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ProteomicsFunctional characterisation of tumour suppressor PDCD4 reveals a previously undisclosed role in the control of cell adhesion
PDCD4 is a multifunctional RNA binding protein which has tumour suppressor function. To more fully understand how dysregulation of this protein contributes to carcinogenesis we have carried out a comprehensive analysis of the role of PDCD4 in RNA metabolism in untransformed epithelial cells. We show...
ORGANISM(S): Homo sapiens (Human) 
2024-07-31 | PXD054188 | Pride
Rna-binding Pdcd4 Nucleus Cell adhesion Translation control 
ProteomicseIF5A-dependent feedback inhibition from mRNA translation elongation to initiation induces apoptosis in tumour cells
Cancer progression is associated with disruption in protein synthesis, and novel therapies are being developed to target specific aspects of this process. Traditionally, these treatments have concentrated on the initiation phase of mRNA translation. However, recent discoveries indicate that issues i...
ORGANISM(S): Homo sapiens (Human) 
2025-11-05 | PXD051303 | Pride
Eef2 Elongation Gc7 Dhps Mrna translation control Protein synthesis Isrib Dohh Initiation Hypusination Eif2 Eif5a 
UnknownTocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC8084355 | biostudies-literature
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