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ProteomicsProteomics on post-mortem human brain tissue of patients with Alzheimer`s, Parkinson`s and Lewy body dementias, Brodmann areas (BA) 9, 24 and 40.
We have used HiRIEF (High Resolution Isoelectric Focusing) LC-MS proteomics (Branca et al., 2014, PMID: 24240322) with isobaric tags (TMT10plex) to compare 32 post-mortem human brains in the prefrontal cortex (Brodmann areas 24 and 40) of prospectively followed patients with Alzheimer`s disease (AD)...
ORGANISM(S): Homo sapiens (Human) 
2024-06-10 | PXD047324 | Pride
Human Post-mortem Alzheimer Brain Lewy body dementia Tmt Autopsy Parkinson Brodmann area Hirief Lcms proteomics 
ProteomicsProteomics on post-mortem human brain tissue of patients with Alzheimer`s, Parkinson`s and Lewy body dementias.
We have used HiRIEF (High Resolution Isoelectric Focusing) LC-MS proteomics with isobaric tags (TMT10plex) to compare 32 post-mortem human brains in the prefrontal cortex (Brodmann area 9) of prospectively followed patients with Alzheimer`s disease (AD), Parkinson`s disease with dementia (PDD), deme...
ORGANISM(S): Homo sapiens (Human) 
2017-12-08 | PXD006122 | Pride
Synaptic Lewy body Proteomics Brain Prefrontal cortex Alzheimer Brodmann area 9 Parkinson Hirief Lcms Human 
MetabolomicsStrong effect of Penicillium roqueforti populations on volatile and metabolic compounds responsible for aromas, flavour and texture in blue cheeses
Studies of food microorganism domestication can provide important insight into adaptation mechanisms and lead to commercial applications. Penicillium roqueforti is a fungus with four genetically differentiated populations, two of which were independently domesticated for blue cheese-making, with the...
2021-10-06 | MTBLS1509 | MetaboLights
ProteomicsPurified FLAG-Hrp1 GeLC-MS/MS - CHD1 remodelers regulate nucleosome spacing in vitro and align nucleosomal arrays over gene coding regions in S
Proteomics on affinity purified and mock purified FLAG-Hrp1. Reduction with DTT, alkylation by iodoacetamide. 1D gel, tryptic in gel digestion of cut-out bands, GeLC-MS/MS.
ORGANISM(S): Schizosaccharomyces pombe 
2012-11-01 | PXD000031 | Pride
Gelc Affinity purification Schizosaccharomyces pombe Hrp1 
TranscriptomicsRNA-seq of A431 cell line after gefitinib treatment
RNA sequencing of A431 cell line samples before and after gefitinib treatment, at 0, 2, 6 and 24 hours, was performed in order to characterize the cell line's early and late response to this drug, and to compare against proteomics (mass spectrometry) characterization of the cell line using the same ...
ORGANISM(S): Homo sapiens 
2016-12-01 | E-MTAB-5285 | biostudies-arrayexpress
ProteomicsProteomic screen reveals Fbw7 as a modulator of the NF-kB pathway
Proteomics on HCT116 cells. 3 samples wild-type, 3 samples Fbw7 KO. Subcellular fractionation to cytoplasmic and nuclear fractions. Proteins were reduced with DTT, alkylated with iodoacetamide, digested with trypsin, and labelled with TMT6-plex: 126,127,128 - wildtype; 129,130,131 - Fbw7 KO. Sample...
ORGANISM(S): Homo sapiens (Human) 
2012-06-29 | PXD000005 | Pride
Lc-msms orbitrap human colon epithelium fbw7 hirief 
ProteomicsOOP and PreP peptide cleavage products by LC-MS
Peptide products from individual cleavage assays with the OOP and PreP1 enzymes were acidified by formic acid and injected into LC-MS. 2012oct12 experiment - sample labels (A1, A2, A3, B1, B2, etc...) condition: 1 - OOP 2 - PreP1 3 - ctrl peptide: A - F1beta H-1 4-15 B - F1beta H-2 43-53 C - F1beta...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2013-09-18 | PXD000444 | Pride
Arabidopsis thaliana Prep Lc-ms Peptide cleavage Oop 
UnknownActivation-induced cytidine deaminase-initiated off-target DNA breaks are detected and resolved during S phase.
Not available
S-EPMC3424338 | biostudies-literature
ProteomicsImmunopeptidome analysis of 4T1 murine breast cancer cells.
This study aimed to identify Tumor Associated Antigens (TAA)s by Immunoaffinity purification of MHC peptides and LCMS analysis, verifying their immunogenicity and testing their tumor control potential in a highly aggressive preclinical model of triple-negative breast cancer in mice. Among the MHC pe...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-10 | PXD016112 | Pride
Cancer Ligandome Orbitrap fusion Mouse Murine Immunopeptidome Mhc-i 4t1 
ProteomicsProteomics of U1810 cells upon treatment with microRNAs with an AAGUGC seed motif.
microRNA dysregulation is a common feature of cancer cells, but the complex roles of microRNAs in cancer are not fully elucidated. Here we used functional genomics to identify oncogenic microRNAs in non-small cell lung cancer and to evaluate their impact on response to EGFR targeting therapy. Our da...
ORGANISM(S): Homo sapiens (Human) 
2016-06-28 | PXD004163 | Pride
Human Mirna Lc-ms Microrna U1810 Hirief 
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