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ProteomicsO-GlcNAcylation of RIPK1 Rescues Red Blood Cells from Necroptosis
Necroptosis is a type of cell death with excessive inflammation and organ damage in various human diseases. Although abnormal necroptosis is common in patients with neurodegenerative, cardiovascular, and infectious diseases, the mechanisms by which O-GlcNAcylation contributes to the regulation of ne...
ORGANISM(S): Homo sapiens (Human) 
2023-06-06 | PXD042579 | Pride
Necroptosis O-glcnac Ripk1 
ProteomicsStriatal proteomics offers clues on the inattention in early adult THRSP-overexpressing mice: Involvement of Snap25 gene
Attention-deficit/hyperactivity disorder, or ADHD, is a neurodevelopmental disorder characterized by inattention, hyperactivity, and impulsivity. Despite its high prevalence, the underlying molecular mechanisms of ADHD remain poorly understood. Recent studies have proposed that changes in the expres...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-22 | PXD051619 | Pride
Animal model Thrsp-oe mice Snare complex Snap25 Thyroid hormone-response protein Adult adhd 
ProteomicsUnveiling Diagnostic Biomarkers in Autism: Comparative Proteome Analysis of CNTNAP2 Knockout Mice and Human ASD Patients
This study identifies conserved protein biomarkers for Autism Spectrum Disorder (ASD) using a cross-species proteomic approach. Proteomic analyses were conducted on serum and brain samples from CNTNAP2 knockout (KO) mice and human ASD patient serum. A total of 132 conserved proteins were identified,...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD060810 | Pride
Machine learning Mass spectrometry Cntnap2 knockout mouse Cross-species comparison Autism spectrum disorder (asd) Proteomics Biomarkers 
ProteomicsLateral interactions between B7-H3 and CD147 are essential for stemness in breast cancer: a novel insight from proximal proteome analysis
Oncogenic cell-surface membrane proteins contribute to the phenotypic and functional characteristics of cancer stem cells (CSCs). We quantitatively analyzed cell-surface membrane proteins that are in close proximity to CD147 in CSCs using proximity-labeling proteomic approach. Moreover, we compared ...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD036909 | Pride
Proximal proteome analysis Breast cancer Cancer stem cells Drug resistance Cd276 Lipid raft Protein-protein interaction Cd147 
ProteomicsCD99-mediated immunological synapse formation potentiates CAR-T cell function
Cross-talks between actin and microtubules underly various cellular processes. Using immune synapse model and via cytoskeleton dynamics analyses, here, we demonstrate that CD99 is critical for the actin and microtubule cross-talks and the coordinated reorganization, mediating their physical linkage ...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-18 | PXD039955 | Pride
Immunology Cd99 
Proteomics2E7 Antigen Identification Using PhAbomics Technology
Antibody–drug conjugates (ADCs) require antibodies with both high specificity and efficient internalization—features often overlooked by conventional discovery pipelines that rely on preselected antigens and recombinant proteins. Here, we present an integrated phenotypic platform that combines targe...
ORGANISM(S): Homo sapiens (Human) 
2025-11-20 | PXD065365 | Pride
Antibody Antigen Cell-based antibody panning 
ProteomicsNeddylation of Insulin receptor substrate acts as a bona fide suppressor for cancer cell migration
Hyperinsulinemia, often associated with obesity and type 2 diabetes mellitus, is also linked to an elevated risk of various cancers. However, the specific mechanisms underlying this connection remain unclear. Here, we report that inhibiting neddylation, in the presence of insulin treatment, further ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD044760 | Pride
Lc-ms/ms 
ProteomicsLC-MS/MS of MDA-MB468 breast cancer cells grown under normal and glucose deprivation conditions
Mass spectrometry-based spectral count has been a common choice of label-free proteome quantification as its simplicity for the sample preparation and data generation. The discriminatory nature of spectral count in the MS data-dependent acquisition, however, inherently introduces the spectral count ...
ORGANISM(S): Homo sapiens (Human) 
2019-09-25 | PXD013966 | Pride
Breast cancer Lc.ms/ms Label-free 
ProteomicsExpression changes of proteins associated with the development of preeclampsia in maternal plasma: a case control study
Defective deep placentation, an abnormal transformation of the spiral arteries in the junctional zone of the myometrium, is known to cause significant obstetrical complications such as preeclampsia (PE), fetal growth restriction, and placental infarcts with fetal death. Serological biomarkers to pre...
ORGANISM(S): Homo sapiens (Human) 
2018-07-05 | PXD003419 | Pride
Defective deep placentation Mrm Preeclampsia Physiologic transformation of spiral artery Proteomics 
ProteomicsProteomics data reveals Wnt signaling involvement in the hippocampal-dependent behavioral impairment in THRSP-overexpressing ADHD mouse model
Despite the predominance and high heritability of Attention-Deficit/Hyperactivity Disorder (ADHD), its etiology remains elusive. Preclinical and clinical evidence partly points to impaired limbic system function, particularly that of the hippocampus (HPC). Children diagnosed with ADHD often struggle...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-18 | PXD038525 | Pride
Thrsp Mus musculus Lc-ms/ms 
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