and male C57BL/6J mice that were exposed to either a control or an unhealthy high-fat/high-sugar (HFHS) diet during early-life, or early-life HFHS diet supplemented with a microbiota-targeted intervention (either a prebiotic combination (fructo-oligosaccha...

2026-01-27 | MTBLS12714 | MetaboLights
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