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ProteomicsIron response of HepG2 cells - The exon-intron gene structure upstream of the initiation codon predicts translation efficiency
Quantitative proteomics of HepG2 cells in response to iron. SILAC 3plex was conducted
ORGANISM(S): Homo sapiens (Human) 
2018-04-23 | PXD006661 | Pride
Human Lc-ms/ms Hepatocellular cacinoma Iron 
ProteomicsA systematic comparison of label-free, SILAC and TMT techniques to study early adaption towards inhibition of EGFR signaling in the colorectal cancer cell line Difi
The epithelial growth factor receptor (EGFR) signalling network plays an essential role inproliferation and survival of colorectal cancer cells. For this reason, EGFR is targeted using therapeutic antibodies blocking EGFR signalling (e.g. cetuximab). However, anti-EGFR therapy is rarely curative as ...
ORGANISM(S): Homo sapiens (Human) 
2019-12-11 | PXD014565 | Pride
Phosphoproteomics Tmt Anti-egfr therapy Colorectal cancer Silac Mapk Label-free Erbb3 Adaptive mechanism Cetuximab 
ProteomicsProteomic Analysis of Neural Stem Cell to Oligodendrocyte Precursor Cell Differentiation Reveals Phosphorylation-Dependent Dclk1 Processing
The differentiation from neural stem cells (NSCs) to oligodendrocyte precursor cells (OPCs) is only incompletely understood. In the current study, we used the so-called neurosphere assay to study this process. We performed in vitro differentiation from neurospheres (which predominantly consist of NS...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-18 | PXD040652 | Pride
Phosphoproteomics Neural stem cells Dimethyl Tmt Dclk1 Neural development Proximity biotinylation Oligodendrocyte precursor cells Silac Differentiation Isobaric labeling Pura 
ProteomicsEquine muscle-derived mesenchymal stem cells protect cartilage explants in osteoarthritis model: secretome characterization
Background: Osteoarthritis is a highly prevalent joint degenerative disease for which therapeutic treatments are limited or invasive. Cell therapy based on mesenchymal stem/stromal cells (MSCs) is therefore seen as a promising approach for this disease, in both human and horses. Objective: As the r...
ORGANISM(S): Equus caballus (Horse) 
2022-11-08 | PXD031924 | Pride
Stem cells  equine Secretome 
ProteomicsProteome and Secretome Analysis Reveals Differential Post-Transcriptional Regulation of Toll-Like Receptor Responses
Toll-like receptors (TLRs) are essential sensors in innate immunity and among the first to detect invading pathogens. Many studies of TLR responses have focused on the intracellular signaling events that occur upon receptor stimulation. However, proteins released from the cell play a key role in cel...
ORGANISM(S): Mus musculus (Mouse) 
2017-03-06 | PXD004113 | Pride
Macrophage Lc-msms Raw264.7 Mouse Tlr Secretome 3plex silac Targeted ms 
ProteomicsAutophagy Deficiency Promotes Triple-Negative Breast Cancer Resistance to T Cell-Mediated Cytotoxicity by Blocking Tenascin-C Degradation
Most triple-negative breast cancer (TNBC) patients fail to respond to T cell-mediated immunotherapies. Unfortunately, the molecular determinants are still poorly understood. Breast cancer is the disease genetically linked to a deficiency in autophagy. Here, we show that autophagy promotes tumour imm...
ORGANISM(S): Homo sapiens (Human) 
2020-08-05 | PXD019946 | Pride
Tnbc Tenascin-c T cell-mediated killing Autophagy deficiency Immune checkpoint inhibitors 
ProteomicsMulti-omics analyses reveal that HIV-1 alters CD4 T cell immunometabolism to fuel virus replication
Human Immunodeficiency Virus type-1 (HIV-1)-infected individuals show metabolic alterations of CD4 T cells through unclear mechanisms with undefined consequences. We analyzed the transcriptome of CD4 T cells from HIV-1 patients and revealed that elevated oxidative phosphorylation (OXPHOS) pathway i...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD023565 | Pride
Hiv-1 Cd4 t cell Virus replication Nlrx1 Fastkd5 Oxidative phosphorylation 
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