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ProteomicsPlasmodium NEK1 coordinates MTOC organisation and kinetochore attachment during rapid mitosis in male gamete formation
Mitosis is an important process in the cell cycle required for cells to divide. Never in mitosis (NIMA)-like kinases (NEKs) are regulators of mitotic functions in diverse organisms. Plasmodium spp, the causative agent of malaria is a divergent unicellular haploid eukaryote with some unusual features...
ORGANISM(S): Plasmodium berghei ANKA 
2024-08-08 | PXD053559 | Pride
Plasmodium Warwick_rtp Nek1 
ProteomicsDivergent Plasmodium kinases drive MTOC, kinetochore and axoneme organisation in male gametogenesis
Sexual development and male gamete formation of the malaria parasite in the mosquito midgut is initiated by rapid endomitosis in the activated male gametocyte. This process is highly regulated by protein phosphorylation, specifically by three divergent male-specific protein kinases (PKs): CDPK4, SRP...
ORGANISM(S): Plasmodium berghei ANKA 
2025-03-18 | PXD061651 | Pride
Plasmodium Warwick_rtp Axoneme Mtoc Gametogenesis Kinetochore Kinase 
ProteomicsReal-time dynamics of Plasmodium Ndc80 reveals unusual modes of chromosome segregation during parasite proliferative stages
Eukaryotic cell proliferation requires chromosome replication and precise segregation to ensure daughter cells have identical genomic copies. The genus Plasmodium, the causative agent of malaria, has developed remarkable characteristic of nuclear division throughout its lifecycle to meet some peculi...
ORGANISM(S): Plasmodium berghei ANKA 
2020-06-09 | PXD017619 | Pride
Ndc80 Chromosome segregation Malaria Parasite Proliferation Warwick-rtp Plasmodium 
ProteomicsProtein Phosphatase 1 regulates atypical chromosome segregation and cell polarity during mitotic and meiotic division in Plasmodium sexual stages
PP1 is a conserved eukaryotic serine/threonine phosphatase that regulates many aspects of mitosis and meiosis, often working in concert with other phosphatases, such as CDC14 and CDC25. The proliferative stages of the parasite life cycle include sexual development within the mosquito vector, with ma...
ORGANISM(S): Plasmodium berghei ANKA 
2021-09-10 | PXD023571 | Pride
Cell division Kinetochore Phosphatase Polarity Sexual stage Warwick-rtp Plasmodium 
ProteomicsMass spectrometry insights into a tandem ubiquitin‐binding domain hybrid engineered for the selective recognition of unanchored polyubiquitin
Unanchored polyubiquitin chains are emerging as important regulators of cellular physiology with diverse roles paralleling those of substrate-conjugated polyubiquitin. However tools able to discriminate unanchored polyubiquitin chains of different isopeptide linkages have not been described. We desc...
ORGANISM(S): Homo sapiens (Human) 
2016-05-18 | PXD004059 | Pride
Ubiquitin Polyubiquitin 
ProteomicsTwo faces of an essential PknB substrate in mycobacteria
Tuberculosis claims nearly 2 million lives annually and its causative agent Mycobacterium tuberculosis is a highly successful pathogen which explores multiple signalling mechanisms to grow and survive in humans for decades. Well-studied protein kinase B (PknB), one of the 11 serine/threonine kinases...
ORGANISM(S): Mycobacterium tuberculosis H37Rv Mycobacterium tuberculosis complex 
2018-09-24 | PXD009239 | Pride
Mycobacterium tuberculosis Pasta domain Cwlm Pknb Murj Peptidoglycan Phosphoproteomics Serine/threonine protein kinase 
ProteomicsPlasmodium ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complex
Mitosis in Plasmodium spp., the causative agent of malaria, is fundamentally different from model eukaryotes, proceeding via a bipartite microtubule organising centre (MTOC) and lacking canonical regulators such as Polo and Bub1 kinases. During schizogony, asynchronous nuclear replication produces a...
ORGANISM(S): Plasmodium berghei ANKA 
2026-01-13 | PXD068821 | Pride
Male gametogony Plasmodium Aurora kinase Cytokinesis Warwick_rtp Spindle Chromosomal passenger complex (cpc) Incenp Karyokinesis Mtoc Transmission 
ProteomicsPlasmodium condensin core subunits (SMC2/SMC4) mediate atypical mitosis and are essential for parasite proliferation and transmission
Condensin is a multi-subunit protein complex regulating chromosome condensation and segregation during cell division. In Plasmodium spp., the causative agent of malaria, cell division is atypical and the role of condensin is unclear. Here we examine the role of SMC2 and SMC4, the core subunits of co...
ORGANISM(S): Plasmodium berghei ANKA 
2020-05-27 | PXD016833 | Pride
Condensin Malaria Parasite Lc-ms Scm2 Warwick-rtp Plasmodium berghei Scm4 
ProteomicsA novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium
Mitosis in eukaryotes involves reorganization of the nuclear envelope (NE) and microtubule-organizing centres (MTOCs). During male gametogenesis in Plasmodium, the causative agent of malaria, mitosis is exceptionally rapid and highly divergent. Within 8 min, the haploid male gametocyte genome underg...
ORGANISM(S): Plasmodium berghei ANKA 
2025-05-19 | PXD062729 | Pride
Warwick_rtp 
ProteomicsMass spectrometry insights into a tandem ubiquitinâ??binding domain hybrid engineered for the selective recognition of unanchored polyubiquitin
Unanchored polyubiquitin chains are emerging as important regulators of cellular physiology with diverse roles paralleling those of substrate-conjugated polyubiquitin. However tools able to discriminate unanchored polyubiquitin chains of different isopeptide linkages have not been described. We desc...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-22 | MSV000079990 | MassIVE
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