Sort   by:  
 Page size 
6-Nitrodopamine Q7 Q8 (6-ND Q9 ) has potent positive chronotropic and inotropic effects. At a very low dose, i.e., 10 fM, it causes potentiation of the positive chronotropic effects induced by catecholamines in the rat atria, indicating a distinct mechanism of action. Cyclase-associated proteins (CA...
ORGANISM(S): Homo sapiens (Human) 
2025-09-08 | PXD066711 | Pride
Lysosomal degradation of the endoplasmic reticulum (ER) via autophagy (ER-phagy) is emerging as a critical regulator of cell homeostasis and function1. The recent identification of ER-phagy receptors has shed light on the molecular mechanism underlining this process; however, the signaling pathways ...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-07-15 | PXD015326 | Pride
The degradation of endoplasmic reticulum (ER) via selective autophagy is driven by the ER-phagy receptors that facilitate the incorporation of ER-fragments into nascent autophagosomes. How these receptors are regulated, in response to ER-phagy-inducing stimuluses, is largely unknown. Here we propose...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2022-10-14 | PXD030451 | Pride
Birt-Hogg-Dubè (BHD) syndrome is an inherited condition caused by loss-of-function mutations in the gene encoding the tumor-suppressor protein folliculin (FLCN) and frequently associated with kidney cysts and cancer. FLCN acts as a negative regulator of TFEB and TFE3 transcription factors, master co...
ORGANISM(S): Homo sapiens (Human) 
2023-04-04 | PXD035450 | Pride
Sort   by:  
 Page size