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ProteomicsSMALL MOLECULE INHIBITORS OF HNRNPA2B1-RNA INTERACTIONS REVEAL A PREDICTABLE SORTING OF RNA SUBSETS INTO EXTRACELLULAR VESICLES
Extracellular vesicles (EVs) are cell-secreted membranous particles contributing to intercellular communication. Coding and non-coding RNAs are widely detected as EV cargo, and RNAbinding proteins (RBPs), such as hnRNPA2B1, have been circumstantially implicated in EV-RNA sorting mechanisms. However,...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-24 | PXD052658 | Pride
Extracellular vesicles (evs) Paracrine Hnrnpa2b1 Rna High-throughput screening 
ProteomicsOne-shot analysis of translated mammalian lncRNAs with AHARIBO
A vast portion of the mammalian genome is transcribed as long non-coding RNAs (lncRNAs) acting in the cytoplasm with largely unknown functions. Surprisingly, lncRNAs have been shown to interact with ribosomes, encode uncharacterized proteins, or act as ribosome sponges. These functions still remain ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-09-09 | PXD022679 | Pride
Ribosome Proteogenomics Proteomics Ribo-seq Lncrna Rna Translatome Translation 
ProteomicsComparative Proteomic Analysis of Human Vitreous in Rhegmatogenous Retinal Detachment and Diabetic Retinopathy
The vitreous humor can provide important information about physiological and pathophysiological processes within the eye, particularly concerning the retina. Despite the widespread prevalence of various vitreoretinal diseases, that can ultimately lead to blindness, there is not a clear understanding...
ORGANISM(S): Homo sapiens (Human) 
2025-02-24 | PXD050611 | Pride
Diabetic retinopathy Human vitreous humor Rhegmatogenous retinal detachment 
ProteomicsMLL4-associated condensates counterbalance Polycomb-mediated nuclear mechanical stress in Kabuki Syndrome
The genetic elements required to tune gene expression are partitioned in active and repressive nuclear condensates. Chromatin compartments include transcriptional clusters whose dynamic establishment and functioning depends on multivalent interactions occurring among transcription factors, cofactors...
ORGANISM(S): Homo sapiens (Human) 
2020-09-22 | PXD021616 | Pride
Kabuki syndrome Ptm Epiprofile Histone Mass spectrometry 
ProteomicsAstrogliosis and miscommunication in ALS
Chronic activation of glial cells leads to the dysfunction and degeneration of motor and cortical neurons in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) with an unknown mechanism. To shed light on the molecular pathogenetic processes underlying the exordium and contribution...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-29 | PXD064120 | Pride
ProteomicsPolysomal profiling coupled to allele-specific proteomics reveals an EIF4H tranSNP allele possessing higher mRNA translation potential
To search for genetic sources of allele-specific mRNA translation, we leveraged heterozygous polymorphisms and variants present in the exome of HCT116-derived cell lines, computing allelic fractions in total and polysome-associated RNA from RNA-seq data. Allelic imbalance in polysomal RNA led us to ...
ORGANISM(S): Homo Sapiens 
PXD073180 | panorama
ProteomicsRio1 downregulates centromeric RNA levels to promote the timely assembly of structurally fit kinetochores
Kinetochores assemble on centromeres via histone H3 variant CENP-A and low levels of noncoding centromere transcripts (cenRNAs). The latter are ensured by transcription factor Cbf1 (S. cerevisiae), centromere-binding protein CENP-B (humans), and the local histone code downregulating RNA polymerase I...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-07-20 | PXD038337 | Pride
Rat1 Kinetochore Centromere Per centromere Riok1 Rio1 
ProteomicsSINEUP RNA rescues molecular phenotypes associated with CHD8 suppression in Autism Spectrum Disorder model systems
Loss-of-function mutations in the chromodomain helicase DNA-binding 8 (CHD8) gene are strongly associated with Autism Spectrum Disorders (ASD). Indeed, the reduction of CHD8 causes transcriptional, epigenetic and cellular phenotypic changes, correlated to disease that can be monitored in assessing n...
ORGANISM(S): Homo sapiens (Human) 
2025-02-24 | PXD056482 | Pride
Chd8  sineup  autism spectrum disorders (asd)  lncrna  neurodeveloment  zebrafish 
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