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ProteomicsQuantitative proteome analysis reveals changes of membrane proteins in Sedum plumbizincicola under cadmium stress
Sedum plumbizincicola is an herbaceous species tolerant of excessive cadmium accumulation in above-ground tissues. The implications of membrane proteins, especially integrative membrane proteins such as transporters, in Cd detoxification in plants have received attention in recent years, but a compr...
ORGANISM(S): Sedum plumbizincicola 
2021-12-30 | PXD025302 | Pride
Cadmium stress Tmt labeling Membrane proteome Sedum plumbizincicola 
ProteomicsAcute proteome responses to de novo sphingolipid synthesis inhibition suggest cancer combination therapies
Sphingolipids are essential structural and signaling lipids that support membrane integrity and govern cell fate decisions. Whereas the consequences of chronic sphingolipid inhibition have been extensively explored, the immediate cellular responses to reduced sphingolipid levels remain poorly define...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD079016 | Pride
Cancer Myriocin Proteome De novo sphingolipid synthesis 
ProteomicsBipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission
AKAP11 deficiency is associated with autophagy-regulated PKA and neuronal activity in mouse brains. We hypothesized that the differentially expressed proteins (DEPs) and phospho-proteins (pDEPs) in AKAP11 conditional KO mice and human iPSC-induced neurons (iNs) could be identified as potential AKAP1...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-12-08 | PXD067156 | Pride
Mouse models Synaptic transmission Er-resident autophagy-related proteins vapa/b Bipolar disorder (bd) Protein kinase a (pka) Pka-ri. Electrophysiology Akap11 Multi-omics Cell biology Schizophrenia (scz) Human induced neurons Gsk3a/b Sphkap 
ProteomicsCharacterize proteome-wide changes in protein abundance and ubiquitination during glucose starvation in wild-type and HOIL-1mut AC16 cardiomyocytesCharacterize proteome-wide changes in protein abundance and ubiquitination during glucose starvation in wild-type and HOIL-1mut AC16 cardiomyocytes
The cells expressing a truncated form of the E3 ubiquitin ligase HOIL-1 are hypersensitive to lethal metabolic stress. We hypothesize that alterations in ubiquitination or abundance of key substrates constitutes a mechanistic underpinning of this phenotype.
ORGANISM(S): Homo sapiens (Human) 
2026-03-13 | PXD046661 | Pride
Tmtpro Hoil-1 Ubiquitination 
OtherJUMP: a tag-based database search tool for peptide identification with high sensitivity and accuracy.
Data from authors [[http://stjuderesearch.org/site/lab/peng web site]]. Experiment: dataset3, file: pl08.mzXML. Published as part of Mol Cell Proteomics. 2014 Sep 8 . From the Abstract: {{i}} ... Here we present JUMP, a new hybrid database search program that generates amino acid tags and ranks pep...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32320003491 | GPMDB
OtherRefined phosphopeptide enrichment by phosphate additive and the analysis of human brain phosphoproteome.
Data from ProteomeXchange, PXD ID: PXD001180. File: tio2_250ug.mzml. Published as part of Proteomics. 2015 Jan;15(2-3):500-7 . From the Abstract: {{i}} Here, we report a pilot investigation of AD phosphoproteome by titanium dioxide enrichment coupled with high resolution LC-MS/MS. During the optimi...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM11210034774 | GPMDB
Resource Reanalysis 
TranscriptomicsType 1 interferons induce changes in core metabolism that are critical for immune function
Type 1 interferons (IFNs) induce complex responses that can be beneficial or deleterious, depending on context. Greater understanding of the mechanisms of action of these cytokines could allow new therapeutic approaches. We found that type 1 IFNs induced changes in cellular metabolism that were cr...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-81889 | biostudies-arrayexpress
ProteomicsHs_Brain_Phospho
Human brain phosphoproteome analyzed by refined phosphopeptide enrichment
ORGANISM(S): Homo Sapiens (human) 
2015-12-31 | PAe005247 | PeptideAtlas
ProteomicsJUMPg: an Integrative Proteogenomics Pipeline Identifying Unannotated Proteins in Human Brain and Cancer Cells
Proteogenomics is an emerging approach to improve gene annotation and interpretation of proteomics data. Here we present JUMPg, an integrative proteogenomics pipeline including customized database construction, tag-based database search, peptide-spectrum match filtering, and data visualization. JUMP...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-16 | MSV000080641 | MassIVE
TranscriptomicsCritical role for the DNA receptor AIM2 in stem-cell proliferation and cancer
Colorectal cancer is a leading cause of cancer-related deaths. Mutations in the innate immune receptor AIM2 are frequently identified in patients with colorectal cancer, but how AIM2 modulates colonic tumorigenesis is unknown. Here, we found that Aim2-deficient mice were hypersusceptible to colonic ...
ORGANISM(S): Mus musculus 
2015-07-15 | E-GEOD-69436 | biostudies-arrayexpress
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