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ProteomicsProteomic analysis of Nitric Oxide-related Post-translational modifications of PYR/PYL/RCAR receptors of ABA in Arabidopsis thaliana
ABA signaling relies on the perception of the hormone by 14 different members of the PYR/PYL/RCAR family of ABA receptors. Upon ABA binding, receptors become active in inhibiting a family of type 2C protein phosphatases that usually function as negative regulators on protein kinases of the SnRK2 fam...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2015-09-09 | PXD002396 | Pride
Arabidopsis thaliana Lc-msms Whole seedlings Anti-ha immunopurification 
ProteomicsIdentification of deubiquitinases controlled by extracellular matrix stiffness in cancer cells
The project was aimed at identifying deubiquitinases (DUBs) involved in cancer cell mechanosignaling. Lysates from cancer cells grown on collagen matrices with varying stiffnesses were incubated with an activity-based HA-tagged ubiquitin probe that covalently binds DUB active site. To identify DUBs ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-22 | PXD054010 | Pride
Lc-ms/ms Immunopurification Dub abp Ecm stiffness 
ProteomicsMass spectrometry-based characterization of SET1/COMPASS complex in Caenorhabditis elegans
Changes in histone post-translational modifications are associated with aging through poorly defined mechanisms. Histone 3 lysine 4 (H3K4) methylation at promoters is deposited by SET1 family methyltransferases acting within conserved multiprotein complexes known as COMPASS. Using co-immunopurificat...
ORGANISM(S): Caenorhabditis elegans 
2021-12-08 | PXD029904 | Pride
Caenorhabditis elegans Set1/compass complex Interactome Nanolc-ms/ms 
ProteomicsNon-small cell lung cancer-associated Keap1 mutations lead to epigenetic reprogramming and tumorigenesis through CHD6 stabilization
The E3 ubiquitin ligase substrate recognition subunit Keap1 mediates the ubiquitination and degradation of the oxidative stress transcription factor NRF2. Approximately 30% of non-small cell lung cancers (NSCLCs) harbor inactivating mutations in Keap1 or activating mutations in NRF2, both of which l...
ORGANISM(S): Homo sapiens (Human) 
2026-09-11 | PXD060256 | Pride
Non-small lung cancer、chd6、oxidative stress 
ProteomicsSequential Glycosylations at the Multibasic Cleavage Site of SARS-CoV-2 Spike Protein Regulate Viral Activation, Assembly, and Infection
The multibasic furin cleavage site at the S1/S2 boundary of the spike protein (S protein) is a hallmark of SARS-CoV-2 and plays an crucial role in viral infection. O-glycosylation near the furin site catalyzed by host cell glycosyltransferases can theoretically hinder spike protein processing and im...
ORGANISM(S): Homo sapiens (Human) 
2024-03-21 | PXD049110 | Pride
Sars-cov-2 O-glycosylation Galnac-t7 Viral assembly 
ProteomicsSgK269 Interactome - Homo- and Heterotypic Association Regulates Signalling by the SgK269/PEAK1 and SgK223 Pseudokinases
Anti Flag IP of Flag-SgK269 and control IP from MCF10A EcoR cells.
ORGANISM(S): Homo sapiens (Human) 
2016-08-24 | PXD004250 | Pride
Pseudokinase sgk269 Protein-protein interaction 
ProteomicsTagless LysoIP method for molecular profiling of lysosomal content in clinical samples
Lysosomes are implicated in a wide spectrum of human diseases including monogenic lysosomal storage disorders (LSDs), age-associated neurodegeneration and cancer. Profiling lysosomal content using tag-based lysosomal immunopurification (LysoIP) in cell and animal models allowed major discoveries in ...
ORGANISM(S): Homo sapiens (Human) 
2025-01-31 | PXD052082 | Pride
Metabolomics Proteomics Dia Lysosomal storage disorder Lipidomics Lysosome Mass spectrometry 
ProteomicsRACK1 associates with RNA-binding proteins Vigilin and SERBP1 to influence dengue virus replication
Dengue virus (DENV), a re-emerging virus transmitted by Aedes mosquitoes, causes severe pathogenesis in humans. No effective treatment is available against this virus. We recently identified the scaffold protein RACK1 as a component of the DENV replication complex, a macromolecular complex essential...
ORGANISM(S): Homo sapiens (Human) 
2022-02-04 | PXD030765 | Pride
Proteomics Translation optimization Rna stability Rack1 Sirna screen Rna binding protein Cellular factors Vigilin Denv Serbp1 
ProteomicsDengue Virus NS1 Replicon - Dengue virus (DENV) is a major human pathogen that belongs to the flavivirus genus
Dengue virus (DENV) is a major human pathogen that belongs to the flavivirus genus. Among non-structural viral proteins, NS1 is an enigmatic factor that is exclusively encoded by members of the flavivirus genus within the Flaviviridae family and accomplishes different functions during DENV infection...
ORGANISM(S): Homo sapiens (Human) Dengue virus 
2017-11-29 | PXD008120 | Pride
Ns1 Human cells Replicon Dengue virus 
ProteomicsPramel7-Cul2 axis establishes ground-state gene expression in embryonic stem cells
Pluripotency is established in E4.5 preimplantation epiblast, the founder populations of the adult embryo. The establishment of in vitro models that closely resemble ground-state pluripotency represents an important opportunity to study early embryo development. Pramel7, a protein highly expressed i...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-08 | PXD032184 | Pride
Pluripotency Embryonic stem cells Pramel7 Proteasome Cullin 2 
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