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TranscriptomicsGene signature of CLL cells cultured with activated T cells or CD40L-expressing cells
Chronic Lymphocytic Leukemia (CLL) cells multiply in secondary lymphoid tissue but the mechanisms leading to their proliferation are still uncertain. In addition to BCR-triggered signals, other microenvironmental factors might well be involved. In proliferation centres, leukemic B cells are in close...
ORGANISM(S): Homo sapiens 
2013-10-07 | E-GEOD-50572 | biostudies-arrayexpress
TranscriptomicsMajor Patterns of B Cell Gene Expression Changes in Response to Short-Term Stimulation with 33 Single Ligands
We examined the major patterns of changes in gene expression in mouse splenic B cells in response to stimulation with 33 single ligands for 0.5, 1, 2, and 4 h. We found that ligands known to directly induce or costimulate proliferation, namely, anti-IgM (anti-Ig), anti-CD40 (CD40L), LPS, and, to a l...
ORGANISM(S): Mus musculus 
2004-12-08 | E-GEOD-2050 | biostudies-arrayexpress
GenomicsPrimary Human B-cell Temporal Response to CD40L Stimulation
Primary Human B-cell Temporal Response to CD40L Stimulation
PRJNA549251 | ENA
TranscriptomicsPrimary Human B-cell Temporal Response to CD40L Stimulation
RNAseq was used to identify primary human B-cell responses to CD40L stimulation. Primary human peripheral blood B-cells were isolated by negative selection and then subjected to 0, 1 or 18 hours of mega-CD40L stimulation at 50 ng/ml.
ORGANISM(S): Homo sapiens 
2019-07-17 | GSE132835 | GEO
ProteomicsCharacterization of Primary Patient B-cells under Various Stimulation Conditions
The goal of this project was to compare the effects of differential stimulation of primary patient B-cells with CD40L, CpG, anti-IgM, and IL4 individually and in combination. Additionally, we observed a phenomenon where anti-IgM+CpG treatment resulted in a lymphoma-like phenotype and sought to compa...
ORGANISM(S): Homo sapiens (Human) 
2025-08-21 | PXD016961 | Pride
Human Igm B-cells Ms3 Tmt Immunology Cd40l Hbl-1 Sps-ms3 Cpg Il4 11-plex 
TranscriptomicsInduction of interferon-stimulated genes on the IL-4 response axis by Epstein-Barr virus infected human B cells; relevance to cellular transformation.
Epstein-Barr virus (EBV) is an oncogenic virus that is associated with the pathogenesis of several human lymphoid malignancies, including Hodgkin's lymphoma. Infection of normal resting B cells with EBV results in activation to lymphoblasts that are phenotypically similar to those generated by physi...
ORGANISM(S): Homo sapiens 
2014-02-03 | E-GEOD-45829 | biostudies-arrayexpress
UnknownTermination of CD40L co-stimulation promotes human B cell differentiation into antibody-secreting cells.
Not available
S-EPMC9825913 | biostudies-literature
TranscriptomicsMicroarray of MDV infected cultured chicken bursa cells
B lymphocytes from the chicken Bursa of Fabricius were isolated and cultured in the presence of CD40L. Cells were infected with a GFP fluorescent reporter virus of the very virulent Marek's disease virus (vvMDV) strain RB-1B (RB-1B_UL47-GFP, see doi: 10.1073/pnas.1424420112). After 24h viable infect...
ORGANISM(S): Gallus gallus 
2021-07-10 | E-MTAB-10702 | biostudies-arrayexpress
TranscriptomicsImmune Responses to Pneumocystis Infection are Robust in Immunocompetent Mice but Absent in CD40 Ligand Deficient Mice
Pneumocystis is a pathogen of immunocompromised hosts but can also infect healthy hosts, in whom infection is rapidly controlled and cleared. To better understand the immune mechanisms contributing to clearance of infection, microarray methods were used to examine differential gene expression in the...
ORGANISM(S): Mus musculus 
2008-12-22 | E-GEOD-11005 | biostudies-arrayexpress
UnknownHow CD40L reverse signaling regulates axon and dendrite growth.
Not available
S-EPMC7897621 | biostudies-literature
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