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ProteomicsMolecular basis of b-adrenergic regulation of cardiac calcium current
Increased cardiac contractility during fight-or-flight response is caused by b-adrenergic augmentation of CaV1.2 channels. It is assumed that this iconic regulation involves phosphorylation of CaV1.2 a1/b-subunits. In transgenic murine hearts expressing fully PKA phosphorylation-deficient mutant a1C...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-19 | PXD014501 | Pride
Isobaric labeling Isoproterenol Tmt Alkaline reversed phase peptide fractionation Non-transgenic Cardiomyocytes Quantitative mass spectrometry Sps ms3 B-adrenergic regulation 
ProteomicsMolecular basis of b-adrenergic regulation of cardiac calcium current
Increased cardiac contractility during fight-or-flight response is caused by b-adrenergic augmentation of CaV1.2 channels. It is assumed that this iconic regulation involves phosphorylation of CaV1.2 a1/b-subunits. In transgenic murine hearts expressing fully PKA phosphorylation-deficient mutant a1C...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-19 | PXD014499 | Pride
Streptavidin Apex Apex2 Alkaline reversed phase peptide fractionation H2o2 Denaturing purification Sps ms3 Cardiac calcium channel B-adrenergic regulation Isobaric labeling Isoproterenol Tmt Proximity labeling Biotin-phenol Quantitative mass spectrometry Cav1.2 Biotin-tyramide On-bead digest Peroxidase catalyzed 
ProteomicsMolecular basis of b-adrenergic regulation of cardiac calcium current
Increased cardiac contractility during fight-or-flight response is caused by b-adrenergic augmentation of CaV1.2 channels. It is assumed that this iconic regulation involves phosphorylation of CaV1.2 a1/b-subunits. In transgenic murine hearts expressing fully PKA phosphorylation-deficient mutant a1C...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-19 | PXD014500 | Pride
Streptavidin Apex Apex2 Alkaline reversed phase peptide fractionation H2o2 Denaturing purification Sps ms3 Cardiac calcium channel B-adrenergic regulation Isobaric labeling Isoproterenol Tmt Proximity labeling Biotin-phenol Quantitative mass spectrometry Cav1.2 Biotin-tyramide On-bead digest Peroxidase catalyzed 
UnknownHeteromerization of chemokine (C-X-C motif) receptor 4 with α1A/B-adrenergic receptors controls α1-adrenergic receptor function.
Not available
S-EPMC4386352 | biostudies-literature
TranscriptomicsGenes regulated by GRK3 in PC3 prostate cancer cells
To identify genes regulated by GRK3 in human cancer cells. Extracted total RNAs from cultured cells, processed samples and hybridized on Illumina Ref8-v3 BeadChips
ORGANISM(S): Homo sapiens 
2013-01-31 | E-GEOD-36022 | biostudies-arrayexpress
TranscriptomicsRemodeling of Brown and White Adipose Tissue by NT-PGC-1α-Mediated Gene Regulation
The β-adrenergic receptor signaling pathway is a major component of adaptive thermogenesis in brown and white adipose tissue during cold acclimation. The β-AR activation highly induces transcriptional coactivator PGC-1α and its splice variant N-terminal (NT)-PGC-1α, promoting the transcription progr...
ORGANISM(S): Mus musculus 
2015-08-07 | E-GEOD-71774 | biostudies-arrayexpress
ProteomicsIntegrated proteomics unveils regulation of cardiac myocytes hypertrophic growth by a nuclear cAMP nanodomain under the control of PDE3A
Signalling by cAMP is organized in multiple distinct subcellular nanodomains regulated by cAMP-hydrolysing phosphodiesterase (PDEs). Cardiac b-adrenergic signalling has served as the prototypical system to elucidate cAMP compartmentalization. Here we employed an integrated interaction and phosphopr...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-03-10 | PXD033773 | Pride
Hypertrophy Sympathetic Phosphodiesterases Adrenegic Camp 
UnknownAllosteric regulation of SERCA by phosphorylation-mediated conformational shift of phospholamban.
Not available
S-EPMC3808617 | biostudies-literature
Unknownβ-Adrenergic regulation of cardiac type 2A protein phosphatase through phosphorylation of regulatory subunit B56δ at S573.
Not available
S-EPMC5823843 | biostudies-literature
ProteomicsTripartite interactions of PKA catalytic subunit and C-terminal domains of cardiac Ca2+ channel may modulate its β-adrenergic regulation
The β-adrenergic augmentation of cardiac contraction, by increasing the conductivity of L-type voltage-gated CaV1.2 channels, is of great physiological and pathophysiological importance. Stimulation of β-adrenergic receptors (βAR) activates protein kinase A (PKA) through separation of regulatory (PK...
ORGANISM(S): Homo sapiens (Human) 
2024-11-22 | PXD057841 | Pride
Calcium channel  protein‐protein interaction  adrenergic regulation  cardiac  protein kinase a (pka)  heterologous expression 
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