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UnknownThe Temporal Lobe Club: Newer Approaches to Treat Temporal Lobe Epilepsy.
Not available
S-EPMC10846515 | biostudies-literature
UnknownPhase I pharmacokinetic and pharmacodynamic study of pazopanib in children with soft tissue sarcoma and other refractory solid tumors: a children's oncology group phase I consortium report.
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S-EPMC3739862 | biostudies-literature
UnknownTotal Synthesis and Structural Reassignment of Laingolide A.
Not available
S-EPMC8145716 | biostudies-literature
ProteomicsOncogenic and microenvironmental signals drive cell type-specific apoptosis resistance in juvenile myelomonocytic leukemia
Juvenile myelomonocytic leukemia (JMML) is caused by constitutively activated RAS signalling and is characterized by increased proliferation and predominant myelomonocytic differentiation of hematopoietic cells. Using Mx-Cre;PTPN11D61Y mice, which reflect human JMML, we show that RAS pathway activat...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD055845 | Pride
Ptpn11 Bcl2 Jmml Apoptosis Bcl-xl Juvenile monocytic leukemia Mcl-1 Extrinsic and intrinsic shp2 signalling Shp2 
ProteomicsIntact extracellular vesicle cross-linking on vesicles derived from MDA-MB-231 and LM2 cells
The development of any pharmaceutical requires characterization of the compound, usually be several techniques. Therefore, characterizing the protein content and biochemical state of EVs is of great importance for their useif they are to be used as biopharmaceuticals. Structural characterization of ...
ORGANISM(S): Homo sapiens (Human) 
2022-11-08 | PXD029591 | Pride
Tnbc Evs Xl-ms Structural proteomics Cx-ms 
TranscriptomicsLactic acidosis triggers starvation response with distinct metabolic profiles
[1] Lactic acidosis time course: MCF7 cells were exposed to lactic acidosis for different length of time. We used microarrays to examine the genomic programs of cells incubated under lactic acidosis for different length of time [2] Metabolic profiling: MCF7 cells were exposed to control condition, ...
ORGANISM(S): Homo sapiens 
2010-09-27 | E-GEOD-19123 | biostudies-arrayexpress
ProteomicsCharacterization of the HLA class I Ligandome from Extracellular vesicles
Extracellular vesicles have shown promise in the field of anti-tumor vaccines. EVs are antigen-presenting entities capable of eliciting potent T-cell responses and have therefore being explored as cell-free based peptide vaccine vectors. However, whether the EV ligandome sufficiently resembles the c...
ORGANISM(S): Homo sapiens (Human) 
2021-07-05 | PXD021177 | Pride
Ev vaccines Extracellular vesicles Immunopeptidomics Ligandome Hla-i 
ProteomicsAn integral atlas of hormone peptides of human EECs and their dedicated proteases
Enteroendocrine cells (EECs) secrete hormones in response to ingested nutrients to control physiological processes such as appetite and insulin release. EEC hormones are synthesized as large pre-proteins that undergo proteolytic processing through peptidases to generate bioactive peptides. Due to th...
ORGANISM(S): Homo sapiens (Human) 
2022-11-26 | PXD033369 | Pride
Peptidomics Lc-msms Proteolytic processing Hormones Enteroendocrine cells 
ProteomicsCardiac progenitor cell-derived extracellular vesicles promote angiogenesis through associated- and co-isolated proteins including PAPP-A
Stem- and progenitor cell transplantation therapy holds great promise for regenerating damaged heart tissue. Several lines of evidence suggest that its efficacy is mainly caused by secreted extracellular vesicles (EVs). EVs are small, cell-derived lipid bilayer enclosed particles that play a role in...
ORGANISM(S): Homo sapiens (Human) 
2023-07-13 | PXD030779 | Pride
Proteomics Evs Angiogenesis Human Cardioprotection Phosphoproteomics Orbitrap exploris 
ProteomicsProteome and (ox)PTP profile analysis of diabetic NOD mouse under single (anti-CD3) or combined (anti-CD3 + IL1RA) treatment
Type 1 diabetes (T1D) results from autoimmune destruction of β cells in the pancreas. Protein tyrosine phosphatases (PTPs) are candidate genes for T1D and play a key role in autoimmune disease development and β-cell function. Here, we assessed the global protein and individual PTP profile in the pan...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-10 | PXD025394 | Pride
Pancreas Mus musculus Oxptp Hf Diabetes Treatment 
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