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GenomicsPi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival [ChIPseq]
Background—YAP, the nuclear effector of Hippo signaling, regulates cellular growth and survival in multiple organs, including the heart, by interacting with TEAD sequence specific DNA-binding proteins. Recent studies showed that YAP stimulates cardiomyocyte proliferation and survival. However, the d...
ORGANISM(S): Mus musculus 
2015-02-20 | E-GEOD-57717 | biostudies-arrayexpress
ProteomicsAn Optogenetic-Phosphoproteomic Approach Links Akt Activation to Dynamic Temporal Changes in Signaling in Endothelial Cells
The serine/threonine kinase Akt is a central node in cell signaling. While aberrant Akt activation underlies the development of a variety of human diseases, how different patterns of Akt-dependent phosphorylation dictates downstream signaling and phenotypic outcomes remains largely enigmatic. Herein...
ORGANISM(S): Homo sapiens (Human) 
2023-06-27 | PXD034957 | Pride
Phosphoproteomics Dia-ms Akt Akt1 Mtraq Optogenetics Time course 
ProteomicsThe GATOR2–mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation
Sestrins represent a family of stress-inducible proteins that prevent the progression of many age- and obesity-associated disorders. Endogenous Sestrins maintain insulin-dependent AKT Ser/Thr kinase (AKT) activation during high-fat diet (HFD)-induced obesity, and overexpressed Sestrins activate AKT ...
ORGANISM(S): Homo sapiens (Human) 
2020-01-15 | PXD015824 | Pride
Sestrin2 Akt pkb Liver metabolism Gator2 Mtor 
ProteomicsChemical phosphoproteomics sheds new light on the targets and modes of action of AKT inhibitors
Due to its important roles in oncogenic signaling, AKT has been subject to extensive drug discovery efforts leading to small molecule inhibitors investigated in advanced clinical trials. To better understand how these drugs exert their therapeutic effects at the molecular level, we combined chemopro...
ORGANISM(S): Homo sapiens (Human) 
2021-08-05 | PXD021836 | Pride
Kinobeads Akt inhibitor Phosphoproteomics 
ProteomicsHDX-MS analysis of the mechanism of AKT1 inhibitor binding
Analysis of AKT1 inhibitor binding using HDX-MS .
ORGANISM(S): Homo sapiens (Human) 
2023-02-22 | PXD032929 | Pride
Hdx-ms Akt1 Akt drlink Akt da 
ProteomicsPI3K-AKT pathway and cell-cell contact regulates maspin nuclear localization
Background: Maspin (SERPINB5) is a potential tumor suppressor gene with pleiotropic biological activities, including regulation of cell proliferation, death, adhesion, migration and gene expression. Several studies indicate that nuclear localization is essential for maspin tumor suppression activity...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD023224 | Pride
Cell-to-cell contact Jak-stat Maspin Egfr Pi3k-akt 
ProteomicsAKT but not MYC promotes reactive oxygen species-mediated cell death in oxidative culture
In addition to driving tumorigenesis, oncogenes can create metabolic vulnerabilities in cancer cells. Here, we tested how the oncogenes AKT and MYC affect the ability to shift between respiration and glycolysis. Using immortalized mammary epithelial cellsMCF10A, we discovered constitutively active A...
ORGANISM(S): Homo sapiens (Human) 
2020-03-19 | PXD015122 | Pride
Oxidative culture Proteomics Metabolomics Myc Galactose Catalase Ros Akt Oxidative stress Cancer cells survival; 
UnknownInvolvement of PKA/DARPP-32/PP1α and β- arrestin/Akt/GSK-3β Signaling in Cadmium-Induced DA-D2 Receptor-Mediated Motor Dysfunctions: Protective Role of Quercetin.
Not available
S-EPMC5802731 | biostudies-literature
ProteomicsCombined FGFR and Akt pathway inhibition abrogate growth of EGFR TKI-resistant NSCLC cells with upregulated FGFR1 expression
Introduction: The clinical benefit of EGFR tyrosine kinase inhibitor (TKI) treatment in non-small cell lung cancer (NSCLC) patients with activating EGFR mutations is temporary, as virtually all patients develop acquired EGFR TKI resistance that occurs via diverse mechanisms. Here, we identified incr...
ORGANISM(S): Homo sapiens (Human) 
2021-07-08 | PXD011803 | Pride
Akt inhibitors Shutgun proteomics 4-plex itraq 
UnknownRUNDC3A regulates SNAP25-mediated chemotherapy resistance by binding AKT in gastric neuroendocrine carcinoma (GNEC).
Not available
S-EPMC9233710 | biostudies-literature
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