Sort   by:  
 Page size 
ProteomicsConsequences of fibroblast ablation in adult murine hearts
Fibroblasts produce the majority of collagen in the heart and are thought to regulate extracellular matrix (ECM) turnover. However, the in vivo role of fibroblasts in structuring the basal ECM network is poorly understood. To examine the effects of fibroblast loss on the microenvironment in the adul...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD021741 | Pride
Shotgun Murine Fibroblast ablated Labelfree analysis 
ProteomicsProteolytic information flows from human knee osteoarthritic cartilage to synovial fluid and defines the roles of key drug targets -1
Objectives: Proteolytic cartilage loss is a major mechanism of osteoarthritis (OA) pathogenesis but few joint breakdown biomarkers are currently available. We sought to determine the overlap of proteolytic peptides in OA cartilage and synovial fluid on a proteome-wide scale with the goals of increa...
ORGANISM(S): Homo sapiens (Human) 
2025-02-04 | PXD048053 | Pride
Proteolysis Synovial fluid Cartilage Protease Proteomics Osteoarthritis 
ProteomicsIdentification of potential protein biomarkers associated with congenital diaphragmatic hernia in human amniotic fluid
Congenital diaphragmatic hernia (CDH) results from incomplete diaphragm development and can be associated with pulmonary hypoplasia, pulmonary hypertension, and heart failure. Currently, few biomarkers are available. Since amniotic fluid comprises proteins of both fetal and maternal origin, its anal...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD041165 | Pride
Surfactant protein b Osteopontin Galectin-3 Amniotic fluid Kallikrein-5 Proteomics 
ProteomicsSubstrate identification of ADAMTS16
Secreted and cell-surface proteases are major mediators of extracellular matrix remodelling, but their mechanisms and regulatory impact are poorly understood. We developed a mass spectrometry approach using cell free ECM produced by mouse Balb/c 3T3 cells in vitro to identify fibronectin as a novel ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2018-04-23 | PXD007284 | Pride
Adamts16 Fibronectin Lc-ms/ms 
ProteomicsPost-translational regulation and proteolytic activity of human adamts-8: a comparison with adamts-1, -4, and -5
A Disintegrin-like And Metalloprotease with Thrombospondin type 1 motifs (ADAMTS)-8 is a secreted protease which has been recently implicated in the pathogenesis of pulmonary arterial hypertension (PAH). However, the substrate repertoire of ADAMTS-8 and regulation of its activity are incompletely u...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027724 | Pride
Ecm Opn Protease Pah Adamts 
ProteomicsDegradomic identification of membrane type 1-matrix metalloproteinase (MT1-MMP/MMP14) as an ADAMTS9 and ADAMTS20 substrate
ADAMTS9 and ADAMTS20 are homologous secreted proteases implicated in ECM proteolysis and ciliogenesis, but few relevant substrates of these proteases are currently known. Quantitative N-terminomics comparison of RPE-1 cells lacking ADAMTS9 with parental RPE-1 cells identified transmembrane protease ...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD036612 | Pride
Mt1-mmp Rpe-1 cells Ciliogenesis Adamts9 Adamts20 Mmp14 Extracellular matrix 
ProteomicsADAMTS7, a target in atherosclerosis, cooperates with homolog ADAMTS12 to protect against myxomatous valve degeneration
The metalloprotease ADAMTS7, a drug target in atherosclerosis and vascular restenosis, is thought to have no relevant physiological role in the cardiovascular system. However, potential cooperation with its close homolog, ADAMTS12, that may mask such a role remains unexplored. The objective of the p...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-05-07 | PXD055550 | Pride
Metalloproteinase Hypertrophy Chondroitin sulfate Heart valve Fibrosis Adamts Regurgitation Extracellular matrix Myxomatous valve 
ProteomicsIdentification of potential protein biomarkers associated with congenital diaphragmatic hernia in human amniotic fluid
Congenital diaphragmatic hernia (CDH) is a severe birth defect frequently associated with pulmonary hypoplasia, pulmonary hypertension, and heart failure. Since amniotic fluid comprises proteins of both fetal and maternal origin, its analysis could provide insights on mechanisms underlying CDH and p...
ORGANISM(S): Homo sapiens (Human) 
2023-11-03 | PXD041859 | Pride
Surfactant protein b Osteopontin Galectin-3 Amniotic fluid Kallikrein-5 Proteomics 
ProteomicsForward and reverse degradomics defines the proteolytic landscape of human knee osteoarthritic cartilage and the role of the serine protease HtrA1
Proteolytic destruction of articular cartilage is a major pathogenic mechanism in osteoarthritis (OA), but was not previously investigated on a proteome-wide scale. We sought to define the human knee OA cartilage degradome.
ORGANISM(S): Homo sapiens (Human) 
2023-11-03 | PXD028060 | Pride
Cartilage Serine protease Osteoarthritis Htra1 
ProteomicsForward and reverse degradomics defines the proteolytic landscape of human knee osteoarthritic cartilage and the role of the serine protease HtrA1
Proteolytic destruction of articular cartilage is a major pathogenic mechanism in osteoarthritis (OA), but was not previously investigated on a proteome-wide scale. We sought to define the human knee OA cartilage degradome and the contribution therein of the serine protease HtrA1, using an N-termino...
ORGANISM(S): Homo sapiens (Human) 
2023-11-03 | PXD028320 | Pride
Degradomics Atoms Osteoarthritis N-terminomics Htra1 
Sort   by:  
 Page size