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TranscriptomicsIn vivo disruption of Rb-E2F-Ezh2 signaling loop causes bladder cancer development
Bladder cancer (BC) is a highly prevalent human disease in which Rb pathway inactivation and epigenetic alterations are common events. However, the connection between these two processes is still poorly understood. Here we show that the in vivo inactivation of all Rb family genes in the mouse urothe...
ORGANISM(S): Homo sapiens 
2014-10-02 | E-GEOD-38264 | biostudies-arrayexpress
GenomicsIdentification of a novel set of DNA methylation markers in bladder cancer using MBD-methylCap/seq and urine DNA screening in a Chinese population
The aim of the present study was to identify novel DNA methylation markers in bladder cancer (BCa) through genome-wide profiling of bladder cancer cell lines and subsequent MSP screening in urine samples. Experimental Design: MBD methylCap/seq was carried out to screen differentially methylated CpG ...
ORGANISM(S): Homo sapiens 
2012-04-30 | E-GEOD-33839 | biostudies-arrayexpress
ProteomicsIdentification of CDK1 phosphorylation of TFCP2L1 from murine embryonic stem cells and bladder cancer cells
Molecular programs involved in embryogenesis are frequently upregulated in oncogenic dedifferentiation and metastasis. However, their precise roles and regulatory mechanisms remain elusive. Here, we showed that CDK1 phosphorylation of TFCP2L1, a pluripotency-associated transcription factor, orches...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2019-11-08 | PXD015635 | Pride
Pluripotency Cdk1 Stemness features Embryonic stem-cell Bladder cancer 
ProteomicsCharacterization of CD44s glycoproteoforms in bladder tumours and bladder cancer cell culture models
Bladder cancer (BC) is a major health concern retaining high mortality rates when diagnosed at advanced stages. In this context, the clinical management of BC requires the introduction of new biomarkers and molecular targets capable to elicit precision medicine therapeutical approaches. A promising ...
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD028307 | Pride
Glycosylation Cd44 Glycoproteogenomics Bladder cancer Alternative splicing 
ProteomicsBiochemical network analysis of protein-protein interactions to monitor the course of T1 bladder cancer patients
Mass spectrometry-based personalized medicine was used to uncover key information in T1-stage bladder cancer (BC) patients and used as a tool to aid clinical decision making. The urinary proteome of patients with recurring versus non-recurring T1-stage BC were compared to uncover information for cli...
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD026784 | Pride
Myeloperoxidase (mpo)  cubilin (cubn). Bladder cancer  urine  proteomics  label-free quantification  mass spectrometry  tumor associated neutrophile Neutrophil extracellular traps 
ProteomicsImmunopeptidome of Renal Cell Carcinoma (RCC) and Bladder Cancer (BC) Patient-Derived Tumor Organoids (PDTOs)
Patient-Derived Tumor Organoids (PDTOs) have emerged as physiologically relevant systems, retaining genomic and phenotypic features of patient tumors and enabling drug response prediction. Here, we established a patient-specific pipeline to evaluate precision immunotherapy in Renal Cell Carcinoma (R...
ORGANISM(S): Homo sapiens (Human) 
2026-08-24 | PXD068567 | Pride
Ligandome Pdtos Mhc Hla-i Dda Immunopeptidomics Hla Immunopeptidome Ligandomics Patient-derived tumor organoids Renal cell carcinoma Rcc Timstof scp Mhc-i Bladder cancer 
ProteomicsComprehensive N-Glycomics Profiling of Urinary Extracellular Vesicles Identifies a Novel Biomarker Panel for Diagnosis of Bladder Cancer
Bladder cancer (BC) is the most common urologic malignancy, facing enormous diagnostic challenges.Urinary extracellular vesicles (EVs) is a particularly promising source for developing diagnostic markers for bladder cancer because of the direct contact between urine and bladder. We investigate bioma...
ORGANISM(S): Homo Sapiens 
2024-11-14 | PXD057882 |
ProteomicsHuman bladder cancer and colon cancer quatitative MS/MS
We analyzed a set of 40 independently collected tumor tissue/control samples using a label-free quantitation single pass LC-MS/MS approach. In this set, 10 samples originated from a colon tumor (i.e. AC) and 10 from control non-malignant tissue samples (NCA), as well as 10 from BC samples and 10 fro...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000082886 | MassIVE
ProteomicsIntegrated Analysis of Global Proteome and Phosphoproteome in Cisplatin Resistant Bladder Cancer Cell Revealed the Molecular Signature Predictive to Patient Survival
Cisplatin-based chemotherapy is the standard care regimen in bladder cancer (BC). However, resistance to the therapy whose molecular mechanisms of the resistance are not fully elucidated rapidly develops in BC patients. Here we introduced multidimensional proteomic analysis providing different level...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD005308 | Pride
Phosphoproteomics Bladder cancer Cisplatin resistance Biological network Molecular signature 
TranscriptomicsRNA-Seq of tissue and plasma extracellular vesicles of breast cancer patients at the time of diagnosis and after the breast surgery
In the current study, we performed deep sequencing analysis of the RNA cargo of plasma EVs collected at the time of diagnosis, during and after the NAC and up to 18 months after the surgery and matched tumor and normal tissues from 35 patients with locally advanced BC, and 30 cancer-free females.
ORGANISM(S): Homo sapiens 
2022-10-24 | E-MTAB-12014 | biostudies-arrayexpress
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