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ProteomicsiTRAQ-based analysis of muscle mitochondria isolated from LONP1-mKO mice
This experiment was conducted to identify the mitochondrial protein changes in the presence and absence of LONP1 in skeletal muscle. The following abstract from the submitted manuscript describes the major findings of this work.Disuse-associated loss of muscle LONP1 impairs mitochondrial quality and...
ORGANISM(S): Mus musculus (Mouse) 
2022-01-05 | PXD029722 | Pride
Mouse Skeletal muscle 
MetabolomicsUltraperformance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry-Based Metabolomics and Lipidomics Identify Biomarkers for Efficacy Evaluation of Mesalazine in a Dextran Sulfate Sodium-Induced Ulcerative Colitis Mouse Model
This study aims to identify biomarkers for evaluating the therapeutic efficacy of mesalazine on ulcerative colitis by metabolomics and lipidomics. A dextran sulfate sodium-induced mouse model was used. The disease status was assessed by a disease activity index, the TNF-α level of colon was measured...
2022-10-24 | MTBLS2111 | MetaboLights
ProteomicsSOX4 supports cancer stemness by enhancing HDAC1 transcription revealed by comparative proteomics
We have investigated the proteome changes induced by SOX4 overexpression in HCT-116 cells using iTRAQ-based quantitative proteomics. Bioinformatics analysis revealed that HDAC1 could be one of the important regulators in cancer stem cells (CSCs) maintenance. We found that SOX4 transcriptionally regu...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019694 | Pride
Sox4 Hdac1 Cancer stemness Comparative proteomics 
ProteomicsA proteome-wide effect of PHF8 knockdown in neuronal activity-dependent synaptic plasticity shows downregulation of Parkinson's disease-associated protein Alpha-synuclein and its interactors
Synaptic dysfunction may underlie the pathophysiology of Parkinson’s disease (PD): a presently incurable condition characterized by motor and cognitive symptoms. Here we used quantitative proteomics to study the role of PHF8, a chromatin-modifying enzyme found to be mutated in intellectual disabilit...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-03-10 | PXD036335 | Pride
Synaptic plasticity Neurodegeneracy Proteomics Parkinson's disease Neurodegeneration 
ProteomicsProteomic analysis of S-acylated proteins in human retinal pigment epithelial cells reveals the role of palmitoylation of Niemann–Pick type C1 protein in cholesterol transportation
Palmitoylation is a dynamic process which regulates the activity of the modified proteins. Retinal pigment epithelial (RPE) cells play pivotal roles in visual cycle and maintaining healthy photoreceptor cells. Dysfunctional RPE cells are often associated with degenerative retinal diseases. The aim o...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD034896 | Pride
Niemann-pick type c1 protein Retinal pigment epithelial cells Palmitoylation 
ProteomicsKDM4C epigenetically regulates and forms a feed-forward loop with ALDH1A3 to maintain gastric cancer stemness
Gastric cancer (GC) stem cells (GCSCs) are characterized as high level of ALDH activity, however, the mechanisms of maintenance of high ALDH activity and stemness in GCSCs are largely unknown. Here, we report that KDM4C, a H3K9me2/3-demethylase, epigenetically regulates ALDH1A3 by histone demethylat...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD023455 | Pride
Itraq quantitative proteomics Cancer stem cells Gastric cancer Aldh1a3 Kdm4c 
ProteomicsN-glycoproteome profiling of rice
Metabolic glycan labeling (MGL) is a technique that utilizes bioorthogonal chemical reporters to investigate protein glycosylation. While this method has been widely used for glycoproteomic profiling in animals, its application in N-glycoproteomic research in crops remains limited and requires furth...
ORGANISM(S): Oryza sativa (Rice) 
2025-05-06 | PXD048132 | Pride
Ms/ms Metabolic glycan labeling N-glycosylation Rice 
UnknownIdentification and Characterization of a Novel Di-(2-ethylhexyl) Phthalate Hydrolase from a Marine Bacterial Strain <i>Mycolicibacterium phocaicum</i> RL-HY01.
Not available
S-EPMC12428281 | biostudies-literature
ProteomicsPhospho-proteomics study on FRZB-treated human retinal microvascular endothelial cells (HRECs)
Pathological neovascularization and vascular leakage are central drivers of many sight- threatening diseases. While strategies targeting vascular endothelial growth factor (VEGF) have transformed clinical outcomes, a substantial proportion of patients do not benefit from the treatment, partially att...
ORGANISM(S): Homo sapiens (Human) 
2026-03-13 | PXD073342 | Pride
Frzb Phospho-proteomics Human retinal microvascular endothelial cells 
ProteomicsQuantitative proteomic analysis of vitreous from patients with proliferative diabetic retinopathy (PDR) using SWATH-MS
Pathological neovascularization and vascular leakage are central drivers of many sight- threatening diseases. While strategies targeting vascular endothelial growth factor (VEGF) have transformed clinical outcomes, a substantial proportion of patients do not benefit from the treatment, partially att...
ORGANISM(S): Homo sapiens (Human) 
2026-03-13 | PXD073005 | Pride
Pdr Swath-ms Vitreous proteomics 
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