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UnknownThe impact of noise and missing fragmentation cleavages on de novo peptide identification algorithms.
Not available
S-EPMC8956878 | biostudies-literature
ProteomicsMissing proteins identified from the haploid cell lines: HAP1 and KBM-7
Chromosome-centric Human Proteomic Project (C-HPP) aims at identifying and characterizing protein products encoded from all protein-coding genes of human chromosomes. As evident in the recent nature papers, it is possible that those missing proteins may be low abundant in many cell types or expresse...
ORGANISM(S): Homo sapiens (Human) 
2018-10-01 | PXD006614 | Pride
Lc-msms Missing proteins Kbm-7 Haploid cell line Hap1 
ProteomicsEnrichment strategy for searching missing protein
Enrichment strategy for searching missing protein is a project under the guidance of Chromosome-Centric Human Proteome Project (C-HPP). We developed systematical enrichment strategies for revealing the existence of MPs including low molecular weight (LMW), membrane proteins, post-translational modif...
ORGANISM(S): Homo sapiens (Human) 
2015-07-14 | PXD002255 | Pride
Missing protein Chpp Enrichment strategy 
ProteomicsIdentification of missing proteins in the proteome atlas of multiple healthy human tissues
We re-analyzed the deep proteome atlas of 29 paired healthy human from the published paper (Wang, Dongxue, et al. Molecular systems biology 15.2 (2019)) to identify missing proteins.
ORGANISM(S): Homo sapiens (Human) 
2020-11-17 | PXD021391 | Pride
Chpp Open-pfind Missing proteins Mutiple tissues 
ProteomicsMining Missing Membrane Proteins by High-pH Reverse Phase StageTip Fractionation and Validation by Multiple Reaction Monitoring Mass Spectrometry
Several significant efforts have been made in the past decade to map all human proteome. However, more than 3000 proteins are grouped as missing having no evidence of translation. Membrane protein annotation of the current missing proteins list showed 34%to be missing membrane proteins, which are ch...
ORGANISM(S): Homo sapiens (Human) 
2015-07-27 | PXD002224 | Pride
High-ph reverse phase Stagetip Missing proteins Lung cancer 
ProteomicsQuest for missing proteins in the human spermatozoa: an update
Here, we report work as part of C-HPP initiatives on chromosomes 14 (France) and 2 (Switzerland) aiming to identify missing proteins in ejaculated human spermatozoa using multiple MS-based and antibodies-based validation approaches
ORGANISM(S): Homo sapiens (Human) 
2016-07-26 | PXD003947 | Pride
Human Lc-srm Sperm Hpp Fractionation Ihc Missing proteins 
ProteomicsChr18 Consortium MS-data for missing proteins mining
Despite direct or indirect efforts of proteomic community, the fraction of blind spots on the protein map is still significant. Almost 10% (?) of human master protein has no experimental validation up to now. Apparently, proteomics has reached the stage where all easy scores are achieved (?), and ev...
ORGANISM(S): Homo sapiens (Human) 
2020-06-03 | PXD014300 | Pride
Mass-spectrometry Uncertain proteins Missing proteins Chromosome-centric human proteome project (с-hpp) Human proteome Proteotypic peptide Nextprot 
ProteomicsComBat HarmonizR enables the integrated analysis of independently generated proteomic datasets through data harmonization with appropriate handling of missing values
The integration of proteomic datasets, generated by non-cooperating laboratories using different LC-MS/MS setups can overcome limitations in statistically underpowered sample cohorts but has not been demonstrated to this day. In proteomics, differences in sample preservation and preparation strateg...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2022-05-23 | PXD027467 | Pride
Swath Metastudy Missing values Dda Dia Tmt Data integration Ffpe Silac Tissue Harmonisazion Fresh-frozen Combat 
Proteomics2018CHPP - Digging for Missing Proteins Using Low-Molecular-Weight Protein Enrichment and a "Mirror Protease" Strategy
ABSTRACT Since 2012, Chromosome-Centric Human Proteome Project (C-HPP) launched the journey of missing proteins (MPs) investigation for completing human proteome project (HPP). We found the majority of MPs were distributed in low molecular weight (LMW) ranges, especially in 0-40 kDa. The identificat...
ORGANISM(S): Homo sapiens (Human) 
2018-10-04 | PXD010093 | Pride
Testis Low molecular weight Chromosome-centric human proteome project Mirror-protease Missing proteins 
ProteomicsDeep Dive in the Proteome of Human Cerebrospinal Fluid: A Valuable Data Resource for Biomarker Discovery and Missing Protein Identification
Cerebrospinal fluid (CSF) is a body fluid of choice for biomarker studies of brain disorders but remains relatively under-studied compared to other biological fluids such as plasma, partly due to the more invasive means of its sample collection. The present study establishes an in-depth CSF proteome...
ORGANISM(S): Homo sapiens (Human) 
2018-08-29 | PXD009646 | Pride
Augurin  brain  cerebrospinal fluid  human proteome project  mass spectrometry  proteomics  missing proteins  tandem mass tag 
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